Search results for "ANALOG"
showing 10 items of 677 documents
Simplification, not “tropicalization”, of temperate marine ecosystems under ocean warming and acidification
2021
Ocean warming is altering the biogeographical distribution of marine organisms. In the tropics, rising sea surface temperatures are restructuring coral reef communities with sensitive species being lost. At the biogeographical divide between temperate and tropical communities, warming is causing macroalgal forest loss and the spread of tropical corals, fishes and other species, termed “tropicalization”. A lack of field research into the combined effects of warming and ocean acidification means there is a gap in our ability to understand and plan for changes in coastal ecosystems. Here, we focus on the tropicalization trajectory of temperate marine ecosystems becoming coral-dominated systems…
The subtlety of sameness: a theory and computer model of analogy-making
1995
International audience; The research described in this book is based on the premise that human analogy-making is an extension of our constant background process of perceiving - in other words, that analogy-making and the perception of sameness are two sides of the same coin. At the heart of the author's theory and computer model of analogy-making is the idea that the building-up and the manipulation of representations are inseparable aspects of mental functioning, in contrast to traditional AI models of high-level cognitive processes, which have almost always depended on a clean separation. A computer program called Tabletop forms analogies in a microdomain consisting of everyday objects on…
Digital liquid-scintillation counting and effective pulse-shape discrimination with artificial neural networks
2014
Abstract A typical problem in low-level liquid scintillation (LS) counting is the identification of α particles in the presence of a high background of β and γ particles. Especially the occurrence of β-β and β-γ pile-ups may prevent the unambiguous identification of an α signal by commonly used analog electronics. In this case, pulse-shape discrimination (PSD) and pile-up rejection (PUR) units show an insufficient performance. This problem was also observed in own earlier experiments on the chemical behaviour of transactinide elements using the liquid-liquid extraction system SISAK in combination with LS counting. α-particle signals from the decay of the transactinides could not be unambigu…
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
2013
While acetylcholine (ACh) and muscarinic receptors in the bladder are mainly known for their role in the regulation of smooth muscle contractility, in other tissues they are involved in tissue remodelling and promote cell growth and proliferation. In the present study we have used primary cultures of human detrusor smooth muscle cells (HDSMCs), in order to investigate the role of muscarinic receptors in HDSMC proliferation. Samples were obtained as discarded tissue from men >65 years undergoing radical cystectomy for bladder cancer and cut in pieces that were either immediately frozen or placed in culture medium for the cell culture establishment. HDSMCs were isolated from samples, propagat…
Crenobalneotherapy (spa therapy) in patients with knee and generalized osteoarthritis: a post-hoc subgroup analysis of a large multicentre randomized…
2014
Abstract Objective To determine whether the addition of spa therapy to home exercises provides any benefit over exercises and the usual treatment alone in the management of generalised osteoarthritis associated with knee osteoarthritis. Methods This study was a post-hoc subgroup analysis of our randomised multicentre trial ( www.clinicaltrial.gov : NCT00348777 ). Participants who met the inclusion criteria of generalized osteoarthritis (Kellgren, American College of Rheumatology, or Dougados criteria) were extracted from the original randomised controlled trial. They had been randomised using Zelen randomisation. The treatment group received 18 days of spa treatment in addition to a home ex…
Les Lumières françaises du conventionnalisme à l'iconicité
2011
International audience; Au sein des Lumières françaises, l'arbitraire que Saussure qualifiera de "radical" (celui de la segmentation phonologique et sémantique) ne s'affirme qu'en tant que corollaire d'une théorie diamétralement opposée à celle de l'arbitraire classique ou aristotélicien (celui du rapport entre le son et le sens): cette théorie "analogique" et "imitative" constitue le véritable aboutissement de la recherche éclairée pour assurer l'origine naturelle de la parole et émanciper ainsi les sciences du langage de la perspective théologique. Une analyse du débat sur l'origine du langage entre Condillac (1746 et 1775), Rousseau (1755), Beauzée (1765) et De Brosses (1765) permet de l…
El debat sobre l'estructura causal de la teoria evolutiva: lleis, forces i analogies
2021
Resum: Aquest article analitza l’estructura de la teoria evolutiva i les discussions produides als seu voltant en les ultimes decades. En primer lloc, presente l’anomenada “interpretacio de forces” o “analogia newtoniana” i la seua estructura basada en l’elaboracio de tres lleis fonamentals. Mes endavant, mostre les critiques a aquesta interpretacio per diferents autors, en especial l’anomenada “versio estadistica” de la teoria evolutiva. Posteriorment, analitze la idoneitat de la interpretacio de forces i elabore una reformulacio de la mateixa que permet explicar el seu sorgiment i la seua utilitat dins de la literatura biologica. Abstract: This article analyses the structure of evolutiona…
Comparison of the crystal structures of 4,4′-bis[3-(4-methylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis[3-(2,2,6,6-tetramethylpiperidin…
2015
The crystal structures of the two title compounds display chair conformations of the piperidine rings in their molecules. In compound (I), the biphenyl system has a twisted conformation with a dihedral angle of 26.57 (6)° while in compound (II) the two phenyl rings are exactly coplanar.
Severe hypoglycemia is associated with antidiabetic oral treatment compared with insulin analogs in nursing home patients with type 2 diabetes and de…
2015
Abstract Objectives Severe hypoglycemia is associated with cognitive decline and dementia in older persons with type 2 diabetes. The role of antidiabetic treatments on severe hypoglycemia is unknown in dementia. The aims were to determine the prevalence of severe hypoglycemic events and investigate associations among severe hypoglycemic and specific antidiabetic treatments (classes of oral agents and types of insulin analogs) in a large sample of nursing home patients with diabetes according to dementia status. Design Cross-sectional observational study. Setting A total of 150 nursing homes across Italy. Participants A total of 2258 patients with type 2 diabetes (dementia = 1138, no dementi…
Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospe…
2019
Abstract Aims According to cardiovascular outcome trials, some sodium‐glucose contransporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real‐world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP‐1RA as second or a more advanced line of therapy. Materials and methods DARWIN‐T2D was a retrospective multi‐centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP‐1RA (exenatide once weekly or liraglutide). Data were c…