Tumor Blood Flow and O2 Availability during Hemodilution

1984

An insufficient and heterogeneously distributed nutritive blood flow leads to an inadequate and nonuniform supply of O2 and substrates in many solid tumors (Vaupel, 1977, 1979, 1982). This deterioration of the supply conditions, which already occurs in very early growth stages and which is superimposed by a deterioration of diffusive transport during advanced growth stages, is paralleled by a decrease in the therapeutic efficacy of various cancer treatment modalities such as irradiation and chemotherapy with antiproliferative drugs. In the case of anticancer drugs, the efficiency may be reduced by affecting both pharmacokinetics and pharmacodynamics. In the latter case this is due to the de…

Excavaciones en el Grau Vell

1984

Rural artisans in the Beauce during the nineteenth century

1984

Cálculos perturbativos en modelos de bariones con invariancia quiral

1984

Abnormal Haemostasis and Blood Viscosity in Malignant Hypertension

1984

SummaryWe have previously shown abnormalities of haemostasis suggestive of intravascular coagulation in patients with malignant hypertension, a condition associated with retinopathy and renal fibrin deposition. To determine whether such abnormalities are specific to malignant hypertension, we have measured several haemostatic and haemorheological variables in 18 patients with malignant hypertension (Group 1), 18 matched healthy controls (Group 2), and 18 patients with non-malignant hypertension (Group 3) matched for renal pathology, blood pressure and serum creatinine with Group 1. Both Groups 1 and 3 had increased mean levels of fibrinogen, factor VIIIc, beta-thrombo- globulin, plasma visc…

Zur Kristallchemie der Urate

1984

Neben Hamsaure (UA; eine instabile Modifikation UA-II (1) ist sehr selten), ihrem kationenstabilisierten Dihydrat (UADH (2)) und den sauren Uraten von Natrium und Ammonium werden in Hamsteinen gelegentlich auch Urate von Kalium, Kalzium und Zink gefunden (3). Die allgemeine Formel der Urate lautet Men+ (2-x)/nHxU.aq (Me = Ration der Ladung n; U = Harnsaurerest C5 H2N4 O3 2-; aq = Kristallwasser). Bisher waren nur diskrete Zusammensetzungen mit x = 0,1, 2 bekannt, dJi. keine Mischkristalle. Im physiologischen Harn-pH-Bereich4.8 bis 8 konnen nur die sauren Salze Men+ 1/nHU.aq auftreten (pK1 = 5.47 (4)), bzw. kommt es im sauren Milieu uber weitere Protonierung zur Abscheidung von UADH und schl…

El relleu hispano-romà dels Tossalets (Les Coves de Vinromà)

1984

Se da a conocer un relieve romano procedente de Les Coves de Vinromà (Castellón), sobre cuya interpretación se enuncian diversas hipótesis.

HPLC-Bestimmung von Retinol, Retinal und Retinylestern sowie ihren isomeren Konfigurationen in biologischen Proben

1984

Die HPLC-Bestimmung von Retinol, Retinal, Retinylestern und ihren isomeren Konfigurationen erfolgt mit Hilfe von zwei Detektoren bei verschiedenen Wellenlangen. Der reine Retentionszeiten- und Spektrenvergleich bringt keine hinreichende Genauigkeit.

General Symptomatology of Pathogenic Drug Usage in Old Patients

1984

Drug administration involves the risk of unwanted side effects in patients of any age. This risk is considerably higher in older patients,5 as is shown by several statistics on this subject.8, 16, 18, 21 Higher risk of unwanted side effects in aged subjects is due to the concomitance of a number of factors1,5,17 i. e

Comunicación: Reflexión y Praxis

1984

Se trata del texto de la intervención de José Vidal Beneyto en el "Seminario Internacional de Comunicación y Cultura", organizado por el Instituto Superior de Comunicación y Diseño de Chile, celebrado del 23 al 27 de abril de 1984 en Santiago de Chile. Se incluye el programa del congreso.

Zusammenfassung der Diskussion zum Thema: „Fettsucht und Störungen des Kohlenhydratstoffwechsels“

1984

Die juvenile Adipositas ist heute ein nicht seltener Befund. Kommt diesem Symptom ein Krankheitswert zu, mussen wir bei diesen Patienten mit einem erhohten perioperativen Risiko rechnen?

Profesors Jakovs Beļčikovs: personālais bibliogrāfiskais rādītājs

1984

Saturs: Priekšvārds. Ekonomisko zinātņu doktors profesors Jakovs Beļčikovs / Praude V. Profesora J. Beļčikova publicētie darbi (1965.-1984.) Profesora J. Beļčikova rediģētie un recenzētie darbi. Raksti par profesoru J. Beļčikovu. Profesora J. Beļčikova publicēto darbu alfabētiskais rādītājs. Personu rādītājs.

