Search results for " Africa"

showing 10 items of 604 documents

Termini Imerese (PA) [Sito 88]

2016

This work will examine the imports of African pottery at Termae Himeraeae, pointing to the atelier of origin and identifying local imitations of African types, according to archaeometrical analyses.

Termini Imerese African pottery archaeometrical analysesSettore L-ANT/09 - Topografia AnticaTermini Imerese ceramica africana analisi archeometricheSettore L-ANT/07 - Archeologia Classica
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Préface de l'ouvrage de Claude Etienne Sissao "Processus d'installation et d'urbanisation en Afrique subsaharienne. Toponymie et gouvernance locale d…

2013

Territorial Intelligence[SHS.ARCHI]Humanities and Social Sciences/Architecture space management[ SHS.ARCHI ] Humanities and Social Sciences/Architecture space managementurbanisationIntelligence Territoriale[SHS.ARCHI] Humanities and Social Sciences/Architecture space managementurbanization sub-Saharan AfricainstallationAfrique subsaharienne
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Paléoenvironnements et caractérisation des roches mères pétrolières des séries pré-salifères du bassin intérieur du Gabon

2003

Resume Le bassin interieur du Gabon, dont l'histoire est liee a la separation des continents Sud-Americain et Africain, comprend des depots continentaux fluvio-lacustres, localement glaciaires, dates du Precambrien superieur a l'Aptien p.p., surmontes par des facies marins aptiens et albiens. L'analyse par pyrolyse Rock–Eval d'echantillons d'affleurements et de forages preleves dans ce bassin met en evidence la presence de facies siliciclastiques riches en matiere organique (jusqu'a 25 % de carbone organique total) de types I et II. Ces niveaux, qui se rencontrent dans le Permien, le Neocomien-Barremien ainsi que dans l'Aptien, constituent d'excellentes roches meres et sont a l'origine des …

Total organic carbonGlobal and Planetary ChangeAptianGeneral Earth and Planetary SciencesCentral africaForestryMesozoicRock evalGeologyComptes Rendus Geoscience
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International solidarity in the GDR and transnationality: an analysis of primary school materials for Namibian child refugees

2014

As part of a solidarity project between the South West African People’s Organization (SWAPO) and the German Democratic Republic (GDR), approximately 430 Namibian children were brought to the GDR from 1979 to 1989 to be trained as an elite for a future liberated Namibia. The children attended school in the GDR until they were brought back to Namibia in August 1990. The school lessons intertwined topics about Namibia and SWAPO with the usual GDR school curriculum. The linchpin of this intertwining was the socialist ideal of international solidarity. This article uses an objective-hermeneutic analysis to show how the school materials produced transnationality.

Transnationalitymedia_common.quotation_subjectRefugeeGender studiesSolidaritylanguage.human_languageDemocracyGermanWest africanPolitical scienceElitelanguageCurriculummedia_commonTransnational Social Review
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S. haematobium as a Common Cause of Genital Morbidity in Girls: A Cross-sectional Study of Children in South Africa

2013

Background Schistosoma (S.) haematobium infection is a common cause of genital morbidity in adult women. Ova in the genital mucosal lining may cause lesions, bleeding, pain, discharge, and the damaged surfaces may pose a risk for HIV. In a heterogeneous schistosomiasis endemic area in South Africa, we sought to investigate if young girls had genital symptoms and if this was associated with urinary S. haematobium. Methodology In a cross-sectional study of 18 randomly chosen primary schools, we included 1057 schoolgirls between the age of 10 and 12 years. We interviewed assenting girls, whose parents had consented to their participation and examined three urines from each of them for schistos…

Travel-Associated Diseasesmedicine.medical_specialtylcsh:Arctic medicine. Tropical medicineInfectious Disease ControlEpidemiologylcsh:RC955-962Cross-sectional studyUrologyGynecologic InfectionsVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Tropical medicine: 761SCHISTOSOMIASIS HAEMATOBIASexually Transmitted DiseasesHelminth InfectionUrineGlobal HealthPediatricsReproductive Tract InfectionsInfectious Disease EpidemiologySchistosomiasis haematobiaSouth AfricaParasitic DiseasesPrevalencemedicineSchistosomiasisAnimalsHumansSex organChildSchistosoma haematobiumSchoolsbiologyGenitourinary Infectionsbusiness.industrylcsh:Public aspects of medicinePublic Health Environmental and Occupational Healthlcsh:RA1-1270biology.organism_classificationSurgeryCross-Sectional StudiesInfectious DiseasesSchistosoma haematobiumNeglected tropical diseasesMedicineWomen's HealthFemalebusinessResearch ArticleNeglected Tropical DiseasesDemographyPLoS Neglected Tropical Diseases
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African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system

2019

Significance Many parasites escape the host immune system by undergoing antigenic variation, a process in which surface antigens are regularly shed and replaced by new ones. Trypanosoma brucei employs multiple sophisticated molecular mechanisms to ensure the expression of a homogeneous VSG coat. We generated a mutant parasite that expresses multiple distinct VSGs and studied the consequences of having a multi-VSG coat during an infection. We showed that expression of multiple VSGs makes the parasites more vulnerable to the immune response, which can now control the trypanosomes from the onset of the infection, allowing most mice to survive. In the future, trypanosome infections may be treat…

Trypanosoma brucei bruceiParasitemiaBiologyTrypanosoma bruceiParasitemiaMicrobiologyHost-Parasite InteractionsMice03 medical and health sciencesImmune systemRAG2HMGB Proteinsparasitic diseasesmedicineAnimalsTrypanosoma brucei030304 developmental biologychemistry.chemical_classification0303 health sciencesMultidisciplinarymonoallelic expressionTDP1030306 microbiologyBiological Sciencesbiology.organism_classificationAcquired immune systemmedicine.diseaseAntigenic VariationVirologyadaptive immune response3. Good healthChromatinTrypanosomiasis AfricanPNAS PluschemistryImmune SystemGlycoproteinTrypanosomiasisVariant Surface Glycoproteins Trypanosomavariant surface glycoproteinProceedings of the National Academy of Sciences
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Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

2019

This paper describes an optimization strategy of the highly active vinyl ketone 3 which was recognized as a strong inhibitor of rhodesain of Trypanosoma brucei rhodesiense, endowed with a ksecond v...

