Search results for " regulation."

The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.

2014

β-Catenin is a central effector of the Wnt pathway and one of the players in Ca(+)-dependent cell-cell adhesion. While many wnts are present and expressed in vertebrates, only one β-catenin exists in the majority of the organisms. One intriguing exception is zebrafish that carries two genes for β-catenin. The maternal recessive mutation ichabod presents very low levels of β-catenin2 that in turn affects dorsal axis formation, suggesting that β-catenin1 is incapable to compensate for β-catenin2 loss and raising the question of whether these two β-catenins may have differential roles during early axis specification. Here we identify a specific antibody that can discriminate selectively for β-…

Banche e mercato del credito in Italia: tendenze di mercato, prospettive regolamentari e processi di disintermediazione.

2020

Il capitolo vuole fornire alcuni spunti di riflessione sulle tendenze del mercato del credito in Italia e sulle nuove prospettive regolamentari, in relazione alle innovazioni di carattere istituzionale e di mercato in atto nel sistema bancario italiano, adottando una prospettiva di osservazione che è quella dell’economia della banca. Nella prima parte saranno illustrate le dinamiche che hanno contrassegnato il mercato del credito italiano, nonché i principali profili gestionali relativi ai crediti deteriorati. Nella seconda parte saranno esaminati gli impatti sul mercato del credito delle nuove regole di vigilanza prudenziale, delle nuove regole contabili e sul capitale delle banche, i proc…

Crisi economica e vigilanza unica europea sulle banche: alcuni riflessi sul mercato dei servizi finanziari.

2015

This paper aims to examine some significant implications of the new European single banking supervision for the economics of banking and the market of financial services. It is one of the three pillars of the European Banking Union architecture, as part of a longer term vision for further economic and monetary integration in EU. The new supervisory mechanisms implies a huge and complex transfer of powers from national authorities to the European Central Bank. It aims to ensure the safety and soundness of the European banking system, increase financial integration and stability, and ensure consistent supervision. Banks are being held to common supervisory standards. The structure of this pap…

Theory and regulation of liquidity risk management in banking

2016

Liquidity risk is now more important than it used to be in the past. The financial crisis has emphasised the importance of liquidity risk to the functioning of banking and financial system. The paper presents a theoretical and regulatory investigation of two types of liquidity risk: funding liquidity risk and market liquidity risk. The paper analyses the different approaches to measure the impact of funding and market liquidity risk in the economics and management of banks. The paper provides also an analysis of the organisational implications of the asset and liability management perspective of liquidity risk. Liquidity risk does not need to be covered by equity but by an adequate volume o…

Gli strumenti di better regulation nella giurisprudenza costituzionale e amministrativa

2021

Lo scopo del capitolo è quello di esaminare il contributo della giurisprudenza costituzionale e di quella amministrativa nel rafforzamento dell'uso degli strumenti di better regulation nell'adozione degli atti normativi in Italia nell'anno 2020. The purpose of the Chapter is to examine the contribution of the Constitutional Court and the administrative judge for the use of better regulation tools in adoption of legislative and regulatory acts in Italy in 2020.

Urate as effector for crustacean hemocyanins.

2004

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

2001

Methylating carcinogens and cytostatic drugs induce different methylation products in DNA. In cells not expressing the repair protein MGMT or expressing it at a low level, O6-methylguanine is the major genotoxic, recombinogenic, and apoptotic lesion. Genotoxicity and apoptosis triggered by O6-methylguanine require mismatch repair (MMR). In cells expressing O6-methylguanine-DNA methyl transferase (MGMT) at a high level or for agents producing low amounts of O6-methylguanine, N-alkylations become the major genotoxic lesions. N-Alkylations are repaired by base excision repair (BER). In mammalian cells, naturally occurring mutants of BER have not been detected, which points to the importance of…

Molecular Structure of the Arthropod Hemocyanins

1992

Hemocyanin is an extracellular, blue protein that occurs in high concentrations in the blood of many arthropods, including spiders, scorpions, horseshoe crabs, crustaceans, and at least two centipedes. Serving as an ### oxygen carrier, it is functionally equivalent to hemoglobin, but performs reversible oxygen binding between two copper ions. Hemocyanin is composed of a number of subunits that assemble in an extremely large macro-molecular entity. These particles, which are similar in size to viruses or ribosomes, exhibit a complex allosteric behavior during oxygen binding. There is growing evidence that this functional plasticity has evolved upon, and answers to, ecophysiological constrain…

Identification of Stress Associated microRNAs in

2019

Tomato (Solanum lycopersicum) is one of the most important crops around the world and also a model plant to study response to stress. High-throughput sequencing was used to analyse the microRNA (miRNA) profile of tomato plants undergoing five biotic and abiotic stress conditions (drought, heat, P. syringae infection, B. cinerea infection, and herbivore insect attack with Leptinotarsa decemlineata larvae) and one chemical treatment with a plant defence inducer, hexanoic acid. We identified 104 conserved miRNAs belonging to 37 families and we predicted 61 novel tomato miRNAs. Among those 165 miRNAs, 41 were stress-responsive. Reverse transcription quantitative PCR (RT-qPCR) was used to valida…

Proton-irradiated breast cells: molecular points of view

2019

Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…