Search results for "CARDIOVASCULAR DISEASE"

Detección de factores de riesgo cardiovascular en pacientes con psicosis

2011

Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study

2016

Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers. Here I used an ecologic regression study to test the hypothesis that Rhesus factor polymorphism is stabilized by heterozygote advantage. The study was performed in 65 countries for which the frequencies of RhD phenotypes and specific disease burden data were available. I performed multiple multivariate covariance analysis with five potential confounding variables: GDP, latitude (distance from the equator), humidity, medical care expenditure per capita and frequencies of smokers…

Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders

2020

The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and small humanin-like peptides (SHLPs). Humanin inhibits mitochondrial complex 1 activity and limits the level of oxidative stress in the cell. Data show that mitochondrial-derived peptides have a role in improving metabolic diseases, such as type 2 diabetes. Perhaps humanin can be used as a marker f…

Leukocyte Redistribution: Effects of Beta Blockers in Patients with Chronic Heart Failure

2009

BACKGROUND:Overproduction of pro-inflammatory cytokines is a well established factor in the progression of chronic heart failure (CHF). Changes in cellular immunity have not been widely studied, and the impact of standard medication is uncertain. Here we investigate whether a leukocyte redistribution occurs in CHF and whether this effect is influenced by beta-blocker therapy. METHODOLOGY:We prospectively studied 75 patients with systolic CHF (age: 68+/-11 years, left ventricular ejection fraction 32+/-11%, New York Heart Association class 2.5+/-0.7) and 20 age-matched healthy control subjects (age: 63+/-10 years). We measured the response of cells to endotoxin exposure in vitro, analysed su…

[Diagnostic performance of surface electrocardiogram in early detection of chagasic cardiomyopathy].

2013

Contrast-enhanced cardiac magnetic resonance imaging (CMR) allows early detection of myocardial involvement by Trypanosoma cruzi infection. The aim of our study was to assess the diagnostic performance of the surface electrocardiogram (ECG) in the early detection of Chagas' cardiomyopathy (CCM) compared with CMR.We included 43 asymptomatic patients (30 women, 42 ± 9.8 years), diagnosed of Chagas disease. The sample was divided into 2 groups according to the presence (n=17) or absence (n=26) of electrocardiographic abnormalities. All patients underwent CMR and late gadolinium enhancement (LGE) was used as a marker of early myocardial involvement.Six (14%) patients had a LGE significantly hig…

Physical inactivity and cardiovascular disease at the time of coronavirus disease 2019 (COVID-19).

2020

Ischemic cardiovascular disease in workers occupationally exposed to urban air pollution – A systematic review

2018

Introduction Cardiovascular disease is the first cause of morbidity and mortality worldwide. Among several known risk factors, researchers also focus their attention on the chronic exposure to air pollution. There is much evidence that exposure to air pollution, especially to ultrafine particles, can damage the endothelium and can favour cardiovascular diseases in the general population. Occupational exposition could be an additive risk factor for the cardiovascular system. This article presents a scientific review of the linkage between occupational exposure to air pollution and ischemic heart disease. Material and methods A scientific review was undertaken, followed by PRISMA Statements. …

Noninvasive evaluation of the celiac trunk and superior mesenteric artery with multislice CT in patients with chronic mesenteric ischaemia.

2008

This study sought to assess the role of multislice computed tomography (MSCT) in patients with suspected chronic mesenteric ischaemia (CMI). Forty-five patients (29 men; mean age 68) underwent MSCT angiography of the abdomen for suspected CMI (main clinical finding: postprandial abdominal pain). The scan protocol was detectors/collimation 16/0.75 mm; feed 36 mm/s; rotation time 500 ms; increment 0.4 mm; 120-150 mAs and 120 kVp. A volume of 80 ml of contrast material was administered through an antecubital vein (rate 4 ml/s), followed by 40 ml of saline (rate 4 ml/s). Images were analysed on the workstation with different algorithms (axial image scrolling, multiplanar reconstructions, maximu…

Selection of blood pressure signal for baroreflex analysis

2020

This study aims to evaluate the strength of the causal coupling among systolic, mean and diastolic blood pressure (SBP, MBP and DBP) with heart period (RR interval) (evaluating cardiac chronotropic baroreflex arm) and peripheral vascular resistance (PVR) (evaluating vascular resistance baroreflex arm) in frequency domain using partial spectral decomposition method. We recorded beat-to-beat RR, SBP, MBP and DBP and PVR values in 39 volunteers during supine rest and head-up tilt. Our results showed that during supine rest the most dominant causal coupling was from DBP to RR in both low and high frequency bands and significantly decreased during orthostasis. The strength of spectral couplings …

Strenuous exercise and the heart: are we not seeing the wood for the trees?

2014

The health benefits of regular moderate-intensity physical activity (e.g. brisk walking, jogging) are well established and include, among others, a lower risk of all-cause mortality and cardiovascular disease (CVD). Yet whether such benefits, especially with regard to CVD, are also conferred by higher exercise levels is a matter of growing controversy in the medical literature. For instance, Guash and Mont recently expressed understandable concern about the link between regular strenuous endurance exercise. 4.036 JCR (2014) Q1, 29/123 Cardiac and cardiovascular systems UEM