Search results for " Infection"
showing 10 items of 3396 documents
Determinants of Allergic Sensitization, Asthma and Lung Function: Results from a Cross-Sectional Study in Italian Schoolchildren
2020
Prenatal smoking exposure and early-life respiratory infections are major determinants of asthma during childhood. We investigate the factors influencing allergic sensitization (AS), asthma, and lung function in children and the balance between individual and environmental characteristics at different life stages. 1714 children aged 7&ndash
Prenatal exposure to perfluoroalkyl substances and immune and respiratory outcomes
2018
Prenatal exposure to perfluoroalkyl substances (PFAS) may be associated with impaired immune and respiratory health during childhood but the evidence is scarce and inconsistent. We studied the association between prenatal PFAS exposure and immune and respiratory health up to age 7 years in the Spanish INMA birth cohort (n=1188). We assessed perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorononanoate (PFNA) in maternal plasma samples. Mothers reported the occurrence (yes/no) of chest infections, lower respiratory tract infections, wheezing, asthma, and eczema in the previous 12 months at 1.5 and 4 years of the child and at 7 years. A…
Treatment algorithm for spontaneous spinal infections: A review of the literature
2019
Background: Primary spinal infections are rare pathologies with an estimated incidence of 5% of all osteomyelitis. The diagnosis can be challenging and this might result in a late identification. The etiological diagnosis is the primary concern to determine the most appropriate treatment. The aim of this review article was to identify the importance of a methodological attitude toward accurate and prompt diagnosis using an algorithm to aid on spinal infection management. Methods: A search was done on spinal infection in some databases including PubMed, ISI Web of Knowledge, Google Scholar, Ebsco, Embasco, and Scopus. Results: Literature reveals that on the basis of a clinical suspicion, the…
Spontaneous spinal discitis and spondylodiscitis: Clinicotherapeutic remarks
2017
Spinal infections are rare (their incidence is estimated in about the 5% of all osteomyelitis) and severe pathologies. They are usually identified with different names, as disk space infection, spondylodiscitis, and vertebral osteomyelitis. Spondylodiscitis is the most frequent among spinal infections. The etiology might be due to bacteria, fungi, and parasites and might affect many anatomical structures. The reported incidence is increased in the last years.[1,2] The disease can be classified according to the involved anatomical structure: Vertebral osteomyelitis Discitis and spondylodiscitis Spinal canal infections Adjacent soft tissue infections. In adult patients, the terms osteomyeliti…
Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma.
2021
Survival of patients with oral squamous cell carcinoma (OSCC) is generally low, with the likelihood of locoregional recurrence or disease progression (LR/DP). Knowledge of prognostic factors for survival is key to achieving an understanding and increased survival. The present study aimed to identify prognostic factors for patients with OSCC, especially the presence of DNA from human papillomavirus (HPV). Retrospective cohort study including 119 patients with OSCC treated at the National Cancer Institute in Mexico City (2009-2013). Clinical information was obtained from patient records including LR/DP. Formalin-fixed, paraffin-embedded tissues were obtained and used for detecting DNA from di…
Consistent isotopic differences between Schistocephalus spp. parasites and their stickleback hosts
2015
Published version available at http://dx.doi.org/10.3354/dao02893 Parasite−host systems show markedly variable patterns in isotopic fractionation: parasites can be either depleted or enriched in 15N and 13C as compared to their hosts. However, it remains unknown whether isotopic fractionation patterns are similar in comparable parasite−host systems from markedly different ecosystems. Results of this study show that large-sized Schistocephalus spp. endoparasites are consistently depleted in 15N (by on average −2.13 to −2.20‰) as compared to their nine-spined stickleback Pungitius pungitius and three-spined stickleback Gasterosteus aculeatus hosts. The differences between parasites and host f…
Concurrent staphylococcal and herpes simplex infections – diagnostic pitfalls. A case report
2018
We describe the case of a six-year-old boy with concurrent staphylococcal septicaemia, herpes simplex virus encephalitis (HSVE), and haemorrhagic erosive oesophagitis. Due to guiding clinical and lab symptoms that suggested a diagnosis of staphylococcal sepsis with central nervous system (CNS) involvement, acyclovir treatment was discontinued a"er three days, but the lack of progress in neurological status, further lab tests, and CT and MRI imaging led the authors to consider possible HSV infection, and this diagnosis was con#rmed by PCR test. Even though the treatment for HSV was applied again, the long gap in acyclovir medication contributed to a severe neurological de#cit and an adverse …
Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A tr…
2014
Gram-positive bacteria, in general, and staphylococci, in particular, are the widespread cause of nosocomial and community-acquired infections. The rapid evolvement of strains resistant to antibiotics currently in use is a serious challenge. Novel antimicrobial compounds have to be developed to fight these resistant bacteria, and sortase A, a bacterial cell wall enzyme, is a promising target for novel therapies. As a transpeptidase that covalently attaches various virulence factors to the cell surface, this enzyme plays a crucial role in the ability of bacteria to invade the host's tissues and to escape the immune response. In this study we have screened a small molecule library against rec…
Report of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus isolated in food handlers and surfaces from foodservice establishments.
2012
A set of 53 Staphylococcus aureus isolates collected from food handlers and foodservice establishments in Spain was analyzed for toxic shock syndrome toxin (TSST-1) production. S. aureus strains were isolated from 908 samples collected from different surfaces such as dish towels, workers’ hands, cutting boards, stainless steel tables and slicers, but they were not detected neither in clean plates nor in kitchen knives. Only one food worker hand has been reported to be contaminated by TSST-1 in a restaurant. Despite this, proper hygiene practices should be respected for the surfaces of contact with food, as well as for the hands of the manipulators This is the first article, in Spain, that r…
Photothermal nanofibrillar membrane based on hyaluronic acid and graphene oxide to treat Staphylococcus aureus and Pseudomonas aeruginosa infected wo…
2022
Here we reported the fabrication of an electrospun membrane based on a hyaluronic acid derivative (HA-EDA) to be used as a bandage for the potential treatment of chronic wounds. The membrane, loaded with graphene oxide (GO) and ciprofloxacin, showed photothermal properties and light-triggered drug release when irradiated with a near-infrared (NIR) laser beam. Free amino groups of HA-EDA derivative allowed autocrosslinking of the elec- trospun membrane; thus, a substantial enhancement in the hydrolytic resistance of the patch was obtained. In vitro antibacterial activity studies performed on Staphylococcus aureus and Pseudomonas aeruginosa revealed that such electrospun membranes, due to the…