Search results for "ètica"

Prominence and centralization: a two-way contrast between lexical and epenthetic non-labial high vowels in Algherese Catalan

2015

Algherese Catalan has the peculiarity of presenting an inserted [i] vowel across words in order to avoid certain consonant codas. In this study, we compare five acoustic features of this epenthetic segment (i.e., duration, intensity, and the three first formants) with those of lexical /i/ vowels, both stressed and unstressed. The results indicate that the three vowels present differences only with respect to duration, F2 and, to a lesser extent, F3. The second formant values decline progressively from the lexical stressed vowels to the inserted unstressed segments, with lexical unstressed segments at an intermediate point. This gradation mirrors the relative prominence of each vowel. The di…

Una ética de la excelencia: Cayetana de la Cerda y la circulación de Madame de Lambert en España

2015

En este artículo se sintetizan las líneas maestras del pensamiento de Anne-Thérèse Marguenat, marquesa de Lambert (1647-1733) y se profundiza en el eco que su obra tuvo en España, aclarando algunos episodios poco conocidos y arrojando luz sobre el contexto en el que se realizó y publicó finalmente la versión castellana de sus ensayos y sobre la personalidad intelectual y circunstancias sociales de su traductora, Cayetana de la Cerda y Vera, condesa de Lalaing (1755-1798). Se pretende así analizar las prácticas de transferencia y mediación cultural, interrogándonos sobre los significados con que su pensamiento y su figura pudieron ser investidos por parte de los sujetos implicados en su lect…

Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond.

2022

Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear transcription and cytoplasmic mRNA stability. In recent years, it has been revealed that several RNA-binding proteins (RBPs) that perform functions in mRNA decay can move to the nucleus and regulate transcription. The RBPs involved in transcription can also travel to the cytoplasm and regulate mRNA degradation and/or translation. The multifaceted functions of these shuttling nucleo-cytoplasm RBPs have raised the possibility that they can act as mRNA metabolism coordinator…

Two Enhancers Control Transcription of Drosophila muscleblind in the Embryonic Somatic Musculature and in the Central Nervous System

2014

The phylogenetically conserved family of Muscleblind proteins are RNA-binding factors involved in a variety of gene expression processes including alternative splicing regulation, RNA stability and subcellular localization, and miRNA biogenesis, which typically contribute to cell-type specific differentiation. In humans, sequestration of Muscleblind-like proteins MBNL1 and MBNL2 has been implicated in degenerative disorders, particularly expansion diseases such as myotonic dystrophy type 1 and 2. Drosophila muscleblind was previously shown to be expressed in embryonic somatic and visceral muscle subtypes, and in the central nervous system, and to depend on Mef2 for transcriptional activatio…

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

2008

Inner nuclear membrane proteins containing a LEM (LAP2, emerin, and MAN1) domain participate in different processes, including chromatin organization, gene expression, and nuclear envelope biogenesis. In this study, we identify a robust genetic interaction between transcription export (TREX) factors and yeast Src1, an integral inner nuclear membrane protein that is homologous to vertebrate LEM2. DNA macroarray analysis revealed that the expression of the phosphate-regulated genes PHO11, PHO12, and PHO84 is up-regulated in src1Δ cells. Notably, these PHO genes are located in subtelomeric regions of chromatin and exhibit a perinuclear location in vivo. Src1 spans the nuclear membrane twice an…

The Saccharomyces cerevisiae Hot1p regulated gene YHR087W (HGI1) has a role in translation upon high glucose concentration stress.

2012

Abstract Background While growing in natural environments yeasts can be affected by osmotic stress provoked by high glucose concentrations. The response to this adverse condition requires the HOG pathway and involves transcriptional and posttranscriptional mechanisms initiated by the phosphorylation of this protein, its translocation to the nucleus and activation of transcription factors. One of the genes induced to respond to this injury is YHR087W. It encodes for a protein structurally similar to the N-terminal region of human SBDS whose expression is also induced under other forms of stress and whose deletion determines growth defects at high glucose concentrations. Results In this work …

Cabut/dTIEG associates with the transcription factor Yorkie for growth control

2015

The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth…

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Sign.: a-h8, i6, k4. - Data completa, 28 gener, 1499 L. gòt. - 2 mides. - 30 lín. - Inic. grav. - Tintes vermella i negra. - Filigr.: mà i estel

Saccharomyces cerevisiae signature genes for predicting nitrogen deficiency during alcoholic fermentation

2007

Genome-wide analysis of the wine yeast strain Saccharomyces cerevisiae PYCC4072 identified 36 genes highly expressed under conditions of low or absent nitrogen in comparison with a nitrogen-replete condition. Reverse transcription-PCR analysis for four of these transcripts with this strain and its validation with another wine yeast strain underlines the usefulness of these signature genes for predicting nitrogen deficiency and therefore the diagnosis of wine stuck/sluggish fermentations.

The molecular characterization of new types of Saccharomyces cerevisiae × S. kudriavzevii hybrid yeasts unveils a high genetic diversity.

2012

11 pages, 2 tables, 4 figures. --Article first published online: 6 JAN 2012. --This is the pre-peer reviewed version of the following article: Peris, D., Belloch, C., Lopandić, K., Álvarez-Pérez, J. M., Querol, A. and Barrio, E. (2012), The molecular characterization of new types of Saccharomyces cerevisiae × S. kudriavzevii hybrid yeasts unveils a high genetic diversity. Yeast, 29: 81–91. which has been published in final form at http://dx.doi.org/10.1002/yea.2891