Search results for " aggregation"
showing 10 items of 441 documents
The formation of hybrid complexes between isoenzymes of glyceraldehyde‐3‐phosphate dehydrogenase regulates its aggregation state, the glycolytic acti…
2019
The glycolytic enzyme glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has been traditionally considered a housekeeping protein involved in energy generation. However, evidence indicates that GAPDHs from different origins are tightly regulated and that this regulation may be on the basis of glycolysis‐related and glycolysis‐unrelated functions. In Saccharomyces cerevisiae, Tdh3 is the main GAPDH, although two other isoenzymes encoded by TDH1 and TDH2 have been identified. Like other GAPDHs, Tdh3 exists predominantly as a tetramer, although dimeric and monomeric forms have also been isolated. Mechanisms of Tdh3 regulation may thus imply changes in its oligomeric state or be based in its abil…
Poly-sarcosine and poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations
2018
Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility. The molecular determinants of this reduction are not very well understood yet, and their knowledge may help improving nanoparticle design. Here we address, using molecular dynamics simulations, the interactions of human serum albumin, the most abundant serum protein, with two promising hydrophilic polymers used for the coating of therapeutic nanoparticles, poly(ethylene-glycol) and poly-sarcosine. By simulating the protein immersed in a polymer-water mixture, we show that the two polymers have a very similar affinity for the…
BSA Aggregation in Trehalose-Water Systems
2010
Introduction Recent studies [1] on ternary protein-trehalose-water samples have shown that the protein thermal denaturation temperature is linearly correlated with the glass transition temperature of the system, despite the quite large temperature difference between the two processes. In such studies it is stated that the collective, long range properties of the matrix that regulate the glass transition are strictly correlated with local features on which the denaturation of the protein depends. In order to ascertain whether an analogous correlation exists between the effects of trehalose on the protein’s aggregation process and the glass transition temperature of the system, we performed L…
Polyphenols extracted from three apple cultivars grown in Sicily: effect on k-casein aggregation
2016
Distributed Demand-Response Certification using Blockchain Technology
2021
e-Fair: Aggregation in e-Commerce for Exploiting Economies of Scale
2017
In recent years, many new and interesting models of successful online business have been developed, including competitive models such as auctions, where the product price tends to rise, and group-buying, where users cooperate obtaining a dynamic price that tends to go down. We propose the e-fair as a business model for social commerce, where both sellers and buyers are grouped to maximize benefits. e-Fairs extend the group-buying model aggregating demand and supply for price optimization as well as consolidating shipments and optimize withdrawals for guaranteeing additional savings. e-Fairs work upon multiple dimensions: time to aggregate buyers, their geographical distribution, price/quant…
An Efficient Retransmission Strategy for Data Gathering in Wireless Sensor Networks Authors
2005
This paper introduces a new strategy for data gathering in wireless sensor networks that takes into account the need for both energy saving and for a reasonable tradeoff between robustness and efficiency. The proposed algorithm implements an efficient strategy for retransmission of lost packets by discovering alternative routes and making clever use of multiple paths when necessary; in order to do that we use duplicate and order insensitive aggregation functions, and by taking advantage of some intrinsic characteristics of the wireless sensor networks, we exploit implicit acknowledgment of reception and smart caching of the data.
Information Organization and Visualization for the ALS Project
2010
This work presents the adopted methodology and the realized tools for data visualization in the Linguistic Atlas Of Sicily (ALS) Project. The ALS Project has the purpose to discovery new trends and variables to track the linguistic evolution over time and space in Sicily. The project is focused on how linguistic variables are related to social and economic aspects of the evolution of population and vice-versa. The visualization tools are a relevant aspect of the project to support decisions and disseminate results. One of the major factors is the geographic dependence of data evolution. To this aim complex set of tools has been developed: some tools are stand-alone while others are collabor…
A close connection: Alzheimer’s disease and type 2 diabetes
2012
In the recent years a growing body of evidence links insulin resistance and insulin action to neurodegenerative diseases, especially Alzheimer’s disease (AD). The importance of insulin in ageing as well as its role in cognition and other aspects of normal brain functions are well established. The hippocampus and cerebral cortex-distributed insulin and insulin receptor (IR) have been shown to be involved in brain cognitive functions. Conversely, deterioration of IR signaling is involved in agingrelated brain degeneration such as in AD and cognitive impairment in type 2 diabetes patients. Insulin administration, while maintaining euglycemia, improves memory in both healthy adults and Alzheime…
A BoD Composite Indicator to Measure the Italian “Sole 24 Ore” Quality of Life
2023
The measure of Quality of Life (QoL) is still a topic widely discussed in literature. In Italy, the newspaper “Il Sole 24 Ore” publishes a famous ranking that highlights strong disparities among provinces. In this paper, “Il Sole 24 Ore” and BoD-DEA methods are compared in order to show how different types of normaliza- tion and aggregation significantly influence the results making these rankings very fragile and questionable.