Search results for " Mal"

showing 10 items of 5318 documents

Testosterone responses to competition: the opponent’s psychological state makes it challenging

2010

Testosterone (T) increases after competition have typically been attributed to winning, yet there is also evidence that being victorious is not in itself sufficient to provoke a T response. Instead, it has been proposed that T responses are moderated by psychological processes. Here, we investigated whether the opponent's psychological state affected hormonal changes in men competing face to face on a rigged computer task. The results show that, irrespective of outcome, the competition led to increases in heart rate and T levels. We found that the T levels of the participants increased more when their opponents had high self-efficacy and that T levels were not influenced by participants' ow…

AdultMaleCompetitive BehaviorAdolescentVALIDATIONDevelopmental psychologyCompetition (economics)OpponentFace-to-faceYoung AdultHORMONAL RESPONSESHeart RateHumansTestosteroneSalivaImportanceAnalysis of VariancePsychological TestsPANAS SCALESCompetitionHUMAN MALESHYPOTHESISGeneral NeuroscienceCORTISOLTestosterone (patch)Challenge hypothesisMENMOTIVATIONAdversaryNEGATIVE AFFECTSelf EfficacyAffectNeuropsychology and Physiological PsychologyMoodMOODChallenge hypothesisPsychologySelf-efficacySocial psychologyStress PsychologicalSocial status
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pBrain: A novel pipeline for Parkinson related brain structure segmentation

2020

[EN] Parkinson is a very prevalent neurodegenerative disease impacting the life of millions of people worldwide. Although its cause remains unknown, its functional and structural analysis is fundamental to advance in the search of a cure or symptomatic treatment. The automatic segmentation of deep brain structures related to Parkinson's disease could be beneficial for the follow up and treatment planning. Unfortunately, there is not broadly available segmentation software to automatically measure Parkinson related structures. In this paper, we present a novel pipeline to segment three deep brain structures related to Parkinson's disease (substantia nigra, subthalamic nucleus and red nucleus…

AdultMaleComputer scienceCognitive NeurosciencePipeline (computing)NeuroimagingSubstantia nigraImage processinglcsh:Computer applications to medicine. Medical informaticslcsh:RC346-429050105 experimental psychologyNeurologia03 medical and health sciences0302 clinical medicineImage Interpretation Computer-Assisted[INFO.INFO-IM]Computer Science [cs]/Medical ImagingImage Processing Computer-AssistedHumans0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingSegmentationlcsh:Neurology. Diseases of the nervous systemAgedStructure (mathematical logic)Artificial neural networkbusiness.industry05 social sciencesBrainReproducibility of ResultsRegular ArticleParkinson DiseasePattern recognitionMiddle AgedMagnetic Resonance ImagingSubthalamic nucleusNeurologyFISICA APLICADAlcsh:R858-859.7Sistema nerviós MalaltiesFemaleNeurology (clinical)Artificial intelligencebusinessError detection and correctionLENGUAJES Y SISTEMAS INFORMATICOS030217 neurology & neurosurgery
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A retrospective radiographic evaluation of the anterior loop of the mental nerve: Comparison between panoramic radiography and cone beam computerized…

2014

Objectives: To compare the prevalence and the length of mental loop, measured with panoramic radiography (PR) and cone beam computerized tomography (CBCT). Material and Methods: PG and CBCT images where analyzed by a single calibrated examiner to determine the presence and the position of the mental foramen (MF), its distance to the lower mandible border, the anterior length of the mental loop (ML) and the bone quality in 82 PR and 82 CBCT. Results: ML was identified in 36.6 % of PR and 48.8 % of CBCT. PR showed a magnification of 1.87 when compared to CBCT. The mean of anterior extension of the inferior alveolar nerve and the distance to the inferior border of the mandible was higher for P…

AdultMaleCone beam computed tomographymedicine.medical_specialtyAdolescentMandibular NerveRadiographyMandibular nerveMagnificationOdontologíaInferior alveolar nerveurologic and male genital diseasesMental foramenYoung Adultstomatognathic systemRadiography PanoramicHumansMedicineGeneral DentistryAgedRetrospective StudiesAged 80 and overbusiness.industryResearchCone-Beam Computed TomographyMiddle Agedrespiratory system:CIENCIAS MÉDICAS [UNESCO]equipment and suppliesCiencias de la saludMental nervemedicine.anatomical_structureOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASFemaleSurgeryTomographyRadiologybusinessNuclear medicineImplantologyMedicina Oral Patología Oral y Cirugia Bucal
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Amelanotic conjunctival melanoma

2006

Conjunctival melanoma is a rare condition of the eye pigment predominantly affecting white adults. We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus. The patient presented with a 2-year history of nonpigmented vascularized nodules of the right eye. Results of hematoxylin and eosin (H and E) staining of the lesion showed an invasive nodule with vertical spreading, invasion of the substantia propria corneae, and ulceration. S100 protein was expressed in the cells of the invasive nodule. HMB45 protein was highly positive in the melanoma cells. The de novo amelanotic mali…

AdultMaleConjunctival melanomaprimary acquired melanosis (PAM).HumansConjunctival NeoplasmsMelanoma AmelanoticConjunctivaImmunohistochemistryamelanotic malignant melanoma
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Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood.

