Search results for " SLE"

showing 10 items of 597 documents

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

2013

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I IFN pathway. In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which have been shown to alter the protein function influencing systemic lupus erythematosus (SLE) susceptibility, are involved in SSc susceptibility and clinical phenotypes. For that purpose, we genotyped one representative single-nucleotide polymorphism (SNP) of each block (rs10488631, r…

MaleLinkage disequilibrium:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]Polimorfismo de nucleótido simpleSLElcsh:MedicineAutoimmunityGenome-wide association studyLinkage DisequilibriumScleroderma:Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Gene Frequency:Named Groups::Persons::Population Groups::Continental Population Groups::European Continental Ancestry Group [Medical Subject Headings]Risk FactorsIRF5Genetics of the Immune SystemLupus Erythematosus Systemic:Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Scleroderma Systemic [Medical Subject Headings]skin and connective tissue diseaseslcsh:ScienceMultidisciplinary:Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus Systemic [Medical Subject Headings]Predisposición genética a la enfermedad:Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease [Medical Subject Headings]PhenotypeInterferon Regulatory FactorsSYSTEMIC SCLEROSISMedicineEvaluation of complex medical interventions Auto-immunity transplantation and immunotherapy [NCEBP 2]FemaleIRF5; SLE; TYPE I INTERFERON; SYSTEMIC SCLEROSISHaplotiposResearch ArticleFactores de riesgoImmunology:Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins Signal Transducing::Interferon Regulatory Factors [Medical Subject Headings]:Check Tags::Male [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings]Single-nucleotide polymorphismHuman leukocyte antigenBiologyPolymorphism Single NucleotideWhite PeopleAutoimmune DiseasesRheumatologyLupus eritematoso sistémicoGeneticsHumansGenetic Predisposition to DiseaseGrupo de ascendencia continental europeaAlleleBiologyAllele frequencyAllelesGenetic Association Studies:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]Scleroderma SystemicHaplotypelcsh:R:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genetic Loci [Medical Subject Headings]Human Genetics:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]Factores reguladores del interferónHaplotypesDesequilibrio de ligamiento:Check Tags::Female [Medical Subject Headings]Genetic LociTYPE I INTERFERONGenetics of DiseaseImmunologyGenetic PolymorphismClinical Immunologylcsh:Q:Phenomena and Processes::Genetic Phenomena::Gene Frequency [Medical Subject Headings]Population GeneticsIRF5PLoS ONE
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Pilot study on the validity of the pupillographic sleepiness test in children and adolescents

2013

Abstract Objective To report preliminary validation data for the pupillographic sleepiness test (PST) in children and adolescents. Methods Twelve patients (13.1±4.4years of age) underwent the multiple sleep latency test (MLST) and three PSTs at 09:00, 11:00, and 13:00 on one single day. Correlations were tested between mean sleep latency and gender-adjusted z -values of the natural logarithm of the pupillary unrest index (zlnPUI). Results Spearman's correlation ( P -value) between the zlnPUI values obtained at 09:00 and 11:00 with the MSL was r S =−0.641 (0.025) and r =−0.553 (0.062). Conclusion There was satisfactory agreement between PST and the MLST, which is similar to what is found in …

MaleMultiple Sleep Latency Testmedicine.medical_specialtyFuture studiesAdolescentmedicine.diagnostic_testReproducibility of ResultsPilot ProjectsPupilDisorders of Excessive SomnolenceGeneral MedicineTest (assessment)CorrelationPhysical therapymedicineHumansPupillographyFemaleWakefulnessChildPsychologySleep Medicine SpecialtySleep Medicine
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Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness…

2021

Objectives: To report validation data for the Pupillographic Sleepiness Test (PST) in children and adolescents, evaluate its applicability for diagnosing excessive daytime sleepiness and its relationship to sleepiness-associated outcomes. Methods: A cross-sectional diagnostic test accuracy study was performed. Patients underwent three PST at 9 a.m. (T1), 11 a.m. (T2) and 1 p.m. (T3) plus the Multiple Sleep Latency Test (MSLT) on a single day. Additionally, two neurocognitive tests were performed and three questionnaires about quality of life, sleep-related self-efficacy and behavioural aspects completed. Gender-stratified z-values of the natural logarithm of the Pupillary Unrest Index (z-ln…

MaleMultiple Sleep Latency Testmedicine.medical_specialtySleepinessAdolescentExcessive daytime sleepinessDisorders of Excessive SomnolenceAudiologyDaytime sleepinessCorrelation03 medical and health sciences0302 clinical medicineQuality of lifeHumansMedicineWakefulnessChildSleepiness testingRank correlationHypersomniaCentral nervousReceiver operating characteristicmedicine.diagnostic_testPupillographybusiness.industryArea under the curveGeneral MedicineAlertnessCross-Sectional Studies030228 respiratory systemQuality of LifePupillographyactivationFemalemedicine.symptombusiness030217 neurology & neurosurgerySleep Medicine
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Surgical planning after sleep versus awake techniques in patients with obstructive sleep apnea

