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Sorption and mechanism studies of Cu2+, Sr2+ and Pb2+ ions on mesoporous aluminosilicates/zeolite composite sorbents

2020

The research aimed to develop a novel mesoporous aluminosilicate/zeolite composite by the template co-precipitation method. The effect of aluminosilicate (AlSi) and zeolite (NaY) on the basic properties and adsorption capacity of the resultant composite was conducted at different mass ratios of AlSi/NaY (i.e., 5/90, 10/80, 15/85, 20/80, and 50/50). The adsorption characteristics of such composite and its feedstock materials (i.e., aluminosilicates and zeolite) towards radioactive Sr2+ ions and toxic metals (Cu2+ and Pb2+ ions) in aqueous solutions was investigated. Results indicated that BET surface area (SBET), total pore volume (VTotal), and mesopore volume (VMeso) of prepared materials f…

Global Estimation of Biophysical Variables from Google Earth Engine Platform

2018

This paper proposes a processing chain for the derivation of global Leaf Area Index (LAI), Fraction of Absorbed Photosynthetically Active Radiation (FAPAR), Fraction Vegetation Cover (FVC), and Canopy water content (CWC) maps from 15-years of MODIS data exploiting the capabilities of the Google Earth Engine (GEE) cloud platform. The retrieval chain is based on a hybrid method inverting the PROSAIL radiative transfer model (RTM) with Random forests (RF) regression. A major feature of this work is the implementation of a retrieval chain exploiting the GEE capabilities using global and climate data records (CDR) of both MODIS surface reflectance and LAI/FAPAR datasets allowing the global estim…

Biological and Proteomic Characterization of the Anti-Cancer Potency of Aqueous Extracts from Cell-Free Coelomic Fluid of Arbacia lixula Sea Urchin i…

2022

Echinoderms are an acknowledged source of bioactive compounds exerting various beneficial effects on human health. Here, we examined the potential in vitro anti-hepatocarcinoma effects of aqueous extracts of the cell-free coelomic fluid obtained from the sea urchin Arbacia lixula using the HepG2 cell line as a model system. This was accomplished by employing a combination of colorimetric, microscopic and flow cytometric assays to determine cell viability, cell cycle distribution, the possible onset of apoptosis, the accumulation rate of acidic vesicular organelles, mitochondrial polarization, cell redox state and cell locomotory ability. The obtained data show that exposed HepG2 cells under…

Stress ossidativo e disfunzione endoteliale

2011

Oxidative and nitrosative stress in the metastatic microenvironment.

2010

Metastases that are resistant to conventional therapies are the main cause of most cancer-related deaths in humans. Tumor cell heterogeneity, which associates with genomic and phenotypic instability, represents a major problem for cancer therapy. Additional factors, such as the attack of immune cells or organ-specific microenvironments, also influence metastatic cell behavior and the response to therapy. Interaction of cancer and endothelial cells in capillary beds, involving mechanical contact and transient adhesion, is a critical step in the initiation of metastasis. This interaction initiates a cascade of activation pathways that involves cytokines, growth factors, bioactive lipids and r…

Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?

2020

Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …

Cryptogein signaling in tobacco: in search for nitric oxide targets

2013

Nitric oxide (NO) triggers various physiological responses in plants. Notably, NO is recognized to account for the response to biotic stresses. We previously reported that NO is produced in tobacco cells exposed to cryptogein, a 10 kDa elicitor secreted by the oomycete Phytophthora cryptogea. To decipher the role of NO, we identified and characterized S-nitrosylated proteins in tobacco cell suspensions elicited by cryptogein. Several candidates were identified including the chaperone-like AAA+ATPase CDC48 and a calmodulin isoform (CaM). Interestingly, the Cys residue undergoing S-nitrosylation in CaM is located in the first Ca2+ binding EF hand and is not or poorly conserved in other organi…

The Anti-Cancer Effect of

2019

Ethanolic extracts from Mangifera indica L. have been proved to possess anti-tumor properties in many cancer systems. However, although most effects have been demonstrated with fruit pulp extract, the underlying molecular mechanisms of mango peel are still unclear. This study was designed to explore the effects of mango peel extract (MPE) on colon cancer cell lines. MPE affected cell viability and inhibited the colony formation trend of tumor cells, while no effects were observed in human dermal fibroblasts used as a non-cancerous cell line model. These events were a consequence of the induction of apoptosis associated to reactive oxygen species (ROS) production, activation of players of th…

Reactive Compatibilization of PBT/EVA Blends with an Ethylene-Acrylic Acid Copolymer and a Low Molar Mass Bis-Oxazoline

2004

Polyesters and polyolefins form highly incompatible blends with poor properties and gross morphology that hinder any practical applications. In this work, the possibility to compatibilize an incompatible blend of poly(butylene terephthalate) (PBT) with ethylene vinyl acetate (EVA) by adding a bis-oxazoline compound, 2,2'-(1,3-phenylene)-bis(2-oxazoline) (PBO), and an ethylene acrylic acid copolymer (EAA) as compatibilizer precursors has been studied. The results indicate that the binary uncompatibilized blends show poor mechanical properties and a bad morphology with scarce adhesion between the phases. The situation is only slightly improved when the EAA is added while the best performance …

On the modification of the nitrile groups of acrylonitrile/butadiene/styrene into oxazoline in the melt

2000

Oxazoline functionality is well known to be highly reactive toward a lot of other functional groups like carboxyls, hydroxyls, mercaptans, and amines. In this work we report the possibility to modify the nitrile groups of an acrylonitrile/butadiene/styrene (ABS) copolymer into oxazoline in the molten state in the presence of aminoethanol as modifier agent and zinc acetate as a catalyst. The reaction has been carried out in a batch mixer and in a corotating twin screw extruder. The conversion of the nitrile groups into oxazoline has been verified by infrared spectroscopy, NMR analysis microanalysis and confirmed by thermomechanical characterization. The results indicate that the kinetic of g…