Search results for " multiple"

Isomeric arrangement of the left atrial appendages and visceral heterotaxy: two atypical cases.

2000

AbstractWe present two cases in which there was isomeric arrangement oi the left atrial appendages in association with multiple spleens and complete heart block. In both of these, the venous connections were normal. In one case the arrangement of the bronchial tree and the lungs was normal, the liver was left-sided, and the stomach was right-sided. In the other case, there was left isomeric broncho-pulmonary morphology, and both liver and stomach were right-sided. These unusual combinations show the need for full description of the morphology of other organs, and the venoatrial connections, in cases with isomeric arrangement of the atrial appendages. They also demonstrate that connection of…

On the existence and multiplicity of solutions for Dirichlet's problem for fractional differential equations

2016

In this paper, by using variational methods and critical point theorems, we prove the existence and multiplicity of solutions for boundary value problem for fractional order differential equations where Riemann-Liouville fractional derivatives and Caputo fractional derivatives are used. Our results extend the second order boundary value problem to the non integer case. Moreover, some conditions to determinate nonnegative solutions are presented and examples are given to illustrate our results.

Arbitrage international. Arbitrage multiparties, Groupe de contrats, Clauses compromissoires incompatibles, Consolidation (non)

1991

International audience; (Versailles, 7 mars 1990, Rev. arb. 1991. 326, note Loquin)

Distal Arthrogryposis type 5 in an Italian family due to an autosomal dominant gain-of-function mutation of the PIEZO2 gene

2022

Abstract Background Arthrogryposis multiplex congenita (AMC) is a group of clinically and etiologically heterogeneous conditions, characterized by prenatal onset contractures affecting two or more joints. Its incidence is about 1 in 3000 live births. AMC may be distinguished into amyoplasia, distal and syndromic arthrogryposis. Distal arthrogryposis (DA) predominantly affects hands and feet. It is currently divided into more than ten subtypes (DA1, DA2A/B, DA3–10), based on clinical manifestations, gene mutations and inheritance pattern. Among them, only a few patients with DA5 have been reported. It is associated to a gain-of-function pathogenic variant of the PIEZO2 gene, encoding for an …

Role of Hsp70 in Multiple Sclerosis: An Overview

2019

For many years heat shock protein 70 (Hsp70) was considered exclusively an intracellular chaperone contributing to protein proteostasis and in apoptotic pathway block. Lately it has been demonstrated that Hsp70 is actively released in the extracellular environment, thereby promoting the activation of the immune system by stimulating innate and adaptive responses through the activation of APCs. Its expression in the nervous system is induced in a variety of pathological conditions. Emerging evidences displayed that Hsp70 is a critical regulator in normal neural cells. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) directed against myelin antigens. In thi…

Natural Triterpene Glycosides for Antibody Recognition

2016

Multiple sclerosis is an autoimmune disease that affects the central nervous system. The key role of the glycosylation in disease pathogenesis has been previously studied and the synthetic N-glucosylated peptide CSF114(Glc) proved its efficiency in autoantibody recognition in the sera of multiple sclerosis patients. Herein, pure natural triterpene glycosides containing different glycosyl moieties were isolated and tested in multiple sclerosis patientsʼ sera to better understand the role of glycosylation. They were selected taking into account the nature and complexity of their osidic part. Five triterpene glycosides were isolated from several plants with more than 95 % purity. The interacti…

On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds

2019

The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it emerged simultaneously on three continents, with each clade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed.The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it emerged simultaneously on three continents, with each clade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed. In this study, we used phylogeneti…

Multi-level responses of Mytilus galloprovincialis to environmental stressors

2019

Religious spaces as continually evolving modernities: Forms of encounter with modernity in Christian Orthodoxy and Islam

2022

The present study deals with the encounter with modernity in two neighbouring religious spaces: Christian Orthodoxy and Islam. Relying on Eisenstadt’s theory about multiple modernities and on its further developments by Thomas Mergel and Kristina Stoeckl, Islamic and Christian-Orthodox dynamics in relation to the challenges of modernity are examined under two aspects: first, the decoupling between religion and culture as elaborated by Olivier Roy, and second, the development of modernist and fundamentalist currents as phenomena of modernity. The study contributes to the sketching of the profile of Islamic and the Christian-Orthodox modernities, pointing both to some of the commonalities and…

Applicability of Interference Coordination in Highly Loaded HSUPA Network

2010

This paper evaluates the performance of highly loaded High Speed Uplink Packet Access (HSUPA) network with and without network wide static Interference Coordination (IC). IC alternates the priorities for user transmission periods throughout the network to achieve reduced interference levels and higher performance. A large variety of combinations including, e.g., different schedulers, cell center/edge user definitions (user splits) and interference targets are investigated in this paper. Performance is analyzed using a quasi-static system level simulator which is also used to support Third Generation Partnership Project (3GPP) standardization work. The simulator contains detailed and commonl…