2013

Objective/Hypothesis This study examined correlations between surgical recommendations based on either drug-induced sleep endoscopy (DISE) or common awake examination methods in patients with obstructive sleep apnea syndrome (OSAS). Study Design Prospective, blinded, clinical trial at a university hospital. Methods An otorhinolaryngologist designed surgical plans for patients with OSAS after clinical examination, lateral cephalometry, the Muller maneuver, and Friedman staging. A second otorhinolaryngologist blinded to the previous plans made surgical recommendations after DISE. A third person tested agreement between the two sets of plans using Cohen's kappa statistic and the chi-squared te…

MaleMüller's maneuvermedicine.medical_specialtymedicine.medical_treatmentPhysical examinationSurgical planningPatient Care PlanningPreoperative CaremedicineHumansSingle-Blind MethodProspective StudiesWakefulnessSleep Apnea Obstructivemedicine.diagnostic_testbusiness.industryMiddle AgedAirway obstructionmedicine.diseaseLaryngeal ObstructionSurgeryObstructive sleep apneaClinical trialOtorhinolaryngologyCephalometryFemaleSleepbusinessThe Laryngoscope
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Efficacy of Buffered Hypertonic Saline Nasal Irrigation for Nasal Symptoms in Children with Seasonal Allergic Rhinitis: A Randomized Controlled Trial

2017

<b><i>Background:</i></b> Saline nasal irrigation is labelled as an add-on treatment in patients with allergic rhinitis (AR). The primary aim of this study was to compare the efficacy of 21-day use of buffered hypertonic saline (BHS) versus normal saline solution (NSS) on reducing nasal symptoms in children with seasonal AR (SAR). Comparing their efficacy on nasal cytology counts (NCC), quality of life, and sleep quality was the secondary aim. <b><i>Methods:</i></b> In this 21-day,<b> </b>open-label, randomized controlled study, 36 SAR children (aged 6-13 years) with a Total 5 Symptom Score (T5SS) ≥5 received twice-daily BHS or NSS…

MaleNeutrophilsmedicine.medical_treatmentSodium ChlorideGastroenterologylaw.inventionPittsburgh Sleep Quality IndexLeukocyte Count0302 clinical medicineQuality of lifeRandomized controlled triallawSurveys and QuestionnairesBuffered hypertonic solutionImmunology and AllergyChild030223 otorhinolaryngologyChildrenSalineHypertonicRhinitisNasal symptomGeneral MedicineNasal irrigationTreatment OutcomeNasal cytologyFemaleSaline SolutionNasal symptomsQuality of lifemedicine.medical_specialtyAdolescentSeasonal allergic rhinitisImmunology03 medical and health sciencesAllergicBuffered hypertonic solution; Children; Nasal cytology; Nasal symptoms; Quality of life; Seasonal allergic rhinitis; Adolescent; Child; Eosinophils; Female; Humans; Leukocyte Count; Male; Nasal Lavage; Neutrophils; Quality of Life; Rhinitis Allergic Seasonal; Saline Solution Hypertonic; Sodium Chloride; Surveys and Questionnaires; Treatment Outcome; Immunology and Allergy; ImmunologyInternal medicinemedicineHumansSaline Solution HypertonicSeasonalbusiness.industryRhinitis Allergic SeasonalNasal symptomsHypertonic salineEosinophils030228 respiratory systemNasal cytologyImmunologyNasal LavagebusinessInternational Archives of Allergy and Immunology
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Early and mid-term effects of obstructive apneas in myocardial injury and inflammation.

2011

Abstract Background Obstructive sleep apnea (OSA) is associated with cardiovascular disorders, but the different comorbidities in OSA patients make it difficult to know their specific effects on the development of cardiovascular injury. The aim of the present study was to investigate whether recurrent obstructive apneas could lead to myocardial injury. Methods Thirty-six male Sprague–Dawley rats (300–350 g) were either acutely (3 h) or sustainably (5 h/day, for 10 days) subjected to obstructive apneas with a pattern of 15 s each, 60 apneas/h. Corresponding control groups were formed for the acute and sustained models. To assess the induction of systemic inflammation, IL1-β was measured in p…

MaleObstructive sleep apnea Myocardial injury Inflammation Animal modelsmedicine.medical_specialtyPathologyHeart diseaseHeart DiseasesInterleukin-1betaInflammationApoptosisSettore MED/10 - Malattie Dell'Apparato RespiratorioSystemic inflammationRats Sprague-DawleyInternal medicinemedicineAnimalsInflammationSleep Apnea Obstructivebusiness.industryMyocardiumSleep apneaGeneral Medicinemedicine.diseaseRatsObstructive sleep apneaDisease Models AnimalApoptosisInitial phaseAcute DiseaseCardiologyDisease ProgressionCardiovascular Injurymedicine.symptombusinessSleep medicine
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Rapid maxillary expansion and obstructive sleep apnea: a review and meta-analysis