2021

Postzygotic mosaicism (PZM) in NIPBL is a strong source of causality for Cornelia de Lange syndrome (CdLS) that can have major clinical implications. Here, we further delineate the role of somatic mosaicism in CdLS by describing a series of 11 unreported patients with mosaic disease-causing variants in NIPBL and performing a retrospective cohort study from a Spanish CdLS diagnostic center. By reviewing the literature and combining our findings with previously published data, we demonstrate a negative selection against somatic deleterious NIPBL variants in blood. Furthermore, the analysis of all reported cases indicates an unusual high prevalence of mosaicism in CdLS, occurring in 13.1% of p…

AdultMaleCornelia de Lange SyndromeAdolescent Adult Cell Cycle Proteins Child Child Preschool Comparative Genomic Hybridization De Lange Syndrome Female Gene Deletion High-Throughput Nucleotide Sequencing Humans Male Middle Aged Mosaicism Mutation Missense Phenotype Retrospective Studies Spain Young AdultAdolescentSomatic cellScienceGenetic counselingMedizinMutation MissenseDiseasesCell Cycle ProteinsBiologyPaediatric researchGermlineArticle03 medical and health sciencesNegative selectionYoung AdultMedical researchDe Lange SyndromeGenetics researchmedicineMissense mutationHumansClinical significanceChild030304 developmental biologyRetrospective StudiesGenetics0303 health sciencesComparative Genomic HybridizationMultidisciplinaryMosaicismQ030305 genetics & heredityRHigh-Throughput Nucleotide SequencingNIPBLMiddle Agedmedicine.diseasePhenotypeSettore MED/03 - Genetica MedicaSpainChild PreschoolMedicineFemaleGene Deletion
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Staging of osteonecrosis of the jaw requires computed tomography for accurate definition of the extent of bony disease

2014

AbstractManagement of osteonecrosis of the jaw associated with antiresorptive agents is challenging, and outcomes are unpredictable. The severity of disease is the main guide to management, and can help to predict prognosis. Most available staging systems for osteonecrosis, including the widely-used American Association of Oral and Maxillofacial Surgeons (AAOMS) system, classify severity on the basis of clinical and radiographic findings. However, clinical inspection and radiography are limited in their ability to identify the extent of necrotic bone disease compared with computed tomography (CT). We have organised a large multicentre retrospective study (known as MISSION) to investigate th…

AdultMaleCutaneous FistulaSettore MED/50 - Scienze Tecniche Mediche ApplicateDental Fistulastaging system; bisphosphonate; computed tomography; aaoms; osteonecrosis of the jaw; antiresorptive agentsAAOMSAntiresorptive agentSettore MED/29 - Chirurgia MaxillofaccialeAAOMS Antiresorptive agents Bisphosphonate Computed tomography Osteonecrosis of the jaw Staging systemBronj; AAOMS; Antiresorptive agents; Bisphosphonate; Computed tomography; Osteonecrosis of the jaw; Staging systemSettore MED/28 - Malattie OdontostomatologicheMandibular FracturesBronjOsteonecrosis of the jaw; Bisphosphonate; Staging system; AAOMS; Computed tomography; Antiresorptive agentsAlveolar ProcessHumansBisphosphonateMandibular DiseasesComputed tomographyAgedRetrospective StudiesAged 80 and overSuppurationBone Density Conservation AgentsOsteonecrosis of the jawPatient AcuityAntiresorptive agentsCone-Beam Computed TomographyMiddle AgedStaging systemMaxillary DiseasesPhenotypeOtorhinolaryngologyTooth ExtractionBisphosphonate-Associated Osteonecrosis of the JawDrug Therapy CombinationFemaleSurgeryOsteonecrosis of the jaw; Bisphosphonate; Staging system; AAOMS; Computed tomography; Antiresorptive agentsAAOMS; Antiresorptive agents; Bisphosphonate; Computed tomography; Osteonecrosis of the jaw; Staging systemOral SurgeryTomography X-Ray ComputedTomography Spiral ComputedOsteosclerosis
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TESTICULAR SPERM EXTRACTION AND INTRACYTOPLASMIC SPERM INJECTION

1998

We evaluate the efficacy of testicular sperm extraction and results of intracytoplasmic sperm injection in cases of nonobstructive azoospermia. In addition, we define predictive parameters for successful testicular sperm extraction in these patients.A total of 154 patients with nonobstructive azoospermia underwent multiple testicular biopsies to obtain testicular spermatozoa and for histopathological diagnosis. Results of testicular sperm extraction were related to suspected etiology of azoospermia, patient age, maximal testicular volume, serum follicle-stimulating hormone and histopathology. When testicular sperm extraction was successful, intracytoplasmic sperm injection was performed.Spe…