Primäre oder sekundäre Osteoplastik bei traumatischen Defekten des Unterkiefers

1984

Ausgedehnte Trummer- und Defektfrakturen des Unterkiefers finden sich in unserem grosen traumatologischen Krankengut mit jahrlich etwa 200 Patienten relativ selten. Es erscheint insofern gerechtfertigt, uber unsere Erfahrungen, die wir bei der Versorgung solcher Frakturen machen konnten, zu berichten.

Interrelations between globus pallidus and hippocampal epilepsy in the cat (1)

1984

AbstractElectrically induced afterdischarge (ADs) were evoked in the cats' dorsal hippocampus. The action of the conditioning prestimulation of the pallidus nucleus on AD duration was studied. A significant facilitatory influence was observed when pallidal conditioning stimulation immediately preceded hippocampal test stimulation. The time course of the phenomenon showed a decrease of the conditioning action when the interval between the two stimulations increased: complete disappearance of the effect occurred after about 800 ms. Results are discussed as far as functional relationships between basal ganglia and rhinencephalic system are concerned.

Zur Temperaturabhängigkeit polarographischer Ströme

1984

Zunachst wird ein Uberblick uber die verschiedenen Verfahren zur Bestimmung der Temperaturkoeffizienten polarographischer Strome gegeben. Eine einfache Beziehung wird vorgeschlagen, die in allgemeiner Weise die Bestimmung polarographischer Temperaturkoeffizienten erlaubt. Weiterhin werden die Temperaturkoeffizienten verschiedener polarographischer Strome in 29 Systemen experimentell bestimmt. Die Ergebnisse werden hinsichtlich moglicher Elektrodenreaktionen diskutiert. Der Einflus von Adsorptionsvorgangen auf die Temperaturabhangigkeit polarographischer Strome wird besonders betont.

Perpetual proliferation of LYT-1 cells requires repetitive signals for IL-2 receptor induction by antigen-presenting cells.

1984

Abstract T cell lines with specificity for bovine insulin and ovalbumin were maintained by serial stimulation with antigen presented on irradiated syngeneic spleen cells, alternating 3 days later with subculture in IL-2 containing medium (CM). When the cultures were repetitively split in CM, with concomitant dilution of antigen-presenting cells, a gradual loss of proliferative capacity of the cells in the presence of CM was observed. Absorption studies revealed a 20-fold reduction of IL-2 receptors on the surface of T blasts assayed 12 days after antigenic stimulation as compared with day 5 blasts. This decrement in the number of IL-2 acceptor sites reflected an actual decrease in cell surf…

New developments in CMS in Vicia faba L.

1984

International audience

Effectiveness of Respiratory Hyperoxia, of Normobaric and of Hyperbaric Oxygen Atmospheres in Improving Tumor Oxygenation

1984

A restriction and an inhomogeneous distribution of diffusive and convective oxygen supply is considered the main cause for pronounced radioresistance in solid tumors (Thomlinson and Gray, 1955; Tannock, 1972). One way to alleviate this crucial problem in tumor therapy is the direct enhancement of oxygen delivery to the cancer cells. This can be performed either by the tumor host breathing pure O2 (respiratory hyperoxia, RHO) or by whole body exposure to pure O2 atmospheres at normobaric or hyperbaric pressures (normobaric oxygenation NMO, and hyperbaric oxygenation, HPO, respectively). Numerous investigations have been undertaken both in animals and in man using RHO, NMO, or HPO as an adjuv…

La cisterna del flanco septentrional del foro de Saguntum

1984

Efecto de la agresión quirúrgica sobre las inmunoglobulinas (G.A.M.) y sistema del complemento

1984

An alteration in membrane fluidity can explain the various effects of the herbicides benzoylpropethyl and flampropisopropyl on plant mitochondria

1984

International audience

Ornithophily on the Canary Islands

1984

(1) On the Canary Islands and Madeira typical bird-flowers occur in at least twelve species of six genera, although true flower-birds are absent. This inconsistency is in part elucidated by field observations on exotic and wild plants of Tenerife. —(2) In the Botanical Garden of Orotava it could be observed that various ornithophilous plants, which were introduced there, were visited by indigenous birds for nectar and in one case (Orthostemon) for food tissue. Of the three bird species involved, an endemic race of Chiffchaff (Phylloscopus collybita) and resident Blackcaps (Sylvia atricapilla) exploit, and pollinate, flowers legitimously, while the Wild Canary (Serinus canaria) is predominan…

Cambio rural y burguesía agraria : el señorío de Sueca de la crisis del régimen señorial a la revolución burguesa (1750-1873)

1984

Investigations of Superheavy Quasiatoms via Spectroscopy of δ Rays and Positrons

1984

There exists a long-standing and very interesting problem in atomic physics, namely, the question: What is the binding energy of an electron if the strength of the Coulomb potential exceeds Zα = 1? According to the Dirac-Sommerfeld fine-structure formula for a point charge $$E = {m_e}{c^2}{[1 - {(Z\alpha )^2}]^{1/2}}$$ (1) the total energy of the lowest bound Is-state becomes imaginary for Zα > 1. But even as early as 1945 it was realized(59) that this property of Eq. (1) is caused by the singularity of the Coulomb potential at the origin. Assuming a realistic charge distribution of the nucleus there is no restriction suc as Zα < 1 for the binding energy. Recent calculations show (cf., e.g.…