2016

Background: OSAS during childhood leads to significant physical and neuropsychomotor impairment. Thus, it needs to be recognized and treated early in order to avoid or attenuate the chronic problems associated with OSAS, which are deleterious to a child’s development. Adenotonsillectomy and, in select cases, continuous positive airwaypressure (CPAP) have been the preferred treatments for OSAS in children, and yet they are ineffective at fully ameliorating the disease. Minimally invasive treatments have recently been proposed, comprising intra-oral and extra-oral devices as well as speech therapy. Objetive: to conduct a meta-analysis on studies from around the world that used rapid maxillary…

MalePalatal Expansion Techniquemedicine.medical_specialtyPediatricsPolysomnographymedicine.medical_treatmentOdontologíaReviewDiseasePolysomnographyAdenoidectomy03 medical and health sciences0302 clinical medicineAdenoidectomymedicineHumansRapid maxillary expansionChildGeneral DentistryTonsillectomySleep Apnea ObstructiveOral Medicine and Pathologymedicine.diagnostic_testbusiness.industrySleep apnea030206 dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludnervous system diseasesSurgeryTonsillectomyrespiratory tract diseasesObstructive sleep apneaOtorhinolaryngologyMeta-analysisUNESCO::CIENCIAS MÉDICASFemaleSurgerybusiness030217 neurology & neurosurgery
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Influence of age and gender on reference values for common pediatric sleep questionnaires: Results from a community-based study.

2017

Abstract Objectives Sleep problems are often assessed using questionnaires, but it is unclear whether the responses given are influenced by age and gender. We addressed this question in several widely used pediatric sleep questionnaires and provide age-dependent percentile curves. Methods Data of a community-based study in schoolchildren were reanalyzed (N = 163, 50% males, age 6–17 years). Children and their parents completed the Sleep-Related Breathing Disorder Scale (SRBDS) of the Pediatric Sleep Questionnaire, the Sleep Disturbance Scale for Children (SDSC), the Sleep Self Report (SSR) of the Children's Sleep Habits Questionnaire in a long and short version, the Epworth Sleepiness Scale…

MaleParentsSleep Wake DisordersPercentileAdolescent03 medical and health sciences0302 clinical medicineSex FactorsReference ValuesSurveys and QuestionnairesmedicineHumansChildSleep disorderbusiness.industryEpworth Sleepiness ScaleAge FactorsApneaGeneral Medicinemedicine.diseaseSleep in non-human animalsConfidence intervalQuantile regression030228 respiratory systemOtorhinolaryngologyReference valuesPediatrics Perinatology and Child HealthRegression AnalysisFemaleSelf Reportmedicine.symptombusinessSleep030217 neurology & neurosurgeryClinical psychologyInternational journal of pediatric otorhinolaryngology
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Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year pro…

2018

Abstract Objective Cross-sectional studies show a lower health-related quality of life (HRQoL) in individuals with narcolepsy. We aimed to describe changes in HRQoL after two years of multidisciplinary follow-up in a cohort of mainly post-H1N1 vaccination narcolepsy type-1 (NT1) patients in Norway. Methods Prospective-cohort study. Narcolepsy diagnosis was based on the International Classification of Sleep Disorders (third edition). Psychiatric comorbidity was assessed using the Achenbach System of Empirically Based Assessment (ASEBA). HRQoL was evaluated with the Pediatric Quality of Life Inventory (PedsQL™ Generic Core Scales 4.0) at baseline and follow-up. Mean follow-up time was 20.7 (2…

MalePediatricsmedicine.medical_specialtyAdolescentComorbiditySeverity of Illness IndexYoung Adult03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineQuality of lifeInfluenza HumanmedicineHumansInternational Classification of Sleep DisordersProspective Studies030212 general & internal medicineChildProspective cohort studyNarcolepsyImmunization ProgramsNorwaybusiness.industryVaccinationGeneral Medicinemedicine.diseasehumanitiesPeer reviewVaccinationCross-Sectional StudiesTest scoreCohortQuality of LifeFemaleSodium Oxybatebusiness030217 neurology & neurosurgeryAdjuvants AnesthesiaNarcolepsySleep Medicine
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Predicting poor school performance in children suspected for sleep-disordered breathing

2015

Habitually snoring children are at a greater risk of poor school performance (PSP). We investigated the ability of conventional sleep-disordered breathing (SDB) measures for predicting PSP in habitually snoring children.The dataset of Hannover Study on Sleep Apnea in Childhood (HASSAC), a large community-based study in primary school children, was retrospectively analyzed. All habitual snorers were included. Based on their grades, children were grouped into good and poor school performers. SDB measures obtained by a parental questionnaire, a home pulse oximetry, and a home polysomnography were evaluated for their accuracy in predicting poor school performance by calculating receiver operati…

MalePediatricsmedicine.medical_specialtyPolysomnographyChild BehaviorPolysomnographySleep Apnea SyndromesPredictive Value of TestsSurveys and QuestionnairesmedicineHumansOximetryChildRetrospective Studiesmedicine.diagnostic_testReceiver operating characteristicbusiness.industrySnoringSleep apneaRetrospective cohort studyGeneral Medicinemedicine.diseaserespiratory tract diseasesObstructive sleep apneaPulse oximetryPredictive value of testsPhysical therapyFemaleEducational MeasurementbusinessNeurocognitiveSleep Medicine
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