Search results for " Mobilization"
showing 10 items of 58 documents
Plerixafor is effective and safe for stem cell mobilization in heavily pretreated germ cell tumor patients.
2010
Up to 10% of germ cell tumor patients require salvage high-dose chemotherapy with stem cell support, achieving cure rates in the range of 10-60%. Stem cell mobilization may be difficult in these patients because of multiple lines of treatment known to seriously hamper stem cell recovery. Plerixafor significantly enhances the success of the CD34+ cell harvest, even in cases where prior mobilization attempts have failed. Six germ cell tumor patients provided informed consent and were included in the compassionate use program. All patients were heavily pretreated, with a median of 3.5 prior lines of therapy. All failed prior mobilization with G-CSF in combination with chemotherapy. Five patien…
Rituximab in vivo purging is safe and effective in combination with CD34-positive selected autologous stem cell transplantation for salvage therapy i…
2002
The purpose of this study was to evaluate feasibility and efficacy of Rituximab included into a sequential salvage protocol for CD20(+) B-NHL in relapse or induction failure. Twenty-seven patients with CD20(+) B-NHL in relapse or induction failure received Rituximab combined with DexaBEAM (R-DexaBEAM) for stem cell mobilization. Additional ex vivo selection of CD34-positive cells was performed using the CliniMacs device. Two doses of Rituximab were included in the high-dose therapy regimen (HDT). R-DexaBEAM was well tolerated and 26 of 27 patients mobilized sufficient numbers of CD34(+) blood stem cells. Application of R-DexaBEAM resulted in significant depletion of peripheral B cells. No t…
Rituximab combined with DexaBEAM followed by high dose therapy as salvage therapy in patients with relapsed or refractory B-cell lymphoma: mature res…
2014
Summary Salvage therapy followed by high-dose therapy (HDT) remains a mainstay for patients with relapsed lymphoma, however no optimal regimen has been defined. Here we report on the results of R-DexaBEAM (rituximab, dexamethasone, carmustine, etoposide, cytarabine, melphalan) followed by HDT. Patients aged 18–65 years, Eastern Cooperative Oncology Group performance score 0–2, with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) were eligible. R-Dexa-BEAM was given for two cycles followed by stem cell mobilization and HDT. Primary endpoint of the trial was progression-free-survival (PFS). One hundred and three patients were included: aggressive NHL (aNHL): diffuse large B-cell lymphom…
Historicizing Divergence: A Comparative Analysis of the Revolutionary Crises in Russia and Finland
2016
Beginning 1917, Russia and Finland both experienced revolutionary situations, the seizure of power by radical political groups, and civil wars. However, the ultimate outcomes of the revolutionary crises in the two countries turned out to be different: the Russian Bolsheviks won the struggle for power whereas the Finnish Red Guard suffered a defeat. Why did the radical socialists win in Russia but lose in Finland? This chapter argues that the Russian revolutionaries benefited from the existence of two coalition alliances that had not fully materialized in Finland: the workers–soldiers’ alliance, which was critical for the radicals’ seizure of power, and the workers–peasants’ alliance, which …
De las rentas mínimas a la renta básica de las iguales y mucho más
2010
El presente artículo describe la Renta Básica de las Iguales y la contrapone a las rentas mínimas, incluyendo una descripción de la renta garantizada de ciudadanía del País Valencià. La Renta Básica de las Iguales es una herramienta de transformación social vinculada a una intervención social emancipadora The present article describes Citizens' Basic Income, and sets this in contrast to minimum incomes, including a description of the guaranteed citizenship income of the País Valencià. Citizens' Basic Income is a tool for social transformation linked to emancipating social intervention.
Palermo si cura. Pratiche culturali di mutuo soccorso come risposta alle fragilità della città (post)pandemica
2023
In un quadro di riferimento in cui la crisi è globalizzata ma diseguale e in mancanza di un sistema di welfare capace di rispondere alle urgenze dei contesti e dei gruppi sociali più marginalizzati, una risposta ai nuovi bisogni sociali ed individuali è stata offerta da reti solidali e da pratiche di mobilitazione dal basso che svolgono un ruolo di agency territoriale, spesso indipendentemente o in assenza di Istituzioni. Nel contesto palermitano un impegno agito da una pluralità di soggetti culturali già attivi sul territorio, riuniti in un’assemblea pubblica (Palermo si cura), durante il periodo del primo lockdown hanno dato vita ad azioni di mutuo soccorso per rispondere all’emergenza ec…
Movimento femminile e democrazia in Sicilia: la Consulta regionale femminile del 1977
2021
This chapter aims to reconstruct the history of the political mobilization of Italian women. It focuses on the movement that from the early Seventies involved women active in Sicilian women's associations, political parties, and trade unions and, with them, militants who did not belong to any organization. In particular, the essay analyses the role played by the Italian Communist Party in introducing Italian women to the political arena of democratic Italy. In Sicily, one of the results of this mass mobilization and political participation was the political institutionalization into the Sicilian Regional Women's Council, established on 7 May 1977 with regional law number 272. In this contex…
“Mega-Sports Events, Gentrification and Social Mobilization in Rio de Janeiro” - Experiences from Metrô Mangueira
2017
Master's thesis Development management UT503 - University of Agder 2017 In order to promote gentrification of the city of Rio de Janeiro, the Brazilian government and the municipality of Rio de Janeiro have actively used Mega-Sports Events (MSE) in urban planning. Examples are tax cuts and the legalization of various measures for large-scale urban programs, to prepare the city for hosting these prestigious events. Whilst trying to fulfil the obligations from MSEs, the host city denies its citizens access to democratic participation and thereby their right to the city. The promises made to the international sportive federations regarding upgraded infrastructure, sportive arenas, media covera…
An analysis of the activity in the Polish internet sphere from the angle of social mobilization to perform acts of violence. A case study of the immi…
2019
This article is a case study of the process of mobilization to violence on the internet. The goal of this paper was to identify a select number of factors within the narrative on the topic of modern immigration that can be found on the internet and analyze them using the theoretical constructs that can be found in the literature on this subject. The scientists that study genocide have identified several factors commonly found in historically documented events that must be present in order for genocide to occur. In this paper the author will refer to works of scientists such as Helen Fein, Manus I. Midlarsky, Lech M. Nijakowski. The author of the paper analyzed the content published on the i…
A central nervous system-focused treatment approach for people with frozen shoulder: protocol for a randomized clinical trial
2019
Background: Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist. The aim of this study will be to compare the effectiveness of a central nervous system (CNS)-directed treatment program versus a standard medical and physical therapy care program on outcomes in participants with FS. Methods/design: The study is a two-group, randomized clinical trial with blinding of participants and assessors. Participants will be recruited via referrals fr…