Search results for "Cain"

“Much Ado About Something: Nineteenth-Century American Writers and the Atlantic Cable”

2022

Cet article décrit et analyse les réactions de plusieurs grands auteurs américains (Thoreau, Longfellow, Irving, Melville, Whittier, Whitman et Emerson) au succès en 1858 du premier lien télégraphique transatlantique entre les États-Unis et l’Europe. Ces réponses à cet exploit technologique apparaissaient dans des journaux privés, des lettres, des éditoriaux et des notes marginales; elles étaient parfois incorporées dans des œuvres littéraires. Dans presque tous les cas, les réactions peuvent...

Modulation by oxotremorine and atropine of acetylcholine release evoked by electrical stimulation of the myenteric plexus of the guinea-pig ileum

1977

1. The effects of oxotremorine and atropine on the release of acetylcholine from longitudinal muscle strips of the guinea-pig ileum stimulated at frequencies between 0.1 and 3 Hz in the presence of eserine were investigated. In control experiments the acetylcholine output per stimulus declined with increasing frequencies of stimulation. 2. Oxotremorine inhibited the release of acetylcholine in a concentration-dependent fashion. At a concentration of 10−6 M oxotremorine, the release evoked by 0.1 Hz was reduced by 54%. With increasing frequencies of stimulation the inhibitory effect of oxotremorine became smaller. 3. Atropine enhanced the output of acetylcholine evoked by electrical stimulat…

Cholinesterase activity and exposure time to acetylcholine as factors influencing the muscarinic inhibition of [3H]-noradrenaline overflow from guine…

1985

Guinea-pig isolated atria were incubated and loaded with [3H]-noradrenaline. The release of 3H and of [3H]-noradrenaline was induced by field stimulation (6-9 trains of 150 pulses at 5 Hz). The stimulation-evoked overflows of 3H and of [3H]-noradrenaline were determined. In the absence of an inhibitor of acetylcholinesterase, acetylcholine (12 min preincubation before nerve stimulation, up to 10 microM) failed to inhibit the evoked [3H]-noradrenaline overflow. In the presence of atropine, an increase by acetylcholine of evoked release was observed in the same atria. In contrast, the selective muscarinic agonist methacholine significantly decreased the evoked overflow. The inhibition was ant…

Tensions and expression in Milos Forman’s American films

2012

Milos Forman’s American films require a plural outlook. The director has always been drawn to stories of conflicts that are essential, according to him, to study human passion. This tension, thematic as well as esthetic, allows him to show the smallest mechanisms that lead to oppression in European and American stories, providing the viewer with a lesson of anatomy that pinpoints the most invisible magnetic forces leading to power. This course is accompanied by a journey to individualism, through forces involved in the identification with attractive though realistic characters, through the rediscovery of individual freedom within primitive or regressive worlds, insisting on the necessity of…

Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and…

1999

In an effort to learn more about the general structure-activity relationships of cocaine with the aim to elucidate those structural features that might confer antagonistic properties to such analogues, we describe herein our synthetic efforts to prepare two-carbon bridge functionalized (methoxylated and hydroxylated) analogues. Our approach makes use of a modification of the classical Willstatter synthesis of cocaine: Mannich type cyclization of acetonedicarboxylic acid monomethyl ester with methylamine hydrochloride and 2-methoxysuccindialdehyde in a citrate buffer solution afforded the 6- and 7-substituted 2-carbomethoxy-3-tropinones 3a,b and 4a,b in approximate yields of 64%. Reduction o…

Prenatal cocaine exposure alters spontaneous and cocaine-induced motor and social behaviors.

2005

The abuse of cocaine in pregnant women could affect emotional behaviors in their descendents. The aim of this work was to evaluate the effects of prenatal cocaine exposure on spontaneous and cocaine-induced motor and social behaviors in mice. Three kinds of prenatal treatment were used: non-treated animals; mice treated daily with physiological saline during the last week of pregnancy; and finally, those treated with cocaine (25 mg/kg) during the same period. Behavioral studies took place on adult males, which were housed in two different conditions: grouped (non-aggressive), or isolated (aggressive). Cocaine-pretreated animals exhibited slight differences in spontaneous motor activity, but…

Autopsia de un body packer al que le habían extraído la droga siendo cadáver

2015

Existen multitud de métodos empleados por los narcotraficantes para el traslado internacional de la droga, siendo el más peligroso para el individuo el transporte en el interior de su organismo, el denominado “body packer”. En ocasiones, alguno de los paquetes puede romperse y provocar la muerte por la salida masiva del tóxico. El hallazgo del envoltorio roto y el resto de paquetes íntegros, con la droga en su interior, al realizar la autopsia, son muy importantes para el diagnóstico. En el caso que nos ocupa, la previa manipulación del cadáver para extracción y recuperación de la droga, ha dificultado la determinación de la causa de la muerte. There are many methods used by drug trafficker…

202C.S.E. analgesia in active labor: effects of the intrathecal administration of l-Bupivacaine or Ropivacaine on onset and side effects

2006

Determination of bupivacaine in human plasma by high-performance liquid chromatography.

1984

Interpleurale Katheteranalgesie

1994

Interpleural analgesia is a method of postoperative analgesia that was developed by Kvalheim and Reiestad in 1984. The main indication is postoperative pain after unilateral thoracic and upper abdominal surgery. Many authors report good analgesic effects and better postoperative lung function following cholecystectomy. There is some controversy on the effectiveness of this method after thoracic surgery. Further indications are post-traumatic pain after multiple rib fractures and chronic pain in the upper abdomen (carcinoma of the pancreas, chronic pancreatitis). The local anaesthetic of choice is bupivacaine (in concentrations of 0.25-0.75%, injection volumes of 10-40 ml, with or without ep…