Search results for "CCR"
showing 10 items of 574 documents
Expert‑panel accreditation evaluation‑practices: an autoethnographic case study of the Community of Madrid
2017
Accreditation is defined by the European Higher Education Area quality‑assurance agencies as a key element in quality management and continuous improvement in university teaching‑learning processes, and is an institutional practice that started to be developed in 2014 in Spain. This article illustrates the case of the Community of Madrid Quality Agency, as case study analysis through my experience as a panel member for the accreditation of higher‑education qualifications. Methodologically, it is based on an autoethnographic approach and uses the theory of symbolic interactionism to reveal and analyse the evaluative process and culture. For this purpose, two analytical axes were drawn: stude…
X-ray emitting MHD accretion shocks in classical T Tauri stars. Case for moderate to high plasma-beta values
2009
AIMS. We investigate the stability and dynamics of accretion shocks in CTTSs, considering the case of beta >= 1 in the post-shock region. In these cases the 1D approximation is not valid and a multi-dimensional MHD approach is necessary. METHODS. We model an accretion stream propagating through the atmosphere of a CTTS and impacting onto its chromosphere, by performing 2D axisymmetric MHD simulations. The model takes into account the stellar magnetic field, the gravity, the radiative cooling, and the thermal conduction (including the effects of heat flux saturation). RESULTS. The dynamics and stability of the accretion shock strongly depends on the plasma beta. In the case of shocks with…
Jet collimation in NGC 315 and other nearby AGN
2020
Aims. The collimation of relativistic jets in galaxies is a poorly understood process. Detailed radio studies of the jet collimation region have been performed so far in few individual objects, providing important constraints for jet formation models. However, the extent of the collimation zone as well as the nature of the external medium possibly confining the jet are still debated. Methods. In this article we present a multi-frequency and multi-scale analysis of the radio galaxy NGC 315, including the use of mm-VLBI data up to 86 GHz, aimed at revealing the evolution of the jet collimation profile. We then consider results from the literature to compare the jet expansion profile in a samp…
Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.
2014
Abstract In vivo studies questioned the ability of Langerhans cells (LCs) to mediate CD8+ T cell priming. To address this issue, we used intradermal immunization with plasmid DNA, a system in which activation of CD8+ T cells depends on delayed kinetics of Ag presentation. We found that dendritic cells (DCs) located in the skin at the time of immunization have limited ability to activate CD8+ T cells. This activity was mediated by a second generation of DCs that differentiated in the skin several days after immunization, as well as by lymph node–resident DCs. Intriguingly, CD8+ T cell responses were not affected following treatment with clodronate liposomes, immunization of CCR2−/− mice, or …
Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity: Results of Studies Performed in a Sicilian Population
2006
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic ba…
Amazing IL-9: revealing a new function for an “old” cytokine
2012
Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with…
Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance
2012
Background Allergic contact dermatitis is one of the most common occupational diseases. A main protective mechanism in those who do not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of contact allergen, which is termed low zone tolerance (LZT). The mechanisms that determine the tolerance induction in subjects with LZT are still elusive. Objective We performed analysis of the role of CD4 + CD25 + forkhead box protein 3 (FOXP3)–positive regulatory T (Treg) cells and dendritic cells (DCs) in mice with LZT. Methods Mechanisms of tolerance induction were analyzed in a murine model of LZT by using FOXP3 and IL-10 reporter mice, as well as mice that a…
Educació per al desenvolupament sostenible: una via per a l’enfortiment de la responsabilitat social universitària
2018
Antecedents: s’analitzen els antecedents del concepte de Responsabilitat Social Universitària (RSU), les arrels de la qual es troben en l’evolució del concepte de Responsabilitat Social Empresarial (RSE), en què es destaca la idea central que l’empresa del segle xxi ha d’aportar a la societat alguna cosa més que la producció de béns, serveis i guanys financers, per la qual cosa es bolca l’interès cap a la creació de valors socials, sobre la base d’actuacions i procediments ètics globals. Mètode: es fa una recerca documental de tres conceptes clau, RSU, Educació per al Desenvolupament Sostenible (EDS) i acreditació universitària per a l’enfortiment d’ambdós conceptes.Resultats: es proposa un…
Vesiculated tuffs and associated features
1974
Vesiculated tuffs are tuffs that contain vesicles between the ash particles. Formation of the vesicles is the result of trapping of steam, the transporting agent of volcanic base surges, in wet, muddy or sticky ash deposited by the base surges. Vesiculated tuffs are described from various maars and tuff-rings in Europe (Iceland, France, Germany) and USA together with associated surface features such as: gravity flowage ripples, mud flow channels, current ripples, and current ridges. Other features described are: plastering of ash against obstacles and vesiculated accretionary lapilli, the latter containing vesicles in the outer layer. Vesiculated base surge deposits probably contained as mu…
Disaster management in hospitals
1998
A disaster situation for a hospital occurs when the need for medical treatment overwhelms the actual hospital treatment capacity. 1 This may be defined by numerical or situational means; the threshold must always be the result of an individual assessment of the given health care unit. A disaster situation may also be defined as the point of no return to normal standard operating procedures in a certain hospital. In case of a disaster, health care units are required to have and activate a disaster management plan (DMP). In the USA the requirements of the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO) are trend-setting; in European countries, regulations are normall…