Search results for " solution"
showing 10 items of 3084 documents
Physicochemical stability of cabazitaxel containing premix solution and diluted infusion solutions
2015
Objectives This study was conducted to investigate the extended physicochemical stability of cabazitaxel containing premix solution and diluted infusion solutions in either 0.9% sodium chloride (NaCl) or 5% glucose (G5) vehicle solution. Methods A stability indicating, reverse phase, high performance liquid chromatography assay with ultraviolet detection was developed and validated. Premix solutions of cabazitaxel were prepared in the original vials. Infusion solutions were prepared in prefilled polypropylene/polyethylene (PP/PE) infusion bags (0.9% NaCl, G5) to achieve the recommended minimum and maximum cabazitaxel concentrations (0.1 mg/mL, 0.26 mg/mL). Test solutions were stored refrige…
Compared effects of synthetic and natural bile acid surfactants on xenobiotic absorption I. Studies with polysorbate and taurocholate in rat colon
1991
Some expected differences between synthetic and natural bile acid surfactants relative to their influences on xenobiotic absorption are briefly outlined on the basis of literature data. Then, experimental work is presented which shows that these differences exist and that they can be even more relevant than suspected. Absorption tests were developed in rat colon in situ with polysorbate (synthetic) and sodium taurocholate (natural) surfactants, using a homologous series of phenylalkylcarboxylic acids as test compounds. At the critical micelle concentration (CMC), the two previously reported actions of synthetic surfactants on xenobiotic absorption (i.e. the increase in absorbing membrane po…
Absorption-partition relationships for true homologous series of xenobiotics as a possible approach to study mechanisms of surfactants in absorption.…
1992
Abstract This paper — the latest in this series of reports — deals with the effects of the anionic surfactant sodium lauryl sulfate on the colonic absorption of acidic xenobiotics (phenylalkylcarboxylic acids), as compared with those exerted by the nonionic polysorbate 80. The effects of these surfactants are qualitatively identical but quantitatively different. Thus, the increase in polarity of the colonic absorbant membrane is greater with lauryl sulfate, whereas micellar solubilization is much higher with polysorbate. As for the rest (i.e. the elimination of the stagnant aqueous diffusion layer as a limiting step for absorption), the two surfactants behave in a similar way. The biopharma…
Zn-Enhanced Asp-Rich Antimicrobial Peptides N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides
2021
The antimicrobial activity of surfactant-associated anionic peptides (SAAPs), which are isolated from the ovine pulmonary surfactant and are selective against the ovine pathogen Mannheimia haemolytica, is strongly enhanced in the presence of Zn(II) ions. Both calorimetry and ITC measurements show that the unique Asp-only peptide SAAP3 (DDDDDDD) and its analogs SAAP2 (GDDDDDD) and SAAP6 (GADDDDD) have a similar micromolar affinity for Zn(II), which binds to the N-terminal amine and Asp carboxylates in a net entropically-driven process. All three peptides also bind Cu(II) with a net entropically-driven process but with higher affinity than they bind Zn(II) and coordination that involves the N…
Chapter 8 Native and Bonded Silicas in Aqueous Sec
1988
Publisher Summary This chapter deals with the properties of packings and columns in correlation to chromatographic separations in size exclusion chromatography (SEC) and provides guidelines for optimum support design. The chapter provides a survey of the current state-of-the-art with respect to the surface modification of silica for SEC packings in aqueous eluents. The properties of commercial packings and columns are listed and compared. An advice is also discussed on the operation and maintenance of columns with a view to achieving high resolution and long life-time. In SEC, solute elution is based on equilibrium, entropy-controlled size exclusion process. According to their size, the so…
The behavior of solutions of a parametric weighted (p, q)-laplacian equation
2021
<abstract><p>We study the behavior of solutions for the parametric equation</p> <p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ -\Delta_{p}^{a_1} u(z)-\Delta_{q}^{a_2} u(z) = \lambda |u(z)|^{q-2} u(z)+f(z,u(z)) \quad \mbox{in } \Omega,\, \lambda &gt;0, $\end{document} </tex-math></disp-formula></p> <p>under Dirichlet condition, where $ \Omega \subseteq \mathbb{R}^N $ is a bounded domain with a $ C^2 $-boundary $ \partial \Omega $, $ a_1, a_2 \in L^\infty(\Omega) $ with $ a_1(z), a_2(z) &gt; 0 $ for a.a. $ z \in \Omega $, $ p, q \in (1, \infty) $ and $ \Delta_{p}^{a_1}, \Delta_{q}^{a_2} $ are weighted …
Positive solutions of discrete boundary value problems with the (p,q)-Laplacian operator
2017
We consider a discrete Dirichlet boundary value problem of equations with the (p,q)-Laplacian operator in the principal part and prove the existence of at least two positive solutions. The assumptions on the reaction term ensure that the Euler-Lagrange functional, corresponding to the problem, satisfies an abstract two critical points result.
A singular (p,q)-equation with convection and a locally defined perturbation
2021
We consider a parametric Dirichlet problem driven by the (p,q)-Laplacian and a reaction which is gradient dependent (convection) and the competing effects of two more terms, one a parametric singular term and a locally defined perturbation. We show that for all small values of the parameter the problem has a positive smooth solution.
An existence result for a Neumann problem
2015
The main result of this paper deals with the existence of at least one positive solution for a second order Neumann boundary value problem. Such a result is obtained by using an abstract coincidence point theorem that allows to get our conclusion under non standard conditions on the nonlinearity.
Bifurcation phenomena for the positive solutions of semilinear elliptic problems with mixed boundary conditions
2016
We consider a parametric semilinear elliptic equation with a Cara-theodory reaction which exhibits competing nonlinearities. It is "concave" (sub-linear) near the origin and "convex" (superlinear) or linear near $+\infty$. Using variational methods based on the critical point theory, coupled with suitable truncation and comparison techniques, we prove a bifurcation-type theorem, describing the set of positive solutions as the parameter varies.