Search results for " investigation"

Investigational agents for Crohn's disease.

2010

IMPORTANCE OF THE FIELD: Increased understanding of the biological mechanisms of Crohn's disease has opened the door to a large number of new molecules; some of these are approved for clinical use, while others remain under evaluation. In this review, we examine the clinical efficacy of all the new drugs that have been evaluated in controlled trials in the last 12 years. AREAS COVERED IN THIS REVIEW: Anti-TNF therapy has been reviewed briefly, given the many comprehensive reviews on this topic; attention is focused mainly on the other biological therapies. In assessing the clinical efficacy of these molecules, we consider only the remission rate, as this is considered the most meaningful en…

PO-0965: Clinical investigation of inter seed attenuation effects in prostate I-125 seed implant brachytherapy

2013

Environmental facilitators for outdoor walking and development of walking difficulty in community-dwelling older adults

2013

Older adults who report environmental barriers in their neighborhood have a higher risk for walking difficulty. However, environmental facilitators that protect against walking difficulty are not well known. The objective of this study was to identify the effect of environmental facilitators for outdoor walking on development of walking difficulty in community-dwelling older people. This was a prospective study with a 3.5-year follow-up time on 261 community-dwelling people aged 75–81 years, who at baseline were able to walk 0.5 km without difficulty. Environmental facilitators for outdoor walking were self-reported with standardized questionnaires, including having features in one’s home w…

Case Report: Unusual Clinical Presentation of a Rare Cardiac Inflammatory Myofibroblastic Tumor in Children: The Differential Diagnosis With Pediatri…

2021

Introduction: There are still no guidelines about pediatric cardiac cancers. The purpose of this work is to provide new scientific data facilitating the differential diagnosis of a rare cardiac tumor with an unusual presentation, such as the cardiac inflammatory myofibroblastic tumor (IMT).Case Presentation: A 3-year-old male child presented with several symptoms including unconsciousness, vomiting, and drowsiness. A clinical and neurological examination revealed a unilateral (right) motor delay and positive unilateral Babinski sign. Electrocardiogram (ECG) was normal.Diagnostic Assessment: The total body computed tomography (CT) scans showed hypodensity in the left temporal–parietal lobe, …

An International, Multicenter Retrospective Observational Study to Assess Technical Success and Clinical Outcomes of Patients Treated with an Endovas…

2022

Introduction: Type III endoleaks post-endovascular aortic aneurysm repair (EVAR) warrant treatment because they increase pressure within the aneurysm sac leading to increased rupture risk. The treatment may be difficult with regular endovascular devices. Endovascular aneurysm sealing (EVAS) might provide a treatment option for type III endoleaks, especially if located near the flow divider. This study aims to analyze clinical outcomes of EVAS for type III endoleaks after EVAR. Methods: This is an international, retrospective, observational cohort study including data from 8 European institutions. Results: A total of 20 patients were identified of which 80% had a type IIIb endoleak and the r…

Serological and molecular identification of Legionella spp. isolated from water and surrounding air samples in Italian healthcare facilities

2016

Abstract Background Legionella is an intracellular microorganism living in natural and artificial aquatic environments. Although its transmission to humans is linked to the inhalation of contaminated aerosols, there is no validated air sampling method for the control and prevention of the disease. The aim of the present study was to provide more information on the distribution of Legionella spp. in indoor environments and to determine whether the same Legionella strains are isolated from air and water samples. Methods Ten healthcare facilities located in seven regions of Italy were enrolled. The serological typing of Legionella spp. from water samples and the surrounding air by active and p…

Monitoring Biological Damage on Paper-based Documents in the Historical Archive of the Palermo Astronomical Observatory

2017

Libraries and archives house a wide variety of documents made of materials of vegetal and animal origin: unbound papers and books, manuscripts and printed books, photographs (negative and positive), prints, maps, available to the public for reading needs, study and information. These materials are often subject to fluctuations in environmental and micro-environmental parameters. For this reason, it is essential to implement constant monitoring and control of environmental conditions and potential deteriogens in order to slow down deterioration processes. The monitoring of the microbial degradation of paper documents in the Historical Archives of Palermo Astronomical Observatory has revealed…

Principios rectores en la adopción de diligencias limitativas de los derechos reconocidos en el art. 18 ce

2021

Criminal Procedure Law reform carried out in 2015 requires, in order to adopt the investigation proceedings that limit the rights recognized by art. 18 Spanish Constitution, to respect the guiding principles of specialty, suitability, exceptionality, necessity and proportionality. This article aims, departing from the legal text and considering existing jurisprudence, to unveil the true meaning of these principles.

New insight on metal finds of the Punic Ship of Lilibeum

2020

In this paper, the investigation of some finds (two nails, a head and a long shaft nail, and a fragment of Lead sheathing) belonging to the wreck of the Punic ship and exhibited at Museo Archeologico Regionale Lilibeo (Trapani, Italy), is reported. The X-ray Fluorescence Spectroscopy (XRF) allowed us to identify the elements constituting them making some discussion deductions about their composition and degradation occurred.

Efficacy of Oxybrasion and Cosmetic Acids on Selected Skin Parameters in the Treatment with Acne Vulgaris

2023

Karolina Chilicka,1 Monika Rusztowicz,1 Aleksandra M Rogowska,2 Renata Szyguła,1 Danuta Nowicka3 1Department of Health Sciences, Institute of Health Sciences, University of Opole, Opole, Poland; 2Department of Social Sciences, Institute of Psychology, University of Opole, Opole, Poland; 3Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, PolandCorrespondence: Karolina Chilicka, Department of Health Sciences, Institute of Health Sciences, University of Opole, Katowicka 68 Street, Opole, 45-040, Poland, Tel +48665439443, Email karolina.chilicka@uni.opole.plPurpose: The present study aimed to evaluate the efficacy of an…