Functional Analysis of Alloreactive Helper T Cells Involved in the Induction of Cytolytic T Cell Responses In Vitro

1984

When T-responder cells are sensitized in vitro to foreign antigen presented on syngeneic cells or towards allogeneic stimulator cells, a proliferative response is initiated in which antigen specific cytotoxic T lymphocytes (CTL) are generated. The induction of CTL, however, requires the collaboration between functionally distinct T cell subpopulations1–5 and accessory cells from the macrophage lineage, including dendritic cells. The experimental data accumulated so far reveal a cascade of T-T cell interactions and distinct functions of their soluble products resulting in the “Interleukin concept”6 (Fig. 1). Upon receptor-antigen interaction, the “antigen-selected” clones of CTLp become sens…

Trapped Ion Spectroscopy

1984

A single particle, at rest in free space, free of uncontrolled perturbations and at hand for infinitely long times would be the ideal subject for spectroscopic investigations. If the techniques for the preparation of such a particle are available, it becomes feasible to orient the system by a variety of reactions with photons, atoms, and electrons. Line broadening due to Doppler and observation time effects would be minimized.

Electrodermal habituation speed and visual monitoring performance.

1984

Previous research has suggested that speed of habituation of the electrodermal orienting response is related to auditory vigilance performance. The present study investigated the relationship between habituation speed, nonspecific response frequency, and detection performance in a complex visual monitoring task. Two levels of task difficulty were employed. In the visual monitoring task, correct detections declined across blocks, and fewer signals were detected in the difficult task condition. Slow habituators detected more signals than fast habituators, but NSR-frequency was not significantly related to the number of correct detections. The implications of these findings for different model…

Los impresos científicos españoles de los siglos XV y XVI: inventario, bibliometría y thesaurus. Vol. II-III

1984

Los textos científicos impresos son, sin duda alguna, las fuentes de mayor importancia para el estudio de la ciencia moderna. A pesar de ser materiales utilizados reiteradamente desde los primeros estudios históricos, su análisis e incluso su mera localización y descripción continúan siendo insatisfactorios. Estas limitaciones son especialmente evidentes en temas en los que la investigación histórica ha sido escasa. La presente obra intenta contribuir a la superación de las citadas limitaciones en lo que se refiere al caso concreto de la actividad científica desarrollada en la España renacentista. Ofrece, en primer término, un inventario de los correspondientes textos científicos y, en segu…

Evolución demográfica de la Plana Baixa en el siglo XVIII: El caso de Nules

1984

Técnica e Ilustración en Valencia: los proyectos portuarios

1984

Cost of health and water projects and ability of households to pay, in Mali

1984

Gas—liquid chromatographic analyses

1984

Abstract The gas chromatography (GC) of n -alkyl acetates (CH 3 COOR), chloroacetates (CH 2 ClCOOR), dichloroacetates (CHCl 2 COOR) and trichloroacetates (CCl 3 COOR), where the alcohol chain length (R) varied between 1 and 8, and certain of their monochlorinated derivatives, 176 compounds altogether, has been studied on SE-30 and OV-351 glass capillary columns under the same operating conditions. The isomeric monochlorinated esters are eluted in direct order from the 1- chloro to the ω-chloro isomer, the separation of the isomers being complete on OV- 351. On SE-30, however, the peaks of the 6- and 7-chlorooctyl esters are partly overlapped. The separation of the mixtures of odd- and e…

Rapport introductif sur le rôle du rempart dans l’oppidum, structure pré-urbaine.

1984

International audience

Profesors Artūrs Mauriņš: personālais bibliogrāfiskais rādītājs

1984

Saturs: Priekšvārds. Profesors V. Langenfelds. Bioloģijas zinātņu doktors profesors LPSR nopelniem bagātais zinātnes darbinieks Artūrs Mauriņš. Profesora A. Mauriņa publicētie darbi (1948.-1984.) A. Mauriņa rediģētie darbi. Profesora A. Mauriņa vadītās disertācijas. Raksti par profesoru A. Mauriņu. Profesora A. Mauriņa darbu alfabētiskais rādītājs. Personu rādītājs.

Un faux particularisme de la coutume de Nivernais : le droit de blairie

1984

International audience

Génesis y evolución de las forma parakársticas de vallada a partir del estudio sedimentológico de sus rellenos

1984

Se estudia la génesis y episodios evolutivos de un aparato kárstico desarrollado sobre materiales yesíferos en Vallada (Valencia), a partir de su estudio geomorfológico y análisis sedimentológicos. Esto permite diferenciar tres terrazas subterráneas y correlacionarlas con otros depósitos fluviales epigeos (río Cànyoles). Finalmente se establece una interpretación paleoclimática considerando datos polínicos y dos fechaciones radiocarbónicas.