Search results for " Connective tissue disease"
showing 10 items of 848 documents
Successful intravenous immunoglobulin treatment for steroid-resistant eosinophilic enteritis in a patient with systemic lupus erythematosus.
2011
Eosinophilic gastroenteritis is a rare condition of unknown etiology characterized by eosinophilic infiltration of the bowel. Corticosteroids are the mainstay of EG therapy. Although rare, steroid-resistant EG could be a life-threatening condition with tissue destructive evolution. Associations of eosinophilic gastroenteritis with systemic lupus erythematosus have rarely been reported. In this report we describe a case of successful IVIG treatment in a patient with systemic lupus erythematosus and steroid-refractory eosinophilic gastroenteritis. Eosinophilic gastroenteritis is a rare condition of unknown etiology characterized by eosinophilic infiltration of the bowel. Corticosteroids are t…
Skin Erythema Assessment by an RGB Imaging Device: a Clinical Study
2015
In this study, skin erythema assessment of 90 rosacea patients was estimated by a simple, low-cost RGB imaging device. A new erythema index assessment algorithm is proposed and clinically validated. Comparison with dermatologist’s visual assessment shows high correlation.
A bioweapon or a hoax? The link between distinct conspiracy beliefs about the Coronavirus disease (COVID-19) outbreak and pandemic behavior
2020
During the coronavirus disease pandemic rising in 2020, governments and nongovernmental organizations across the globe have taken great efforts to curb the infection rate by promoting or legally prescribing behavior that can reduce the spread of the virus. At the same time, this pandemic has given rise to speculations and conspiracy theories. Conspiracy worldviews have been connected to refusal to trust science, the biomedical model of disease, and legal means of political engagement in previous research. In three studies from the United States ( N = 220; N = 288) and the UK ( N = 298), we went beyond this focus on a general conspiracy worldview and tested the idea that different forms of …
You can���t always get what you want: The role of change goal importance, goal feasibility and momentary experiences for volitional personality devel…
2020
Most adults want to change aspects of their personality. However, previous studies have provided mixed evidence on whether such change goals can be successfully implemented, perhaps partly due to neglecting the goals’ importance and feasibility as well as the experience of trait-relevant situations and states. This study examined associations between change goals and changes in self-reported Big Five traits assessed four times across two years in an age-heterogeneous sample of 382 adults (255 younger adults, Mage = 21.6 years; 127 older adults, Mage = 67.8 years). We assessed trait-relevant momentary situations and states in multiple waves of daily diaries over the first year ( M = 43.9 day…
Age differences in the irrelevant sound effect: A serial recognition paradigm
2015
In adults, the disrupting effect of irrelevant background sounds with distinct temporalspectral variations (changing-state sounds) on short-term memory performance was found to be robust. In the present study, a verbal serial recognition task was used to investigate this so-called Irrelevant Sound Effect (ISE) in adults and 8- to 10-year-old children. An essential part of the short-term memory impairment during changing-state speech is due to interference processes (changing-state effect) which can be differentiated from the deviation effect of auditory distraction. In line with recent findings (Hughes et al., 2013), our study demonstrates that the changing-state effect is not modulated by …
Itch in the era of COVID‐19 pandemic: An unfolding scenario
2020
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious disease, caused by severe acute respiratory syndrome (SARS)‐CoV‐2, that broke out in December 2019. In just 4 months it has spread to almost every country in the world and up to April 18, 2020, the virus has infected more than two million people. Itch is the most common symptom in dermatology and a frequent one of systemic diseases. The association of itch and viral diseases has been widely documented; however, the actual prevalence of itch in the patients suffering from new the SARS‐CoV‐2 infection is still unknown. In this paper, we present a review of the available literature on the topic of itch in the affected population. Mo…
Feasibility of an induced metabolic bioluminescence imaging technique in ovarian cancer: Results of a pilot study.
2016
e17093Background: The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural comple...
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epi…
2015
The development of selective anticancer vaccines that provide enhanced protection against tumor recurrence and metastasis has been the subject of intense research in the scientific community. The tumor-associated glycoprotein MUC1 represents a well-established target for cancer immunotherapy and has been used for the construction of various synthetic vaccine candidates. However, many of these vaccine prototypes suffer from an inherent low immunogenicity and are susceptible to rapid in vivo degradation. To overcome these drawbacks, novel fluorinated MUC1 glycopeptide-BSA/TTox conjugate vaccines have been prepared. Immunization of mice with the 4’F-TF-MUC1-TTox conjugate resulted in strong im…
Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies.
2001
The induction of anti-DNA autoantibodies in systemic lupus erythematosus (SLE) patients is problematic because mammalian DNA is poorly immunogenic at best. Here we demonstrate a chain of connected antibodies in SLE patient sera that could account for the induction of anti-DNA antibody, and possibly for some of the pathogenic features of SLE. We now report that SLE patients, in addition to anti-DNA, produce antibodies to the carboxy-terminal domain of the tumour suppressor molecule p53; this p53 domain recognizes damaged DNA. Hence, these anti-p53 antibodies could mimic damaged DNA immunologically. Indeed, SLE sera do contain anti-idiotypic antibodies to a prototypic anti-p53 antibody. Moreo…
Autoreactivity to mouse C1q in a murine model of SLE.
1995
A large proportion of systemic lupus erythematosus (SLE) patients develop glomerulonephritis, coincident with the appearance of autoantibodies to C1q, the Fc-recognizing collagen-like subcomponent of the first component of complement, C1. The MRL/lpr/lpr mouse is an established model for SLE, developing both antinuclear and anti-type II collagen autoantibodies, and rheumatoid factors(s), exhibiting reduced complement levels and later on developing glomerulonephritis and often arthritis. We report here an age-dependent decrease in serum C1q levels coincident with the development of IgG2b autoantibodies reactive with mouse C1q in MRL/lpr/lpr mice. Unlike IgG2b, although high levels of IgM, Ig…