Search results for "ASIS"
showing 10 items of 4190 documents
Metaforisku terminu attīstība sengrieķu medicīnas tekstos
2021
Promocijas darbā “Metaforisku terminu attīstība sengrieķu medicīnas tekstos” ir veikta izpēte par metaforas lomu medicīnas terminoloģijas veidošanās sākumposmā. Teorētiskajā daļā izpētīta antīkās pasaules metaforas teorija, metaforas izpratne mūsdienās, attieksme pret metaforas lietojumu terminogrāfijā, kā arī medicīna antīkajā pasaulē. Empīriskā daļa veltīta terminu metaforizācijai un metaforisko terminu lietojumam, veicot statistikas analīzi hipokratiskajā un galēniskajā korpusā. Analizēta arī metaforiskās terminrades tradīcija osteoloģijā un angioloģijā – hipokratiskā korpusa traktātā “Par kaulu dabu” un galēniskā korpusa traktātā “Iesācējiem par kauliem”. Atslēgas vārdi: metafora, termi…
Nonstationary response envelope probability densities of nonlinear oscillators
2006
The nonstationary random response of a class of lightly damped nonlinear oscillators subjected to Gaussian white noise is considered. An approximate analytical method for determining the response envelope statistics is presented. Within the framework of stochastic averaging, the procedure relies on the Markovian modeling of the response envelope process through the definition of an equivalent linear system with response-dependent parameters. An approximate solution of the associated Fokker-Planck equation is derived by resorting to a Galerkin scheme. Specifically, the nonstationary probability density function of the response envelope is expressed as the sum of a time-dependent Rayleigh dis…
Simulation investigations of the position of Fatigue Fracture Plane in materials with biaxial loads
1989
In the paper three methods of determination of the expected fatigue fracture plane position under random triaxial stress state have been presented. They are: weight function method, variance method and damage cumulation method. The weight function method for biaxial cyclic loadings has been analysed with digital simulation. The fatigue fracture plane position has been determined with mean values of the direction cosines of principal stress axes. Averaging has been done at angle values with use of weights. Eleven various weights have been presented and their usability has been analysed on the basis of experimental results obtained by Rotvel, and Nishihara-Kawamoto. The weights with good agre…
An Open-Label Phase II Study Evaluating the Safety and Efficacy of Ramucirumab Combined With mFOLFOX-6 as First-Line Therapy for Metastatic Colorecta…
2014
Abstract Author Summary Background. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2) are believed to mediate angiogenesis in colorectal cancer (CRC). Ramucirumab (RAM; IMC-1121B) is a human IgG1 monoclonal antibody that inhibits VEGF ligand binding to VEGFR-2, inhibiting VEGFR-2 activation and signaling. Methods. Patients with metastatic CRC, Eastern Cooperative Oncology Group performance status 0–1, and adequate organ function who had not received chemotherapy for metastatic disease received RAM and the modified FOLFOX-6 regimen every 2 weeks. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety. The sample size wa…
Differential Effects of Biologics on Psoriasis-Related Vascular Inflammation and Risk of Thrombosis
2020
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad from Ministerio de Ciencia, Innovación y Universidades and European Regional Development Fund (Spain) [RTI2018-094436-B-I00]; Ministerio de Sanidad y Consumo CIBERehd (Spain) [CB06/04/0071]; Generalitat Valenciana (Spain) [PROMETEO/2018/141]; Proyectos Grupos Emergentes [GV/2019/043]; and Universidad Europea (Spain) (2018/UEM32 and 2019/UEM29]. 8.551 JCR (2020) Q1, 4/69 Dermatology 1.951 SJR (2020) Q1, 54/438 Biochemistry No data IDR 2020 UEV
A second strain gradient elasticity theory with second velocity gradient inertia – Part I: Constitutive equations and quasi-static behavior
2013
Abstract A multi-cell homogenization procedure with four geometrically different groups of cell elements (respectively for the bulk, the boundary surface, the edge lines and the corner points of a body) is envisioned, which is able not only to extract the effective constitutive properties of a material, but also to assess the “surface effects” produced by the boundary surface on the near bulk material. Applied to an unbounded material in combination with the thermodynamics energy balance principles, this procedure leads to an equivalent continuum constitutively characterized by (ordinary, double and triple) generalized stresses and momenta. Also, applying this procedure to a (finite) body s…
Donkey Fascioliasis Within a One Health Control Action: Transmission Capacity, Field Epidemiology, and Reservoir Role in a Human Hyperendemic Area.
2020
A One Health initiative has been implemented for fascioliasis control in a human hyperendemic area for the first time. The area selected for this multidisciplinary approach is the Northern Bolivian Altiplano, where the highest prevalences and intensities in humans have been reported. Within the strategic intervention axis of control activities concerning animal reservoirs, complete experimental studies, and field surveys have been performed to assess the fascioliasis transmission capacity and epidemiological role of the donkey for the first time. Laboratory studies with altiplanic donkey-infecting Fasciola hepatica and altiplanic Galba truncatula snail vector isolates demonstrate that the d…
Phenotypic analysis of adults of Fasciola hepatica, Fasciola gigantica and intermediate forms from the endemic region of Gilan, Iran.
2006
Fascioliasis is an important human and animal disease caused by Fasciola hepatica and Fasciola gigantica. In Iran, the distribution of these two species overlaps in most areas, including the northern human endemic province of Gilan where both fasciolids are simultaneously found in individual cattle and buffaloes. A phenotypic study of fasciolid adult flukes from naturally infected bovines from Gilan was carried out by means of an exhaustive morphometric analysis using traditional microscopic measurements and an allometric model. The Iranian fasciolids were compared to F. hepatica and F. gigantica standard populations, i.e. from geographical areas where both species do not co-exist (Bolivia …
MM3-ELISA evaluation of coproantigen release and serum antibody production in sheep experimentally infected with Fasciola hepatica and F. gigantica.
2008
During an experimental infection of sheep with Fasciola hepatica or F. gigantica, MM3-SERO and MM3-COPRO ELISA tests were applied to compare the kinetics of antibody production and coproantigen release between the 2nd and 32nd week post-infection (wpi). The Kato-Katz technique was used to measure the kinetics of egg shedding by both Fasciola species (eggs per gram of feces, epg). The kinetics of IgG antibodies for all sheep infected with F. hepatica and F. gigantica followed a similar pattern. Optical density (OD) increased rapidly between the 4th until the 12th wpi, when the highest values were reached and then decreased slowly until the 32nd wpi. Coproantigen levels increased above the cu…
Fasciola gigantica transmission in the zoonotic fascioliasis endemic lowlands of Guilan, Iran: experimental assessment.
2014
The lowland flatlands around the city of Bandar-Anzali, at the Caspian Sea shore, Guilan province, are an endemic area where Fasciola gigantica appears to be the fasciolid species involved and past outbreaks affecting around 15,000 people and the highest human infection rates in Iran have been reported. Fascioliasis transmission in that area has been experimentally analysed for the first time, by means of assays of monomiracidial (Group A: 120 snails) and pentamiracidial (Group B: 96 snails) infections of local Radix lymnaeid snails with a local cattle F. gigantica isolate. Ribosomal DNA ITS-2 sequencing proved that Lymnaea (Radix) gedrosiana should henceforth be considered a synonym of Rad…