Search results for " PROGRESS"

showing 10 items of 1287 documents

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.

2006

Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leukocyte antigen HLA-DR2 or DRB1*1501-DQB1*0602 extended haplotype, confers risk for multiple sclerosis (MS). Previous studies of DRB1 variation and both MS susceptibility and phenotypic expression have lacked statistical power to detect modest genotypic influences, and have demonstrated conflicting results. Results derived from analyses of 1339 MS families indicate DRB1 variation influences MS susceptibility in a complex manner. DRB1*15 was strongly associated in families (P=7.8x10(-31)), and a dominant DRB1*15 dose effect was confirmed (OR=7.5, 95% CI=4.4-13.0, P<0.0001). A modest dose effect…

Models MolecularMaleSequence Homologyimmune system diseasesModelsRisk FactorsDatabases GeneticAdult Alleles Amino Acid Sequence Databases; Genetic Female Genetic Variation Genotype HLA-DR Antigens; chemistry/genetics HLA-DRB1 Chains Humans Male Middle Aged Models; Molecular Molecular Sequence Data Multiple Sclerosis; Chronic Progressive; genetics/immunology Multiple Sclerosis; genetics/immunology Phenotype Risk Factors Sequence Homology; Amino Acidskin and connective tissue diseasesHLA-DRB1Genetics (clinical)GeneticsGeneral MedicineMultiple Sclerosis Chronic ProgressiveMiddle AgedAmino AcidChronic ProgressivePhenotypeFemalemusculoskeletal diseasesAdultMultiple SclerosisGenotypeMolecular Sequence DataLocus (genetics)Human leukocyte antigenBiologyDatabases. Alleles phenotype heterogeneity human leukocyte antigens age of onset chromosomes genes genotype haplotypesmultiple sclerosis relapsing-remitting genetics disability primary progressive multiple sclerosis hla-drb1 gene illness length severity of illnessGeneticGenetic variationGeneticsmedicineHumansAmino Acid SequenceAlleleMolecular BiologyAllelesSequence Homology Amino AcidMultiple sclerosisHaplotypeGenetic VariationMolecularHLA-DR Antigensmedicine.diseasegenetics/immunologychemistry/geneticsImmunologyAge of onsetHLA-DRB1 Chains
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Diversity of Lactobacillus species in deep carious lesions of primary molars

2010

AIM: This was to determine the prevalence of Lactobacilli (LB) species in different stages of caries progression and are considered as secondary invaders of existing carious lesions and specialists for caries progression. METHODS: Carious dentine samples were collected from 70 primary molars (M) during step-wise (S1, S2: n = 35 M) or one-step (O1: n = 35 M) caries treatment and after 11 months of temporary restorations (S3, O2). LB were identified by selected physiological and biochemical characteristics, ratio of lactic acid isomers, electrophoretic mobilities of lactic acid dehydrogenases, and shotgun mass mapping by MALDI mass spectrometry. RESULTS: LB were isolated from 46% of soft dent…

MolarDental CariesBacterial countsDental Pulp CappingMicrobiologyCalcium Hydroxidechemistry.chemical_compoundIsomerismstomatognathic systemHumansMedicineDentistry (miscellaneous)Electrophoretic mobilitiesLactic AcidTooth DeciduousLactobacillus speciesChildCaries treatmentL-Lactate DehydrogenaseLacticaseibacillus rhamnosusbusiness.industryfood and beveragesTemporary restorationMolarBacterial LoadLactic acidDental Restoration TemporaryLactobacillusstomatognathic diseasesCaries excavationchemistrySpectrometry Mass Matrix-Assisted Laser Desorption-IonizationDentinPediatrics Perinatology and Child HealthDisease ProgressionElectrophoresis Polyacrylamide GelDental Cavity PreparationbusinessPulp Capping and Pulpectomy AgentsFollow-Up StudiesEuropean Archives of Paediatric Dentistry
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Algunas notas a Mosquión (fg. 6 N/S) sobre la idea de progreso

2008

Antonio.Melero@uv.es El propósito del presente trabajo es el de pasar revista al fragmento mayor de Mosquión a fin de estudiar su importancia para el estudio del concepto griego de progreso. This paper aims to review, from a stylistic and narrative perspective, Moschion’s main fragment in order to establish his relevance for the study of the Greek concept of progress.

Moschion ; Progress ; Late greek poetry and theatre ; Sophistic:LINGÜÍSTICA [UNESCO]SophisticProgresoSofísticaMosquiónPoesía y teatro griego tardíosProgressMosquión ; Progreso ; Poesía y teatro griego tardíos ; SofísticaLate greek poetry and theatreMoschionUNESCO::LINGÜÍSTICA
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Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.

