Search results for " bet"

Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.

2014

Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …

Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation.

1995

Only recently, evidence was provided that apolipoprotein E allele epsilon 4 located on Chromosome 19 is associated with late onset (i.e. senile) sporadic Alzheimer's disease. Histologically, Alzheimer's disease is associated with intraneuronal neurofibrillary changes and extraneuronal A4/beta-amyloid deposition. We set out with a histological staging system which considers the gradual development of Alzheimer's disease-related histological changes over time and correlates highly with the cognitive decline ante mortem. Our analysis revealed that both the mean stage for A4/beta-amyloid deposits and the mean stage for neurofibrillary tangles get significantly shifted upwards in epsilon 4-carri…

The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma

2016

Unit Interval Time and Magnitude Monitoring Using Beta and Unit Gamma Distributions

2022

Quick detection of an assignable cause is necessary for process accuracy with respect to the specifications. The aim of this study is to monitor the time and magnitude processes based on unit-interval data. To this end, maximum exponentially weighted moving average (Max-EWMA) control chart for simultaneous monitoring time and magnitude of an event is proposed. To be precise, beta and unit gamma distributions are considered to develop the Max-EWMA chart. The chart’s performance is accessed using average run length (ARL), the standard deviation of run length (SDRL), and different quantiles of the run length distribution through extensive Monte Carlo simulations. Besides a comprehensive simula…

Asset rating: Disagreement between the results obtained from software for energy certification

2009

The general practice for establishing the consumption in asset ratings of a building consists of entrusting the energy analysis of the shell of a building to calculating software. The building is the subject of an extremely complicated analysis, and there are many variables at stake, is it more correct to aim for a simplification of the problem, in the knowledge that behind every analytical formula there is the possibility of an evaluation error, or is it better to aim for calculation models that are more and more detailed in an attempt to succeed in predicting the real energy behaviour of the building ? Depending on the objective that has been set, it is a good idea to identify the tool be…

Zvaigžņotā Debess: 2009, Rudens (205)

2009

Contents: I.Daube. Jānis Ikaunieks ; A.Balklavs. Mountains on the Venus ; TASS and “Pravda” materials. Soviet Automatic Stations “Venera-5” and “Venera-6” Reach Venus ; A.Alksnis. Gathering of Astronomers at the University ; A.Alksnis, M.Ābele, I.Eglītis, B.Rjabovs, K.Salmiņš, I.Pundure. Directions of Scientific Research of the UL Institute of Astronomy Assessed ; D.Docenko. Meteorite Fallen in Sudan Recovered ; A.Alksnis. How Asteroids Will Disturb Observation with Extremely Large Telescopes ; M.Gills. Daily in Network with Astronomy ; I.Pundure. Arturs Balklavs and Astronomy of Latvia (continued) ; M.Sudārs. IXV – Step towards Reusable Space Vehicles ; V.Kalniņš. Hyperdrive and Heim’s Qua…

Beta Decay Studies of Neutron Rich Nuclei Using Total Absorption Gamma-ray Spectroscopy and Delayed Neutron Measurements

2010

International audience; A complete characterisation of the β-decay of neutron-rich nuclei can be obtained from the measurement of β-delayed gamma rays and, whenever the process is energetically possible, β-delayed neutrons. The accurate determination of the β-intensity distribution and the β-delayed neutron emission probability is of great relevance in the fields of reactor technology and nuclear astrophysics. A programme for combined measurements using the total absorption gamma-ray spectroscopy technique and both neutron counters and neutron time-of-flight spectrometers is presented.

Discovery potential of xenon-based neutrinoless double beta decay experiments in light of small angular scale CMB observations

2013

The South Pole Telescope (SPT) has probed an expanded angular range of the CMB temperature power spectrum. Their recent analysis of the latest cosmological data prefers nonzero neutrino masses, with Sigma m(nu) = (0.32 +/- 0.11) eV. This result, if con firmed by the upcoming Planck data, has deep implications on the discovery of the nature of neutrinos. In particular, the values of the effective neutrino mass m(beta beta) involved in neutrinoless double beta decay (beta beta 0 nu) are severely constrained for both the direct and inverse hierarchy, making a discovery much more likely. In this paper, we focus in xenon-based beta beta 0 nu experiments, on the double grounds of their good perfo…

Neutrino masses and their ordering: global data, priors and models

2018

We present a Bayesian analysis of the combination of current neutrino oscillation, neutrinoless double beta decay and CMB observations. Our major goal is to carefully investigate the possibility to single out one neutrino mass ordering, Normal Ordering or Inverted Ordering, with current data. Two possible parametrizations (three neutrino masses versus the lightest neutrino mass plus the two oscillation mass splittings) and priors (linear versus logarithmic) are examined. We find that the preference for NO is only driven by neutrino oscillation data. Moreover, the values of the Bayes factor indicate that the evidence for NO is strong only when the scan is performed over the three neutrino ma…

Double-beta-decay nuclear matrix elements in the QRPA framework

2012

We review the recent work done by the Jyväskylä-La Plata collaboration on the calculation of nuclear matrix elements for various modes of double-beta decays. Whenever helpful, we connect our recent work to the historical background in order to highlight the progress achieved in the field of double-beta decay. At the same time, we introduce some new concepts and ideas to treat e.g. possible backgrounds in Gamow-Teller strength functions generated in (p,n) and (n,p) reactions. © 2012 IOP Publishing Ltd. Fil: Suhonen, J.. Universidad de Jyvaskyla; Finlandia Fil: Civitarese, Enrique Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La P…