Search results for " bet"
showing 10 items of 1744 documents
Descriptor-type Robust Kalman Filter and Neural Adaptive Speed Estimation Scheme for Sensorless Control of Induction Motor Drive Systems
2012
Abstract This paper deals with robust estimation of speed and rotor flux for sensorless control of motion control systems which use induction motors as actuators. Due to the observability lack of five and six order Extended Kalman Filters, speed is here estimated by means of a Total Least Square algorithm with Neural Adaptive mechanism. This allows the use of a fourth-order Kalman Filter for estimating rotor flux and to filter stator currents. To cope with motor-load parameter variations, a descriptor-type robust Kalman Filter is designed taking explicitly into account these variations. The descriptor-type structure allows direct translation of parameter variations into variations of the co…
Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1-42) peptides and dimeric splitting phenomena.
2022
International audience; The Aβ(1-42) aggregation is a key event in the physiopathology of Alzheimer's disease (AD). Exogenous factors such as environmental pollutants, and more particularly pesticides, can corrupt Aβ(1-42) assembly and could influence the occurrence and pathophysiology of AD. However, pesticide involvement in the early stages of Aβ(1-42) aggregation is still unknown. Here, we employed conical track-etched nanopore in order to analyse the Aβ(1-42) fibril formation in the presence of pyrimethanil, a widely used fungicide belonging to the anilinopyrimidine class. Our results evidenced a pro-aggregating effect of pyrimethanil on Aβ(1-42). Aβ(1-42) assemblies were successfully d…
Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production
2004
Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID. Many COX-2-selective NSAIDs tested raised Abeta42, including multiple COX-2-selective derivatives of two Abeta42-lowering NSAIDs. Compounds devoid of COX activity and the endogenous isoprenoids FPP and GGPP also raised Abeta42. These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro. Short-term in vivo studies show that two Abeta42-raising comp…
TGF-beta regulates airway responses via T cells.
2003
Abstract Allergic asthma is characterized by airway hyperreactivity, inflammation, and a Th2-type cytokine profile favoring IgE production. Beneficial effects of TGF-β and conflicting results regarding the role of Th1 cytokines have been reported from murine asthma models. In this study, we examined the T cell as a target cell of TGF-β-mediated immune regulation in a mouse model of asthma. We demonstrate that impairment of TGF-β signaling in T cells of transgenic mice expressing a dominant-negative TGF-β type II receptor leads to a decrease in airway reactivity in a non-Ag-dependent model. Increased serum levels of IFN-γ can be detected in these animals. In contrast, after injection of OVA …
Microsomal and cytosolic epoxide hydrolases, the peroxisomal fatty acid beta-oxidation system and catalase. Activities, distribution and induction in…
1988
A number of structurally unrelated hypolipidaemic agents and certain phthalate-ester plasticizers induce hepatomegaly and proliferation of peroxisomes in rodent liver, but there is relatively limited data regarding the specific effects of these drugs on liver non-parenchymal cells. In the present study, liver parenchymal, Kupffer and endothelial cells from untreated and fenofibrate-fed rats were isolated and the activities of two enzymes associated with peroxisomes (catalase and the peroxisomal fatty acid beta-oxidation system) as well as cytosolic and microsomal epoxide hydrolase were measured. Microsomal epoxide hydrolase, cytosolic epoxide hydrolase and catalase activities were 7-12-fold…
Evaluating the effects of forest tree species on rill detachment capacity in a semi-arid environment
2021
Abstract The beneficial effects of plant roots in decreasing soil detachment in forest ecosystems exposed to rill erosion are well known. However, these effects vary largely between different plant species. There has been lots of research into the relationship between root-soil systems and rill erodibility with a particular focus on grass species. Conversely, fewer studies are available for tree species, especially in forests of semi-arid or arid environments. Greater knowledge is therefore needed to identify the most effective tree species against rill erosion in these ecosystems, where water availability is the limiting factor for vegetation growth and afforestation is often the only solu…
LABA/LAMA fixed-dose combinations in patients with COPD: A systematic review
2018
Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Græcia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Italy; 7…
Concurrent and lagged effects of counterdispositional extraversion on vitality
2020
Abstract There are two contrasting perspectives on the effects of state extraversion. One states that people benefit from behaving extraverted, regardless of their level of trait extraversion. The second entails that behaving concordant to one’s trait is natural while deviations from the trait level— counterdispositional behaviors—are effortful to maintain, leading to mental fatigue. We test the possibility that both perspectives are correct, with beneficial effects of high state extraversion showing immediately, while the depleting counterdispositional effects are delayed. Experience sampling data from 67 employees (N = 1,664), shows that extraverted behaviors are associated with high leve…
Counterdispositional Conscientiousness and Wellbeing: How Does Acting Out of Character Relate to Positive and Negative Affect at Work?
2020
Conscientiousness is typically seen as a positive or desired personality trait in the workplace, with the overall assumption being “the more, the better”. Drawing on the behavioral concordance model, we challenge this assumption, expecting that the highest level of positive affect and the lowest level of negative affect will correspond at the point where state and trait conscientiousness converge. Using an experience sampling study and an event reconstruction study, we show that deviations from one’s level of trait conscientiousness relate to variations in positive and negative affect, but not in a straightforward way. While wellbeing was lower when people behaved less conscientiously than …
Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients
2020
Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation. Extracorporeal shock waves (ESW) increase cell proliferation and differentiation of connective tissue fibroblasts. To date no studies are available on ESW treatment of human bronchial fibroblasts and epithelial cells from COPD and control subjects. We obtained primary bronchial fibroblasts from bronchial biopsies of 3 patients with mild/moderate COPD and 3 control smokers with normal lung function. 16HBE cells were also studied. Cells were treated with a…