2014

Given our interest in finding potential antitumor agents and in view of the multifactorial mechanistic nature of cancer, in the present work, taking advantage of the multifunctional ligands approach, new chimeric molecules were designed and synthesized by combining in single chemical entities structural features of SAHA, targeting histone deacetylases (HDACs), with substituted stilbene or terphenyl derivatives previously obtained by us and endowed with antiproliferative and pro-apoptotic activity. The new chimeric derivatives were characterized with respect to their cytotoxic activity and their effects on cell cycle progression on different tumor cell lines, as well as their HDACs inhibitio…

Multifunctional ligandsCell cycle progressionHDAC inhibitionInhibitory postsynaptic potentialBiochemistrySettore BIO/13 - Biologia ApplicataHDACDrug DiscoverymedicineCytotoxic T cellHDAC inhibition; Multifunctional ligands; antiproliferative activity; chimeric compound; stilbeneCancerbiologyChemistryANTIPROLIFERATIVE ACTIVITYOrganic ChemistryMultifunctional ligandsCancermultifunctional ligandmedicine.diseaseCombinatorial chemistrySettore CHIM/08 - Chimica FarmaceuticastilbeneHistoneBiochemistrySTILBENESbiology.proteinchimeric compoundHDAC INHIBITORSEpigeneticsHistone deacetylaseChimeric molecules
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Primary Progressive and progressive relapsing multiple sclerosis show different clinical and instrumental findings and disability progression? A comp…

2013

Multiple Sclerosis Progression Sicilian databaseSettore MED/26 - Neurologia
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Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related d…

2022

Abstract Background Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part. Methods This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000–2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing–remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers’ characteristics, geographic macro-ar…

Multiple SclerosisCenters’ characteristics; Italian Multiple Sclerosis Register; Multiple sclerosis phenotypes; Real-world dataSettore MED/42 - Igiene Generale e ApplicataItalian Multiple Sclerosis RegisterDermatologyGeneral MedicineMultiple Sclerosis Chronic ProgressiveSettore MED/26Settore SECS-S/04 - DemografiaCenters’ characteristicsMultiple sclerosis phenotypeReal-world dataSettore MED/01 - Statistica MedicaPsychiatry and Mental healthMultiple Sclerosis Relapsing-RemittingPhenotypeRecurrenceHumansFemaleSettore MED/26 - NeurologiaNeurology (clinical)Centers’ characteristicReferral and ConsultationMultiple sclerosis phenotypes
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Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register.

2022

Background: Definitions for reliable identification of transition from relapsing-remitting multiple sclerosis (MS) to secondary progressive (SP)MS in clinical cohorts are not available. Objectives: To compare diagnostic performances of two different data-driven SPMS definitions. Methods: Data-driven SPMS definitions based on a version of Lorscheider’s algorithm (DDA) and on the EXPAND trial inclusion criteria were compared, using the neurologist’s definition (ND) as gold standard, in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Akaike information criterion (AIC) and area under the curve (AUC). Results: A cohort of 10,240 MS patients wi…

Multiple SclerosisMultiple Sclerosis Chronic ProgressiveMultiple sclerosisMultiple Sclerosis Relapsing-RemittingNeurologybig dataArea Under Curvedata-driven algorithmdisease registrysecondary progressiveHumansSettore MED/26 - NeurologiaNeurology (clinical)prognosisMultiple sclerosis (Houndmills, Basingstoke, England)
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Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

2020

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit an…

Multiple Sclerosismedicine.drug_classLymphocyte depletionrelapsing–remittingMonoclonal antibodyPrimary progressive03 medical and health sciences0302 clinical medicineMultiple Sclerosis Relapsing-Remittingreal lifemedicineHumansImmunologic Factors030212 general & internal medicineSecondary progressiveRetrospective Studiesprimary progressivebusiness.industryMultiple sclerosisRituximab; multiple sclerosis; primary progressive; real life; relapsing–remitting; secondary progressiveTreatment optionsmedicine.diseaseNeurologyRelapsing remittingItalymultiple sclerosiImmunologysecondary progressiveRituximabSettore MED/26 - NeurologiaNeurology (clinical)businessRituximab030217 neurology & neurosurgerySwitzerlandmedicine.drug
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Progression is independent of relapse activity in early multiple sclerosis: a real-life cohort study

2022

Portaccio et al. report that in early relapsing-onset multiple sclerosis, progression independent of relapse activity is an important contributor to disability accumulation. Insidious progression occurs even in the earliest disease phases, suggesting that inflammation and degeneration may represent a single disease continuum.Disability accrual in multiple sclerosis may occur as relapse-associated worsening or progression independent of relapse activity. The role of progression independent of relapse activity in early multiple sclerosis is yet to be established. The objective of this multicentre, observational, retrospective cohort study was to investigate the contribution of relapse-associa…

Multiple Sclerosisrelapse-associated worseningprogression independent of relapse activityrelapsing multiple sclerosisCohort StudiesMultiple Sclerosis Relapsing-Remittingrelapse associated worseningRecurrenceChronic DiseaseDisease ProgressionHumansSettore MED/26 - NeurologiaNeurology (clinical)Retrospective Studies
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L'ornementation des bracelets de l'âge du Bronze européen : analyse descriptive et perspectives

2013

This paper discusses the ornamental patterns of metal bracelets worn on the arms and legs of people during the European Bronze Age. A method has been specially created to study geometric patterns. Some sets of metal bands (bracelets métalliques) of Bronze Age reach a high level of complexity due to the use of combined patterns in an overall structure. This paper deals with an experimental criterion concerning this phenomenon. The methodology, developed for the purpose i.e. the experimental criterion developed for the purpose of this study, was to extract geometric patterns from the original media. The principle is to release the geometrical compositions of the deformations induced by the mo…

Méditerranée[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistorytextiledérivation stylistiqueChasséendécor géométriqueméthodes régressive et progressiveparure et surfaces vestimentairesChalcolithiqueâge du Bronzeracine cognitive[ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and PrehistoryMiddle Bronze Agemetal productioncopies and imitationsbraceletsgeometric morphometricsserial production
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