AdultMaleCytoplasmendocrine systemendocrine system diseasesmedia_common.quotation_subjectmedicine.medical_treatmentUrologySemenFertilityFertilization in VitroSuctionTesticleurologic and male genital diseasesIntracytoplasmic sperm injectionInjectionsAndrologyHuman fertilizationPregnancyTestisHumansMedicinereproductive and urinary physiologyOvummedia_commonAzoospermiaurogenital systembusiness.industryOligospermiamedicine.diseaseSpermatozoaTesticular sperm extractionmedicine.anatomical_structureOligospermiaFemalebusinessThe Journal of Urology
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Italian cancer figures, report 2013: Multiple tumours

2013

This collaborative study, based on data collected by the network of Italian association of cancer registries (AIRTUM), provides updated estimates on the incidence risk of multiple primary cancer (MP). The objective is to highlight and quantify the bidirectional associations between different oncological diseases. The quantification of the excess or decreased risk of further cancers in cancer patients, in comparison with the general population, may contribute to understand the aetiology of cancer and to address clinical follow-up.Data herein presented were provided by AIRTUM population-based cancer registries, which cover nowadays 48% of the Italian population. This monograph utilizes the AI…

AdultMaleData Interpretationcancer incidenceAdolescentEpidemiologySettore MED/42 - Igiene Generale E ApplicataNeoplasms Multiple PrimaryCohort StudiesYoung AdultMultiple PrimaryRisk FactorsNeoplasms80 and overHumansChildPreschoolAgedRetrospective StudiesAged 80 and overIncidenceEnvironmental and Occupational Healthmultiple tumourInfantNeoplasms Second Primaryitalian cancer; multiple tumours; cancer incidenceStatisticalMiddle Ageditalian cancerMultiple primary cancer incidenceAdolescent; Adult; Aged; Aged 80 and over; Child; Child Preschool; Cohort Studies; Data Interpretation Statistical; Female; Humans; Incidence; Infant; Italy; Male; Middle Aged; Neoplasms Multiple Primary; Neoplasms Second Primary; Retrospective Studies; Risk Factors; Young AdultSecond PrimaryItalyChild PreschoolData Interpretation StatisticalEpidemiology; Public Health Environmental and Occupational HealthFemalePublic Health
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Surgical Treatment in Symptomatic Chiari Malformation Type I: A Series of 25 Adult Patients Treated with Cerebellar Tonsil Shrinkage

2019

Background: The variety of symptoms and radiological findings in patients with Chiari malformation type I makes both the indication for surgery and the technical modality controversial. We report our 5-year experience, describing our technique and critically evaluating the clinical results. Methods: Between 2012 and 2016, 25 patients (15 female and 10 male; mean age 39.2 years) underwent posterior fossa decompression for Chiari malformation type I. Their clinical complaints included headache, nuchalgia, upper limb weakness or numbness, instability, dizziness and diplopia. Syringomyelia was present in 12 patients (48%). Suboccipital craniectomy was completed in all cases with C1 laminectomy …

AdultMaleDecompressive Craniectomymedicine.medical_specialtyCerebellar Vermi030218 nuclear medicine & medical imaging03 medical and health sciencesChiari malformation type I0302 clinical medicineCHIARI MALFORMATION TYPE IElectrocoagulationmedicineDuraplastyIn patientSurgical treatmentCerebellar tonsil shrinkageAdult patientsSettore MED/27 - Neurochirurgiabusiness.industryLaminectomyDecompression Surgicalmedicine.diseaseMagnetic Resonance ImagingSyringomyeliaArnold-Chiari MalformationSurgeryPosterior fossa decompressionTreatment Outcomemedicine.anatomical_structureRadiological weaponCerebellar tonsilFemalebusiness030217 neurology & neurosurgerySyringomyeliaHuman
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Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis o…

2018

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF…

AdultMaleDiabetes mellituLUNG SAFEOrgan Dysfunction Scoreshumanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Socio-culturaleOrgan Dysfunction ScoreDiabetes ComplicationsDiabetes mellituspuntuaciones de disfunción orgánicaRisk FactorsDiabetes Complicationestudios prospectivosHumansfactores de riesgoProspective StudiesHospital MortalityHypoxiamediana edadAcute hypoxemic respiratory failureAgedRespiratory Distress SyndromeancianoAcute respiratory distress syndromeResearchRespirationrespiraciónRespiratory Distress Syndrome Adultlcsh:Medical emergencies. Critical care. Intensive care. First aidlcsh:RC86-88.9Middle AgedRespiration Artificialinsuficiencia respiratoriaAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFEProspective StudieArtificialAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFE; Aged; Diabetes Complications; Diabetes Mellitus; Female; Hospital Mortality; Humans; Hypoxia; Male; Middle Aged; Organ Dysfunction Scores; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Respiratory Insufficiency; Risk FactorsFemaleRespiratory Insufficiencymortalidad hospitalariacomplicaciones de la diabetesHuman
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