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showing 10 items of 5782 documents
Radio frequency fingerprinting for outdoor user equipment localization
2017
The recent advancements in cellular mobile technology and smart phone usage have opened opportunities for researchers and commercial companies to develop ubiquitous low cost localization systems. Radio frequency (RF) fingerprinting is a popular positioning technique which uses radio signal strength (RSS) values from already existing infrastructures to provide satisfactory user positioning accuracy in indoor and densely built outdoor urban areas where Global Navigation Satellite System (GNSS) signal is poor and hard to reach. However a major requirement for the RF fingerprinting to maintain good localization accuracy is the collection and updating of large training database. The Minimization…
ARAB-NORMAN HERITAGE: STATE OF KNOWLEDGE AND NEW ACTIONS AND INNOVATIVE PROPOSAL
2017
Abstract. This paper wants to offers a perlustrative recognition on the 'state of the studies', concerning to the Arab-Norman architecture of Palermo, admissed by Unesco in 2015 and explain a research in progress which, starting from re-cognition of the peculiarities of the restoration work carried out on it, consisting of the identification of authentic material-constructive values and / or reconstruction, it orients itself to develop a concrete proposal of filing for a more conscious knowledge. She, moreover, wants contribute to real enhancement through the use of targeted communication strategies that use innovative means capable, on one hand, to attracting the greatest possible number o…
TLR7 controls VSV replication in CD169(+) SCS macrophages and associated viral neuroinvasion
2019
Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS neuroinvasion. To date, the precise mechanisms controlling VSV infection in SCS macrophages remain incompletely understood. Here, we show that Toll-like receptor-7 (TLR7), the main sensing receptor for VSV, is central in controlling lymph-borne VSV infection. Following VSV skin infection, TLR7−/− mice display significantly less VSV titers in the draining lymph nodes (dLN) and viral replication is attenuated in SCS macrophages. In contrast to effects o…
Innate Immune Cells' Contribution to Systemic Lupus Erythematosus
2019
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immun…
How the knowledge of interactions between meningococcus and the human immune system has been used to prepare effective Neisseria meningitidis vaccines
2015
In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity ofNeisseria meningitidisat a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). Here, we review the molecular biology of the infectious agent and, in particular, its interactions with the immune system, focusing on both the innate and the adaptive responses. Meningococci exploit different mechanisms and complex machineries in order to subvert the immune system and to avoid being killed. Capsular polysaccharide and lipooligosaccharide glycan composition, in…
De yngste barna og tingene deres – en ANT-analyse av lek i småbarnsavdelinger
2017
Artikkelen presenterer en mikro-etnografisk undersøkelse av barns forhold til tingene i to småbarnsavdelinger i norske barnehager. Hensikten er å forstå hvordan barns relasjoner til ting virker inn på deres mulighet til deltagelse og sosial posisjonering i gruppen. Undersøkelsen er basert på Aktør-Nettverk-Teori som vektlegger tingenes betydning som agens i sosiale nettverk og tingenes funksjon som forlengelse av barnas kropper. Undersøkelsen viser at tingene har betydning som legitim inngangsbillett til deltagelse i lekegrupper og at tingenes innbyrdes hierarkiske orden bidrar i å uttrykke den sosiale orden mellom barna som inngår i relasjon med dem. The article presents a micro-ethnograph…
Texts and Visuals in the Online Aesthetics of Migration: Translation as (Re)narration in the Creative Industries
2018
Texts and visuals in the online aesthetics of migration: Translation as (re)narration in the creative cultural industries Within the context of Computer-mediated communication discourse (Herring 1996; 2011, 2015), this study focuses on the investigation of Internet modalities and genres through which experiences of current migration are transferred from personal stories into online public narratives, also known as “transmedia storytelling” (Jenkins 2006; Jenkins, Ford, Green 2013). The art of telling migrant stories on the web produces acts of translation in terms of (re)statements of migrant lives. This mechanism owns a repository function, which is meant to spread narratives of migration …
Assessment of nonnegative matrix factorization algorithms for electroencephalography spectral analysis.
2020
AbstractBackgroundNonnegative matrix factorization (NMF) has been successfully used for electroencephalography (EEG) spectral analysis. Since NMF was proposed in the 1990s, many adaptive algorithms have been developed. However, the performance of their use in EEG data analysis has not been fully compared. Here, we provide a comparison of four NMF algorithms in terms of accuracy of estimation, stability (repeatability of the results) and time complexity of algorithms with simulated data. In the practical application of NMF algorithms, stability plays an important role, which was an emphasis in the comparison. A Hierarchical clustering algorithm was implemented to evaluate the stability of NM…
EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.
2015
KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in cell lines with different KRAS mutations. Cells harboring a single KRASG13D allele showed the most tumorigenic profile, with constitutive activation of the downstream pathway, rendering them EGF-unresponsive. Conversely, KRASA146T cells showed a full EGF-response in terms of signal transduction pathways, cell proliferation, migration or adhesion. Moreover, the global acetylome of CRC cells was al…
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli
2019
Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at other amino acid residues. A novel strategy employs a genetic code modification that allows incorporation of 3-nitrotyrosine (3-NT) during ribosomal protein synthesis to generate a recombinant protein with defined 3-NT-sites, in the absence of other post-translational modifications. This approach was applied to study the generation and stability of the 3-NT moiety in recombinant proteins produced in E.coli. Nitrated alpha-synuclein (ASYN) was…