Search results for "BEM"
showing 10 items of 133 documents
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Analisi strutturale condotta con il BEM simmetrico in analogia al FEM
2009
Nell’articolo si presenta l’approccio agli spostamenti del Metodo Simmetrico degli Elementi di Contorno attraverso una suddivisione del corpo continuo in macroelementi denominati ebem. Attraverso questo approccio, caratterizzato da una forte condensazione delle variabili, si determina per ogni e-bem una matrice capostipite a partire dalla quale viene generata la relazione costitutiva del singolo e-bem. Quest’ultima relaziona soltanto variabili all’interfaccia tra i macroelementi, e precisamente il vettore delle trazioni pesate con il vettore degli spostamenti nodali e con il vettore delle azioni esterne. Una tale strategia è molto simile a quella seguita dal Metodo degli Elementi Finiti, ma…
SHAKEDOWN ANALYSIS BY BEM
2000
In the ambit of the symmetric Galerkin boundary element formulation the statical shakedown load multiplier and the limit analysis are reformulated making use of macrozone modelling. The subdivision of the domain into macroelements makes it possible to deal with piecewise homogeneous materials of the body. For each macroelement a discretization of the boundary and a subdivision of the domain into portions called cells are performed in order to introduce the unknowns (i.e. traction and displacement discontinuities) on the boundary and material plastic laws appropriately interpolated. The weighed regularity imposed between adjacent macroelements produces algebraic operators which are symmetric…
FORMULAZIONE SIMMETRICA DEL BEM NELL' ANALISI ELASTICA DI SISTEMI LASTRE- PIASTRE
2011
Studi su Bembo e Della Casa
2006
Gli scritti che costituiscono il volume, Studi su Bembo e Della Casa, sono, nella loro quasi totalità, un’indagine sulla profonda lezione che dal maestro veneziano venne al più illustre dei suoi discepoli. Da tali studi emerge che l’originalità indiscussa del Casa, poeta e prosatore, in volgare e in latino, poggia su un solido fondamento bembiano, sia sul piano critico-retorico, sia su quello di una più complessiva esemplarità letteraria.
Słowo Boże w liturgii eucharystycznej Kościołów syryjskich
2017
In all liturgical families, including the Syriac ones, the proclamation of the Word of God is an essential element of liturgical celebration. Although in the numerous communities sharing the same tradition of Antioch, Edessa and Nisibis the practice of reading from the Bible during the liturgy looks different there are some common elements. They include: a great respect for the Bible (the book seen as a monstrance), the readings taking place during the Liturgy of Catechumens; the division of readings from both the Old and New Testament into the psalmodic chants, the practice of reading the Gospel which is reserved strictly for the priest, the presence of the biblical poetry during the whole…
Treatment of Advanced Hormone Receptor-Positive (HR+) HER2-negative Breast Cancer
2019
AbstractThe article gives an overview of current treatment options for metastatic hormone receptor-positive and HER2-negative breast cancer. The focus is on combined therapies, e.g., with CDK4/6 inhibition compared with purely endocrine-based therapies in the pre- and postmenopause, presenting the latest study results. The addition of a CDK4/6 inhibitor to endocrine-based therapy with an aromatase inhibitor or fulvestrant leads to a marked improvement in progression-free survival and is independently beneficial whether palbociclib, ribociclib or abemaciclib is involved. The particular clinical status of inhibition of cyclin-dependent kinases argues for its use in the first-line treatment of…
An extended version of CVBEM method for solving shear problems
2011
Computational Homogenization of Heterogeneous Materials by a Novel Hybrid Numerical Scheme
2020
The Virtual Element Method (VEM) is a recent numerical technique capable of dealing with very general polygonal and polyhedral mesh elements, including irregular or non-convex ones. Because of this feature, the VEM ensures noticeable simplification in the data preparation stage of the analysis, especially for problems whose analysis domain features complex geometries, as in the case of computational micro-mechanics problems. The Boundary Element Method (BEM) is a well known, extensively used and effective numerical technique for the solution of several classes of problems in science and engineering. Due to its underlying formulation, the BEM allows reducing the dimensionality of the proble…
A fast BEM for the analysis of damaged structures with bonded piezoelectric sensors
2010
A fast boundary element method for the analysis of three-dimensional solids with cracks and adhesively bonded piezoelectric patches, used as strain sensors, is presented. The piezoelectric sensors, as well as the adhesive layer, are modeled using a 3D state-space finite element approach. The piezoelectric patch model is formulated taking into account the full electro-mechanical coupling and embodying the suitable boundary conditions and it is eventually expressed in terms of the interface variables, to allow a straightforward coupling with the underlying host structure, which is modeled through a 3D dual boundary element method, for accurate analysis of cracks. The technique is computationa…