Search results for "BIOMARKER"

The matrix metalloproteinase and insulin-like growth factor system in oral cancer : a prospective clinical study

2017

Aim The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters. Results Serum levels of MMP-3 were significantly higher in OSCC patients compared to healthy subjects (p=0.004). Mean IGF-1 and IGFBP-3 levels in OSCC patients were sign…

Inflammatory response elements, glycan, and proteome profiles as salivary biomarkers for the early diagnosis of OSCC

2021

El cáncer oral, sobre todo el, carcinoma oral de células escamosas (COCE), es la neoplasia maligna más común en la cavidad oral que se caracteriza por un mal pronóstico y una baja tasa de supervivencia, cuando se diagnostica en estadios avanzados. Puede ser tratado de forma efectiva si se detecta en estadios iniciales, mejorando el pronóstico. Por tanto, tras la prevención, el diagnóstico precoz se ha convertido en el principal objetivo en el manejo del cáncer oral, dado su impacto positivo en la supervivencia y calidad de vida de estos pacientes. A menudo, los escasos síntomas iniciales pasan desapercibidos y la enfermedad se descubre en fases avanzadas, por lo que se requiere mejorar el d…

The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study

2017

Eik Schiegnitz,1 Peer W Kämmerer,2 Holger Schön,1 Christoph Gülle,1 Manfred Berres,3,4 Keyvan Sagheb,1 Bilal Al-Nawas5 1Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, 2Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre Rostock, Rostock, 3Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, 4Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Mainz, 5Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Martin-Luther University Ha…

Effects of training background to acute psychological stress biomarkers

2016

Stressi on laajalti tutkittu aihe ja kroonisen stressin aiheuttamat terveysvaikutukset ovat merkittäviä maailmassa. Stressi käsitteenä voidaan ajatella tarkoittavan tilannetta, jolloin homeostaasia järkytetään. Stressi voidaan jakaa henkiseen ja fyysiseen sekä pitkäaikaiseen ja lyhytkestoiseen. Ihmisen kokiessa stressiä, niin henkistä tai fyysistä, tapahtuu hermoston toiminnan johdosta erilaisia fysiologisia muutoksia ihmiskehossa. Reaktio stressiin johtaa esimerkiksi sykkeen kiihtymiseen, verenpaineen kohoamiseen sekä erilaisten hormonien erittymiseen, kuten: adrenaliini ja kortisoli. Tässä tutkimuksessa on tarkoituksena tutkia miten erilaisen harjoitustaustan omaavien henkilöiden fysiolog…

Changes in Body Composition, Energy Metabolites and Electrolytes During Winter Survival Training in Male Soldiers

2022

The aim of this study was to examine changes in body composition, energy metabolites and electrolytes during a 10-day winter survival training period. Two groups of male soldiers were examined: the REC group (n = 26; age 19.7 ± 1.2 years; BMI 23.9 ± 2.7) had recovery period between days 6 and 8 in the survival training, whereas the EXC group (n = 42; age 19.6 ± 0.8 years; BMI 23.1 ± 2.8) did not. The following data were collected: body composition (bioimpedance), energy balance (food diaries, heart rate variability measurements), and biomarkers (blood samples). In survival training, estimated energy balance was highly negative: −4,323 ± 1,515 kcal/d (EXC) and −4,635 ± 1,742 kcal/d (REC). Be…

The challenges of GxE research: A rejoinder

2017

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

An Overview on the Use of miRNAs as Possible Forensic Biomarkers for the Diagnosis of Traumatic Brain Injury

2023

Determining the cause of death is one of the main goals of forensic pathology. However, conditions can occur in which common approaches—external inspection, autopsy, histology, etc.—might not be conclusive. With the advancement of molecular biology, several investigative techniques have been developed over the years, and the application as approaches complementary to routine procedures has proved useful in these cases. In this context, microRNA (miRNA) profiling has attracted increasing interest due to these molecules’ ability to regulate physiological and pathological processes. The evidence of differential miRNA expression in both animal models and human samples of traumatic brain injury …

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial

2022

Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…

Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs

2014

Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…