Search results for "Bell"

Peñón de la Zorra y Puntal de los Carniceros (Villena, Alicante): Revisión de dos conjuntos de yacimientos campaniformes en el corredor del Vinalopó

2002

En el presente artículo se revisa la información existente sobre dos yacimientos campaniformes del Alto Vinalopó –Peñón de la Zorra y Puntal de los Carniceros–. Su importancia dentro de la investigación en tierras levantinas los ha convertido en una referencia casi obligatoria desde su publicación por parte de J. M. Soler García. In this article is cheked information about two bell beaker sites from Vinalopo Valley –Peñón de la Zorra and Puntal de los Carniceros–. The importance of this archaeological sites of investigation concerning Levante areas have got that these places would be an obligatory reference since the publication by J.M. Soler Garcia.

L'ANTICO CAMPANILE DELLA CATTEDRALE DI LECCE IN UN CONSULTO DEL 1574

2016

L'antico campanile della cattedrale di Lecce si trovava in una posizione diversa rispetto a quello esistente costruito nel 1658. La maestosa torre, con cinque ordini e una terminazione a corona, era collocata di fianco all'antica facciata principale della chiesa, sul lato sinistro. Nel 1574 a causa di numerosi crolli, gli amministratori della chiesa decisero di avvalersi del parere tecnico di tre professionisti: Padoano Schiero, Padoano Baxi e Gabriele Meschinello, chiamati ad esprimersi in merito alla pericolosità di tali crolli e allo stato della torre. Vennero prodotte tre relazioni tecniche i cui contenuti illustravano la necessità di demolire la torre al fine di scongiurare eventuali d…

Un’architettura in divenire: il campanile maggiore della cattedrale di Palermo (XIV-XIX secolo)

2018

Luogo della permanenza, ma talora anche di mutamenti repentini, agevolati tra l’altro dalla vulnerabilità intrinseca alle strutture turriformi, o ancora di stratificazioni che tengono insieme la memoria del tempo pregresso e l’adesione a linguaggi e tecniche di attualità , il campanile riverbera in molti casi cambiamenti e discontinuità nella cultura architettonica dominante in un preciso contesto urbano, in momenti diversi della sua storia , assumendo talora anche valenze mutevoli nel corso del tempo. Di ciò offre un esempio eloquente il campanile maggiore della cattedrale di Palermo. Permanenza e ricostruzione sono i termini, apparentemente antitetici, che sintetizzano una travagliata vic…

Heroes of Middle-Earth : J. Campbell's monomyth in J. R. R. Tolkien's The Lord of the Rings (1954-1955)

2007

Genomic portrait of a sporadic amyotrophic lateral sclerosis case in a large spinocerebellar ataxia type 1 family

2020

Background: Repeat expansions in the spinocerebellar ataxia type 1 (SCA1) gene ATXN1 increases the risk for amyotrophic lateral sclerosis (ALS), supporting a relationship between these disorders. We recently reported the co-existence, in a large SCA1 family, of a clinically definite ALS individual bearing an intermediate ATXN1 expansion and SCA1 patients with a full expansion, some of which manifested signs of lower motor neuron involvement. Methods: In this study, we employed a systems biology approach that integrated multiple genomic analyses of the ALS patient and some SCA1 family members. Results: Our analysis identified common and distinctive candidate genes/variants and related biolog…

Radiation-induced vascular changes in the intracranial irradiation field in medulloblastoma survivors: An MRI study

2019

While survival times after treatment of medulloblastoma are increasing, little is known about radiochemotherapy (RCT)-induced cerebrovascular changes. High resolution vessel wall imaging (VWI) sequences are an emerging tool for the evaluation of cerebrovascular diseases. We performed VWI in medulloblastoma long-term survivors to screen for late sequelae of RCT.Twenty-two pediatric medulloblastoma survivors (mean age 25.8 years (10-53 years); 16.3 years (mean) post primary RCT (range 1-45 years)) underwent 2D VWI-MRI. Vessel wall thickening, contrast enhancement and luminal narrowing were analyzed. The findings were correlated with the patients' radiation protocols.Vessel wall changes were o…

Cartelization process in institutionalized environments: legitimation and political communication

2017

International audience; The main objective of this paper is to analyze cartel party tendencies toward professionalization of communicative institutional processes (Mair, 015).The main role of the media in a audience democracy is indisputable (Manin, 1998). So the media politics are one of the main features of public space. In this way, Political parties have become platforms of placement of their leaders to occupy the largest number of institutional positions. Consequently, this phenomenon has spread as a common practice of our political system. The emergence of partisan elite, which has professionalized itself in high political-institutional positions, has colonized the leadership of publi…

Central and Peripheral Secondary Cell Death Processes after Transient Global Ischemia in Nonhuman Primate Cerebellum and Heart

2019

Cerebral ischemia and its pathological sequelae are responsible for severe neurological deficits generally attributed to the neural death within the infarcted tissue and adjacent regions. Distal brain regions, and even peripheral organs, may be subject to more subtle consequences of the primary ischemic event which can initiate parallel disease processes and promote comorbid symptomology. In order to characterize the susceptibility of cerebellar brain regions and the heart to transient global ischemia (TGI) in nonhuman primates (NHP), brain and heart tissues were harvested 6 months post-TGI injury. Immunostaining analysis with unbiased stereology revealed significant cell death in lobule II…

Electron microscopic demonstration of intracelluar promethazine accumulation sites by a precipitation technique: application to the cerebellar cortex…

1996

A method is described that allows electron microscopic identification of the phenothiazine neuroleptic promethazine after supravital intracardiac injection of high drug concentrations (greater than or equal to 3 %). The cerebellar cortex of the mouse was used for the investigation. This procedure is based on simultaneous fixation of drug and tissue by immersion in a paraformaldehyde-glutaraldehyde solution with the addition of phosphomolybdic acid. The electron microscopic investigation revealed that the drug could easily be identified as an electron-dense precipitate. Subpopulations of neurons exhibited a higher affinity for the drug than others, but no preference for any nerve cell type …

Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma

2016

We aimed to identify new cell-membrane antigens implicated in opsoclonus-myoclonus with neuroblastoma. The sera of 3 out of 14 patients showed IgG electron-microscopy immunogold reactivity on SH-SY5Y neuroblastoma cells. Immunoprecipitation experiments using rat brain synaptosomes and SH-SY5Y cells led to the identification of: (1) thirty-one nuclear/cytoplasmic proteins (including antigens HuB, HuC); (2) seven neuronal membrane proteins, including the Shaw-potassium channel Kv3.3 (KCNC3), whose genetic disruption in mice causes ataxia and generalized muscle twitching. Although cell-based assays did not demonstrate direct antigenicity, our findings point to Shaw-related subfamily of the pot…