Search results for " DOM"
showing 10 items of 2750 documents
Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
2011
For dominantly inherited disorders development of gene therapies, targeting the primary genetic lesion has been impeded by mutational heterogeneity. An example is rhodopsin-linked autosomal dominant retinitis pigmentosa with over 150 mutations in the rhodopsin gene. Validation of a mutation-independent suppression and replacement gene therapy for this disorder has been undertaken. The therapy provides a means of correcting the genetic defect in a mutation-independent manner thereby circumventing the mutational diversity. Separate adeno-associated virus (AAV) vectors were used to deliver an RNA interference (RNAi)-based rhodopsin suppressor and a codon-modified rhodopsin replacement gene res…
Classification of SD-OCT Volumes with LBP: Application to DME Detection
2015
International audience; This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Our method is based on Local Binary Patterns (LBP) features to describe the texture of Optical Coherence Tomography (OCT) images and we compare different LBP features extraction approaches to compute a single signature for the whole OCT volume. Experimental results with two datasets of respectively 32 and 30 OCT volumes show that regardless of using low or high level representations, features derived from LBP texture have highly discriminative power. Moreover, the experimen…
Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling
2015
Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
Initiation of an Aquaculture of Sponges for the Sustainable Production of Bioactive Metabolites in Open Systems: Example, Geodia cydonium.
1999
Among Metazoa, sponges (phylum Porifera) are the richest source for different bioactive compounds. The availability of the raw material is, however, restricted. To obtain enough of the bioactive compounds for application in human therapy, sponges have to be cultured in in vitro systems. One technique for the establishment of a long-term cell culture from sponges has recently been elaborated. Here, we present a procedure to cultivate tissue samples from sponges in an open system. The species Geodia cydonium, which produces bioactive compounds, has been selected. Tissue samples of approximately 10 g were attached to the bottoms of cultivation trays. After 2 to 3 days, the tissue samples forme…
Non-explosive, dome-forming eruptions at Mt. Taranaki, New Zealand
2012
Abstract Volcanic domes may be emplaced rapidly and with few hazardous consequences, even at the summit of large stratovolcanoes. In this study the most recent activity of Mt. Taranaki in New Zealand is shown to have been a passive effusion of a c. 5.9 million m3 lava dome with minor associated explosions and little syn-eruptive hazard. This event, the Sisters eruption, appears to have been unrecorded by local indigenous populations but likely occurred between A.D. 1785 and 1820. The magma erupted is chemically distinct from the preceding A.D. 1755 Tahurangi eruption. Based on breakdown of hornblende crystal rims, the Sisters magma was probably only four days outside the hornblende stabilit…
Resurgent uplift at large calderas and relationship to caldera-forming faults and the magma reservoir: New insights from the Neapolitan Yellow Tuff c…
2021
Abstract Resurgence uplift is the rising of the caldera floor, mainly due to pressure or volume changes in the magma reservoir. Identifying resurgence structures and understanding their relationship to the magmatic reservoir is challenging. We investigate the resurgence structures of the Neapolitan Yellow Tuff caldera (Italy) by integrating bathymetric data, high-resolution seismic profiles and Differential Synthetic-Aperture Radar Interferometry data. Our results show that the resurgent area is manifested as 1) a central dome constituted by two main blocks bounded by NNE-SSW trending faults, 2) an apical graben developed on top of the most uplifted block, 3) a peripheral zone including sev…
The holocene marine record of unrest, volcanism, and hydrothermal activity of campi flegrei and somma-vesuvius
2020
Abstract This chapter illustrates the marine record of a spectrum of volcanic, hydrothermal, and sedimentary features that characterize the Latest Pleistocene–Holocene evolution of the Naples Bay offshore Campi Flegrei and Somma–Vesuvius. The work is based on review of previous literature integrated with interpretation of new high-resolution marine Digital Terrain Models (DTMs) derived from swath bathymetry surveys and high-resolution reflection seismic profiles calibrated with marine gravity core data. Seismic profiles from Pozzuoli Bay provide detailed images of the ring fault system and resurgent dome associated with the evolution of the Neapolitan Yellow Tuff (NYT) collapse caldera and …
Pantelleria island (Strait of Sicily): volcanic history and geomorphological landscape
2017
Pantelleria is a volcanic island located in the Strait of Sicily, 95 km far from the Sicilian coastline and 67 km from Cape Bon (Tunisia). The volcanological history of the island begins approximately 324 ka BP and the last eruptive event was a submarine eruption that occurred on 1891 A.D. Eruptive activity was characterized by seven very intense explosive events, the latest being the Green Tuff (44 ka). They have all produced ignimbrite sheets that covered large sectors of the island. The landscape of the island mirrors the variety of the eruptive styles and their interplay with volcano-tectonics. The most evident geomorphological features are represented by: (i) the mantle-like distributi…
SIGNIFICANCE FOR INTERNATIONAL CORRELATION OF THE PERAPERTÚ FORMATION IN NORTHERN PALENCIA, CANTABRIAN MOUNTAINS. TECTONIC/STRATIGRAPHIC CONTEXT AND …
2021
Small ammonoid assemblages are recorded from the Perapertú Formation in northern Palencia. This is a mudstone unit with local platform limestones characterised by carbonate debris flows on the limestone margins. This unit, of Late Bashkirian to Early Moscovian age, participates in a series of southwards verging thrust slicesNorth of a major fault zone which originated as the head (leading edge) of a large thrust sheet with an internal deformation consisting of thrust slices and at least one nappe structure. Opposed vergencies at the head of this major thrust sheet (Carrionas Thrust Front) and the Ruesga Fault which locally modifies its trace, mark the position where the northern branch of t…
Radošās domāšanas veicināšana, atveidojot portretu guašu krāsas tehnikā vizuālās mākslas stundās 6.klasē
2018
Diplomdarba tēma - Radošās domāšanas veicināšana, atveidojot portretu guašu krāsas tehnikā vizuālās mākslas stundās 6.klasē. Darba mērķis - Izpētīt un analizēt vai iespējams veicināt skolēnos radošo domāšanu, atveidojot portretu guašu krāsas tehnikā. Diplomdarbs sastāv no 4 daļām: Pirmajā daļā diplomdarba autore izpētījusi glezniecības žanru – portrets, vairāk uzzinājusi informāciju par portretu tēlotājmākslā, portreta zīmēšanas secību, krāsu un to īpašības, kā arī krāsu nozīmi psiholoģijā. Otrajā daļā veikts pētījums saistībā ar radošo domāšanu, radoša cilvēka būtību, ko nozīmē radošums, un emociju nozīme. Trešajā daļā apkopota informācija par pētāmās grupas vecumposma īpatnībām. Ceturtajā…