Search results for " Form"

Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures

2017

Glycoprotein research is pivotal for vaccine development and biomarker discovery. Many successful methodologies for reliably increasing the antigenicity toward tumor-associated glycopeptide structures have been reported. Deeper insights into the quality and specificity of the raised polyclonal, humoral reactions are often not addressed, despite the fact that an immunological memory, which produces antibodies with cross-reactivity to epitopes exposed on healthy cells, may cause autoimmune diseases. In the current work, three MUC1 antitumor vaccine candidates conjugated with different immune stimulants are evaluated immunologically. For assessment of the influence of the immune stimulant on a…

Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes.

2002

CD8(+) T cells could make an important contribution to protection against tuberculosis (TB), but the antigenic determinants recognized in the context of major histocompatibility complex class I molecules remain ill defined. Our aim was to identify nonamer peptides derived from the acr/16-kDa antigen. Two immunogenic peptides (p21-29 and p120-128) were identified by their ability to elicit cytotoxic CD8(+) T cells from juvenile patients recovering from TB. Epitope-specific recognition was demonstrated by the lysis of both Mycobacterium tuberculosis-infected and peptide-pulsed macrophages, the release of cytotoxic granules, and interferon-gamma and tumor necrosis factor-alpha production. CD8(…

Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.

1987

Activation of resting T lymphocytes is initiated by the interaction of cell-surface receptors with their corresponding ligands. In addition to activation through the CD3 (T3)-Ti antigen-receptor complex1, recent experiments have demonstrated induction of T-cell proliferation through the CD2 (T11) molecule2–4, traditionally known as the erythrocyte(E)-receptor, through which T cells can bind red blood cells (RBC)5–7. This 'alternative pathway' of T-cell activation2 was observed in vitro in response to combinations of anti-CD2 monoclonal antibodies (mAbs) that bind to distinct epitopes of CD2, such as mAbs against T112 plus T113 (ref. 2). The physiological importance of this activation pathwa…

Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway …

2004

Several reports have stated the ability of gamma delta T cells to inhibit the growth of the asexual blood stages of Plasmodium falciparum in vitro. However, little information is available about the mechanisms involved. In this study, in vitro systems were used to study the role of the granule exocytosis-dependent cytotoxic pathway in the growth inhibition/killing of P. falciparum by human gamma delta T cells. Our results show that the inhibition requires cell-to-cell contact and that gamma delta T cells kill the asexual blood stages of P. falciparum through a granule exocytosis-dependent cytotoxic pathway after recognition of certain ligands or molecules expressed on the surface of infecte…

2. Wittgenstein e l'antropologia. Contro la spiegazione causale e la critica a Frazer

2010

Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease.

2006

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder, characterized by neuronal loss, neurofibrillary tangle formation and the extracellular deposition of amyloid-β (Aβ) plaques. The amyloid precursor protein (APP) and the enzymes responsible for Aβ generation seem to be the base elements triggering the destructive processes. Initially, the low-density lipoprotein receptor-related protein (LRP) was genetically linked to AD and later it emerged to impact on many fundamental events related to this disease. LRP is not only involved in Aβ clearance but is also the major receptor of several AD-associated ligands, e.g. apolipoprotein E and α<sub>2</sub>-m…

Numerical Study of Blow-Up Mechanisms for Davey-Stewartson II Systems

2018

We present a detailed numerical study of various blow-up issues in the context of the focusing Davey-Stewartson II equation. To this end we study Gaussian initial data and perturbations of the lump and the explicit blow-up solution due to Ozawa. Based on the numerical results it is conjectured that the blow-up in all cases is self similar, and that the time dependent scaling is as in the Ozawa solution and not as in the stable blow-up of standard $L^{2}$ critical nonlinear Schr\"odinger equations. The blow-up profile is given by a dynamically rescaled lump.

TANGENTIAL DEFORMATIONS ON FIBRED POISSON MANIFOLDS

2005

In a recent article, Cattaneo, Felder and Tomassini explained how the notion of formality can be used to construct flat Fedosov connections on formal vector bundles on a Poisson manifold $M$ and thus a star product on $M$ through the original Fedosov method for symplectic manifolds. In this paper, we suppose that $M$ is a fibre bundle manifold equipped with a Poisson tensor tangential to the fibers. We show that in this case the construction of Cattaneo-Felder- Tomassini gives tangential (to the fibers) star products.

On the number of solutions of a Duffing equation

1991

The exact number of solutions of a Duffing equation with small forcing term and homogeneous Neumann boundary conditions is given. Several bifurcation diagrams are shown.

Una propuesta práctica para entender, valorar y discernir los enfoques de la enseñanza

2015

La finalidad del artículo es proporcionar una propuesta metodológica para facilitar la comprensión, la valoración y poder discernir los enfoques de la enseñanza propuestos por Fenstermacher y Soltis (1998). En primer lugar se hace referencia a diversas maneras de concebir y clasificar las teorías de enseñanza. En segundo lugar se resaltan los aspectos clave de los enfoques de la enseñanza: los elementos que intervienen en cualquier proceso de enseñanza; la 'manera' de entender la enseñanza; el concepto de persona educada; la compatibilidad o incompatibilidad entre los enfoques; y se ofrece una síntesis de los aspectos más destacados de cada enfoque. En tercer lugar se realiza la propuesta m…