Search results for " DISORDERS"
showing 10 items of 4492 documents
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
2020
Amyloids are fibrillar protein aggregates associated with diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid polymerization involves three pathological protein transformations; from natively folded conformation to the cross-β conformation, from biophysically soluble to insoluble, and from biologically functional to non-functional. While amyloids share a similar cross-β conformation, the biophysical transformation can either take place spontaneously via a homogeneous nucleation mechanism (HON) or catalytically on an exogenous surface via a heterogeneous nucleation mechanism (HEN). Here, we postulate that…
Project DyAdd : Nonlinguistic theories of dyslexia predict intelligence
2020
Two themes have puzzled the research on developmental and learning disorders for decades. First, some of the risk and protective factors behind developmental challenges are suggested to be shared and some to be specific for a given condition. Second, language-based learning difficulties like dyslexia are suggested to result from or correlate with also nonlinguistic aspects of information processing. In the current study, we investigated how adults with developmental dyslexia and ADHD as well as healthy controls cluster across various dimensions designed to tap the prominent nonlinguistic theories of dyslexia. Participants were 18–55-year-old adults with dyslexia (n = 36), ADHD (n = 22), and…
Mental Health in Athletes: Where Are the Treatment Studies?
2022
In recent years, athletes’ mental health has gained interest among researchers, sport practitioners, and the media. However, the field of sport psychology lacks empirical evidence on the effectiveness of psychotherapeutic interventions for mental health problems and disorders in athletes. Thus far, intervention research in sport psychology has mainly focused on performance enhancement using between-subject designs and healthy athlete samples. In the current paper, we highlight three interrelated key issues in relation to treating mental health problems and disorders in athletes. (i) How are mental health and mental health problems and disorders defined in the sport psychology literature? (i…
Typy i metody psychoterapii osób z zaburzeniami osobowości
2020
Celem niniejszego rozdziału jest omówienie charakterystycznych cech poszczególnych typów zaburzeń osobowości oraz określenie możliwości oddziaływań terapeutycznych w zależności od przyjętego nurtu psychoterapeutycznego. Dysfunkcje w zakresie funkcjonowania osobowości należy rozumieć jako obecność trwałych cech charakterologicznych dla danej osoby i utrwalonych wzorców postępowania, zachowania, relacji z innymi ludźmi i funkcjonowania w społeczności. Dotyczy to również przeżywania siebie i innych oraz stosunku do samego siebie. Powyższe cechy, ze względu na swoją jakość i ilość, utrudniają danej osobie prawidłowe funkcjonowanie społeczne, rodzinne i zawodowe oraz uniemożliwiają lub hamują ro…
SCHIZOFRENIA E ADATTAMENTO NEL CASO DI BEATRICE
2017
This paper is focused on the outcomes of psychotic functioning and, in particular, on individual and contextual elements that could influence the level of adjustment of a patient with schizophrenia. The case of Beatrice, who was diagnosed with schizophrenia at the age of 23, is analyzed using the personal diary that she herself compiled over about fifty years, in which she documented the fundamental events of her life. In the story of B. certain protective factors were highlighted, which enabled B. to have a good quality of life: effective pharmacological therapy with no side-effects, awareness of the pathology, the capacity to build satisfying interpersonal relationships and her religious …
Associations of neuroticism with falls in older adults : do psychological factors mediate the association?
2020
OBJECTIVES Neuroticism predicts falls in older people. In addition, concern about falling and depressive symptoms are associated with fall risk. This study examined whether concern about falling and depressive symptoms mediate the association between neuroticism and falls. METHOD Cross-sectional data on 314 community-dwelling people aged 70–85 years were utilized. Neuroticism was assessed with a short modified form of the Eysenck Personality Inventory. Indoor and outdoor falls during the past year were self-reported. Concern about falling was assessed with the Falls Efficacy Scale-International and depressive symptoms with the Geriatric Depression Scale-15. Path modeling was used to examine…
Longitudinal associations between teacher-child interactions and academic skills in elementary school
2017
This study examined the extent to which the quality of teacher-child interactions assessed in kindergarten (6-year-olds) is associated with children's reading and math development across the elementary school years. The sample consisted of 515 Finnish children (271 boys, 244 girls). Teacher-child interactions were observed in 49 kindergarten classrooms. The findings from the latent growth curve models showed that high-quality teacher–child interactions in kindergarten were positively associated with the initial levels of reading and math skills. Furthermore, the results indicated that high-quality teacher-child interactions in kindergarten were positively associated with children's academic…
Controversies surrounding symptoms and signs of chronic venous disorders
2016
Association of so-called venous symptoms (aching, itching, tingling, burning sensation, swelling, easily fatigued legs, leg heaviness, and leg restlessness) with chronic venous disease (CVD) still remains a controversial issue. Although these symptoms and a decreased quality of life are common in patients with venous incompetence, and are even more frequent in those with a history of venous thrombosis and/or recurrent and bilateral varicose veins, research has actually revealed that these complaints are poorly correlated with objective signs of venous insufficiency. A venous source for these complaints is obvious in patients with advanced CVD, but a substantial part of venous symptoms, espe…
Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experi…
2022
HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir Eliminación del VHC; Trastornos de salud mental; Sofosbuvir/velpatasvir Eliminació del VHC; Trastorns de salut mental; Sofosbuvir/velpatasvir Hepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure in order to achieve HCV elimination. This integrated analysis pooled data from 20 cohorts in seven countries to evaluate the real-world effectiveness of the pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) in people with mental health disorders. HCV-infected patients diagnosed with mental health disorders who were treated with SOF/VEL for 12 w…
Efficacy of “Family Connections”, a program for relatives of people with borderline personality disorder, in the Spanish population: study protocol f…
2020
Abstract Background Patients with borderline personality disorder (BPD) experience significant affect regulation difficulties that cause serious consequences in their work, emotional, and social environments. This dysfunctional pattern also produces great suffering and a heavy burden on their relatives. Fortunately, some studies show that treatment of relatives of people with BPD begins to be important in the patients’ recovery and in improving family dynamics. One of the treatments that has obtained the most empirical support is Family connections (FC). This 12-session program is an adaptation of different Dialectical Behavior Therapy strategies. To test the efficacy of FC, five uncontroll…