Trypanosoma brucei rhodesienseStrong inhibitorKetoneStereochemistryProtein ConformationPeptide01 natural sciences03 medical and health sciencesStructure-Activity RelationshipSUBSTRATEDrug DiscoverymedicineHumansAfrican trypanosomiasisSulfonesBIOLOGICAL EVALUATION030304 developmental biologyWARHEADchemistry.chemical_classification0303 health sciencesMolecular StructureChemistryDERIVATIVESTrypanosoma brucei rhodesienseCYSTEINE PROTEASES RHODESAIN BIOLOGICAL EVALUATION CATHEPSIN-L INHIBITORS BRUCEI PEPTIDOMIMETICS FALCIPAIN-2 DERIVATIVES SUBSTRATE WARHEADBRUCEImedicine.diseaseFALCIPAIN-2Trypanocidal Agents0104 chemical sciences010404 medicinal & biomolecular chemistryCysteine EndopeptidasesTrypanosomiasis AfricanCYSTEINE PROTEASES RHODESAINCATHEPSIN-LMolecular MedicineINHIBITORSPEPTIDOMIMETICS
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Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.

2020

Starting from the reversible rhodesain inhibitors 1 a-c, which have Ki values towards the target protease in the low-micromolar range, we have designed a series of peptidomimetics, 2 a-g, that contain a benzodiazepine scaffold as a β-turn mimetic; they are characterized by a specific peptide sequence for the inhibition of rhodesain. Considering that irreversible inhibition is strongly desirable in the case of a parasitic target, a vinyl ester moiety acting as Michael-acceptor was introduced as the warhead; this portion was functionalized in order to evaluate the size of corresponding enzyme pocket that could accommodate this substituent. With this investigation, we identified an irreversibl…

Trypanosoma brucei rhodesiensehuman African trypanosomiasiStereochemistryPeptidomimeticmedicine.medical_treatmentSubstituentAntiprotozoal AgentsTrypanosoma bruceiCysteine Proteinase Inhibitors01 natural sciencesBiochemistrychemistry.chemical_compoundBenzodiazepinesStructure-Activity RelationshipDrug DevelopmentParasitic Sensitivity TestsDrug DiscoverymedicineMoietyTrypanosoma bruceiGeneral Pharmacology Toxicology and PharmaceuticsPeptide sequencePharmacologyrhodesainProteasebiologyDose-Response Relationship DrugMolecular Structure010405 organic chemistryOrganic ChemistryTrypanosoma brucei rhodesiensebenzodiazepine scaffoldbiology.organism_classificationpeptidomimetic0104 chemical sciences010404 medicinal & biomolecular chemistryCysteine EndopeptidaseschemistryMolecular MedicinePeptidomimeticsMichael acceptorLead compoundChemMedChem
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Distribution et abondance des mouches piqueuses (Glossinidae, Stomoxys et Tabanidae) dans deux parcs nationaux du Gabon.

2015

11 pages; International audience; In order to minimize risks of pathogen transmission with the development of ecotourism in Gabon, a seasonal inventory has been performed in five contrasted biotopes in Ivindo (INP) and Moukalaba-Doudou (MDNP) National Parks. A total of 10,033 hematophagous flies were captured. The Glossinidae, with six different species identified, was the most abundant group and constitutes about 60% of the captured flies compared to the Stomoxys (6 species also identified) and Tabanidae with 28% and 12%, respectively. The Glossinidae showed a higher rate of capture in primary forest and in research camps. In INP, the Stomoxys showed a higher rate of capture in secondary f…

Tsetse FliesParks RecreationalPopulation DynamicsClimatic seasons[SDV.BID]Life Sciences [q-bio]/BiodiversityForestsDistributionlcsh:Infectious and parasitic diseasesSpecies SpecificityAnimalslcsh:RC109-216GabonEcosystemNational Parks[ SDV.BID ] Life Sciences [q-bio]/Biodiversity[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyHematophagous fliesDipteraMuscidaeHumidityGrasslandGlossinidaeInsect VectorsTrypanosomiasis AfricanVirus DiseasesSeasons[SDE.BE]Environmental Sciences/Biodiversity and EcologyAnimal DistributionResearch Article
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Il teatro romano di Althiburos (El Medeina, El Kef, Tunisia)

2016

Il contributo presenta le attività della missione archeologica dell'Università di Macerata ad Althiburos per lo studio, lo scavo e la valorizzazione del teatro romano della città. Una missione svolta in collaborazione con l'Institut National du Patrimoine de Tunis ed il Politecnico di Bari a partire dal 2006. Le tre campagne di scavo (2007, 2009 e 2010, alle quali va aggiunta una campagna di ricognizione e ricerca di confronti nel 2014, con il cofinanziamento del MAE) hanno permesso di indagare le fasi più recenti della vita dell'edificio e di redigere un primo rilievo del monumento.

Tunisia Althiburos teatro romano architettura romana Africa proconsolareAlthiburoTunisiateatro romanoarchitettura romanaAlthiburosAfrica proconsolare
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