Search results for " Gerontology"

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.

2013

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…

Patients’ preferences for osteoarthritis treatment: the value of stated-preference studies

2019

Context of validation of non-formal and informal learning in Spain: a comprehensive view

2019

The system of validation and accreditation of professional qualifications in Spain is offered as a certification opportunity, especially for vulnerable groups. The procedure is presented as an evaluative proposal that allows some inequalities associated with training and employment to be addressed. In this article we analyse whether this system really fosters social cohesion, considering the political situation that frames the procedure and the educational approach underlying it. The research methodology combines the documentary analysis and interviews with the application of the Delphi method. The most relevant results show that the socio-political context is favourable to competences accr…

The Mediating Role of C-Reactive Protein and Handgrip Strength Between Obesity and Walking Limitation

2008

OBJECTIVES: To study the association between different obesity indicators and walking limitation and to examine the role of C-reactive protein (CRP) and handgrip strength in that association. DESIGN: A cross-sectional, population-based study. SETTING: The Health 2000 Survey with a representative sample of the Finnish population. PARTICIPANTS: Subjects aged 55 and older with complete data on body composition, CRP, handgrip strength, and walking limitation (N=2,208). MEASUREMENTS: Body composition, anthropometrics, CRP, medical conditions, handgrip strength, and maximal walking speed were measured in the health examination. Walking limitation was defined as maximal walking speed less than 1.2…

Impact de la dépendance liée à l’âge sur l’alimentation des personnes âgées

2012

Impact de la dépendance liée à l’âge sur l’alimentation des personnes âgées. 32. journées annuelles de la Société française de gériatrie et gérontologie (SFGG)

"I use it correctly!": The use of ICTs among Italian grandmothers in a generational perspective

2018

In this project, we investigated the role played by digital media and information and communication technologies (ICTs) in building intergenerational and intragenerational relations for grandparents. Specifically, we investigated the possible relationships between grandmothers, children, and grandchildren, with the aim of understanding the dynamics of intergenerational exchanges and how grandmothers experience the use of the Internet as a tool to facilitate communication with family members. The research shows that the reflections regarding the role of the Internet among elderly people are often linked to a generational identity and generational belonging and involve constant comparison wit…

Goût et préférences du consommateur âgé

2017

Revue; Goût et préférences du consommateur âgé. Sixième journée mondiale de la déglutition :

EXTRA VIRGIN OLIVE OIL IMPROVES LEARNING AND MEMORY IN SAMP8 MICE

2011

Abstract. Polyphenols are potent antioxidants found in extra virgin olive oil (EVOO); antioxidants have been shown to reverse age- and disease-related learning and memory deficits. We examined the effects of EVOO on learning and memory in SAMP8 mice, an age-related learning/memory impairment model associated with increased amyloid- protein and brain oxidative damage. We administered EVOO, coconut oil, or butter to 11 month old SAMP8 mice for 6 weeks. Mice were tested in T-maze foot shock avoidance and one-trial novel object recognition with a 24 h delay. Mice which received EVOO had improved acquisition in the T-maze and spent more time with the novel object in one-trial novel object recogni…

Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

2023

Abstract Background Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person’s IC is determined by its domain-specific indicators suggesting a formative measurement model. Aims To develop an IC score applying a formative approach and assess its validity. Methods The study sample (n = 1908) consisted of 57–88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year fu…

Neighborhood Mobility and Unmet Physical Activity Need in Old Age: A 2-Year Follow-Up

2020

Background: Many older people report a willingness to increase outdoor physical activity (PA), but no opportunities for it, a situation termed as unmet PA need. The authors studied whether lower neighborhood mobility and PA precede the development of unmet PA need. Methods: Community-dwelling 75- to 90-year-old people (n = 700) were interviewed annually for 2 years. Unmet PA need, neighborhood mobility, and PA were self-reported. In addition, accelerometer-based step counts were assessed among a subgroup (n = 156). Results: Logistic regression analyses revealed that lower baseline neighborhood mobility (odds ratio 3.02, 95% confidence interval [1.86, 4.90] vs. daily) and PA (odds ratio 4.37…