Retīnskābes ietekme uz TGF-beta2 proteīna sekrēciju un gēna ekspresiju cilvēka un cāļasirds mezenhimālo cilmes šūnu kultūrās.

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Retīnskābes ietekme uz TGF-beta2 proteīna sekrēciju un gēna ekspresiju cilvēka un cāļasirds mezenhimālo cilmes šūnu kultūrās.

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Retīnskābe (RA) ir A vitamīna aktīvā forma, kas regulē vairākus dzīvības procesus embrioģenēzes un arī organisma dzīves laikā. Šī darba mērķis bija salīdzināt retīnskābes iedarbību divu dažādu sugu līdzīga tipa šūnās. Pētījuma gaitā tika noteiktas TGFβ2 proteīna sekrēcijas un gēna ekspresijas izmaiņas trīs cilvēka sirds mezenhimālas cilmes šūnu līnijās un divās cāļu sirds meznehimālas šūnu līnijās, kuras kultivētas barotnēs ar divām dažādām RA koncentrācijām.. TGFβ2 ir citokīns un viens no TGFβ signālceļa ligandiem, kam ir plašs iedarbības spektrs, ieskaitot arī sirds attīstību. Iegūtie dati norāda uz RA dažādo mijiedarbību ar TGFβ2 divu dažādu sugu līdzīga tipa šūnās. Darbs izstrādāts Latvijas Universitātes Bioanalītisko metožu laboratorijā no 2008. gada jūlija līdz 2009. gada maijam.

year	journal	country	edition	language
2009-01-01

https://dspace.lu.lv/dspace/handle/7/22933

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