Search results for "Azine"
showing 10 items of 1589 documents
A New Pt(II) Complex with Anionic s-Triazine Based NNO-Donor Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis and DFT Studies
2022
The reaction of PtCl2 with s-triazine-type ligand (HTriaz) (1:1) in acetone under heating afforded a new [Pt(Triaz)Cl] complex. Single-crystal X-ray diffraction analysis showed that the ligand (HTriaz) is an NNO tridentate chelate via two N-atoms from the s-triazine and hydrazone moieties and one oxygen from the deprotonated phenolic OH. The coordination environment of the Pt(II) is completed by one Cl−1 ion trans to the Pt-N(hydrazone). Hirshfeld surface analysis showed that the most dominant interactions are the H···H, H···C and O···H intermolecular contacts. These interactions contributed by 60.9, 11.2 and 8.3% from the…
La revista Cuadernos de Ágora y sus relaciones con Latinoamérica
2014
Cuadernos de Agora (1956-1964) was a post-war magazine directed by the poet Concha Lagos. His short story (nearly eight years) was characterized by the independent and participatory spirit, also tended bridges to other magazines outside the Spanish territory, both in Europe and in Latin America. This text present one summary of poetic relationship between Spain and Latin America from the perspective of Cuadernos de Agora.
Amphoteric, prevailingly cationic L-arginine polymers of poly(amidoamino acid) structure: Synthesis, acid/base properties and preliminary cytocompati…
2013
A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N′-methylenebisacrylamide. Chain-extension of acrylamide end-capped L-ARGO7 oligomers with piperazine leads to high-molecular-weight copolymers in which L-arginine maintains its absolute configuration. Acid/base properties of L-ARGO7 polymers show isolectric points of ≈10 and positive net average charges per repeating unit at pH = 7.4 from 0.25 to 0.40. These arginine-rich synthetic polymers possibly share some of the unique biological properties of polyarginine cell-permeating peptides. In vitro tests with mouse embryo fibroblasts balb/3T3 clone A31 show that L-ARGO7 polymers a…
Titanium and Vanadium Catalysts with 2-Hydroxyphenyloxazoline and Oxazine Ligands for Ethylene-Norbornene (co)Polymerization
2019
A series of titanium and vanadium complexes with oxazoline 2-(4,5-dihydro-1,3-oxazol-2-yl)phenol (L1), 2-(4-methyl-4,5-dihydro-1,3-oxazol-2-yl)phenol (L2), and oxazine 2-(5,6-dihydro-4H-1,3-oxazin-2-yl)phenol (L3) ligands were synthesized, and their structures were determined by NMR and MS methods as (L)2MtCl2. The vanadium complexes were found to be highly active in ethylene (7300 kgPE/(molV·
Trans -Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging
2020
Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed a polymer-based targeting agent that can be used for pretargeted imaging and thus separates tumor accumulation from the imaging step in time. The developed targeting agent is based on polypeptide-graft-polypeptoid polymers (PeptoBrushes) functionalized with trans-cyclooctene (TCO). The complementary In-111-labeled imaging agent is a 1,2,4,5-tetrazine derivative, which can react with aforementioned TCO-modified PeptoBrushes i…
„Społeczeństwo Otwarte” – czasopismo wspierające nauczycieli w wychowaniu uczniów do demokracji i obywatelskości
2019
W artykule przedstawiono zarys działalności redakcji czasopisma „Społeczeństwo Otwarte”, wydawanego w latach 1990-1998. Jedynego w owym czasie w kraju, starającego się zagospodarować ten obszar znaczeń, który w polskiej szkole i edukacji realizowanej przez nauczycieli należało łączyć z demokracją, formacją obywatela i nauką o społeczeństwie. Na podstawie przeprowadzonej analizy miesięcznika przybliżono wybrane treści wiążące się z problematyką wychowania obywatelskiego, demokracją, ładem społecznym i samorządnością. Były publikowane przez redakcję w celu wspierania nauczycieli w samokształceniu i uzupełnianiu kompetencji, koniecznych w edukacji uczniów do życia w społeczeństwie demokratyczn…
Development of herbicide-resistant varieties of foxtail millet
2012
International audience; Developing herbicide resistance in forsaken small crops could be a way to maintain food and cultivation system diversity, otherwise they would disappear due to the impossibility or cost to control the weeds. It is the case with foxtail millet, Setaria italica, a small grain, preferentially autogamous, C4 cereal. Three different herbicide-resistant materials were developed using wild germplasm resources. They allowed: 1) to better characterize the resistance mechanisms and inheritance; 2) provide plant materials to test the efficiency of the crop resistance at field level; and 3) experiment on the possible flow back of the resistance gene to the wild relative and amon…
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…
2016
A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…
Testing the effectiveness of pyrazine defences against spiders
2020
Insects live in a dangerous world and may fall prey to a wide variety of predators, encompassing multiple taxa. As a result, selection may favour defences that are effective against multiple predator types, or target-specific defences that can reduce predation risk from particular groups of predators. Given the variation in sensory systems and hunting tactics, in particular between vertebrate and invertebrate predators, it is not always clear whether defences, such as chemical defences, that are effective against one group will be so against another. Despite this, the majority of research to date has focused on the role of a single predator species when considering the evolution of defended…
Molecular and supramolecular structures of self-assembled Cu(II) and Co(II) complexes with 4,4’-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4-…
2020
The molecular and supramolecular structures of [Cu(PTM)Cl2]*0.75MeOH (1), [Co(PTM)Cl2]; (2A) and [Co(PTM)Cl2(EtOH)]; (2B) complexes, where PTM is 4,4’-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4-diyl]dimorpholine, were presented. In complexes 1 and 2A, the Cu(II) and Co(II) are tetra-coordinated with a distorted tetrahedral coordination environment. In case of complex 2B, an additional ethanol molecule is found coordinated with Co(II) leading to a highly distorted penta-coordinated Co(II) complex. In all cases, the PTM ligand is acting as a bidentate NN-chelate. Hirshfeld surface analysis indicated the importance of H⋯H (49.0–55.1%), Cl⋯H (18.8–20.5%) and O⋯H (8.3–9.9%) contacts in…