Search results for "Clero"

Associazione tra pattern dietetici, insulino-resistenza ed arteriosclerosi carotidea silente in un campione di adulti apparentemente sani

2014

Predictors for Therapy Response to Intrathecal Corticosteroid Therapy in Multiple Sclerosis

2019

\(\bf Objective:\) The autoimmune disease Multiple Sclerosis (MS) represents a heterogeneous disease pattern with an individual course that may lead to permanent disability. In addition to immuno-modulating therapies patients benefit from symptomatic approaches like intrathecal corticosteroid therapy (ICT), which is frequently applied in a growing number of centers in Germany. ICT reduces spasticity, which elongates patient's walking distance and speed, thus improves quality of life. \(\bf Methods:\) In our study we set out to investigate cerebrospinal fluid (CSF) parameters and clinical predictors for response to ICT. Therefore, we analyzed 811 CSF samples collected from 354 patients over …

Low HDL-cholesterol concentrations cause atherosclerotic disease to develop

2009

La presenza di disfunzione endoteliale e di aterosclerosi carotidea sono forti predittori di eventi clinici in pazienti asintomatici.

2007

Chronic cerebrospinal venous insufficiency: state of the art and research challenges

2012

This review discusses a potential vascular basis for multiple sclerosis (MS). The idea that MS could be related to vascular disease is not new, with the first reports describing connections between veins and MS plaques dating from the 19th century. The venous abnormalities found in MS patients, the socalled chronic cerebrospinal venous insufficiency, are currently interpreted as congenital venous malformations. Catheter venography is regarded as the gold standard to assess these lesions, while other tests, such as Doppler sonography and magnetic resonance venography, are much less accurate. Importantly, a relationship between venous pathologies and MS has not yet been proven, especially reg…

Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies.

2022

IntroductionCardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases.Material and methodsThe recruitment was carried out by 438 primary care physicians in Poland. The…

ASSOCIAZIONE TRA ATEROSCLEROSI CAROTIDEA E MALATTIA CORONARICA: ECO-COLORDOPPLER DEI TRONCHI SOVRAORTICI E CORONAROGRAFIA A CONFRONTO IN PAZIENTI CON…

2012

Cardiovascular diseases and HCV infection: a simple association or more?

2013

HCV infection, metabolic disorders and cardiovascular alterations, considered alone or in combination, are common conditions in a large proportion of the general population. Consequently, determining whether the association of HCV infection with cardiometabolic disorders is simply coincidental or, conversely, caused by pathogenetic mechanisms (in)directly linking chronic HCV infection to these disorders, would be of extreme relevance. Several clinical studies have shown that metabolic disorders—namely, type 2 diabetes,1 insulin resistance (IR)2 and hepatic steatosis3—are highly prevalent in patients with chronic hepatitis C (CHC) compared with non-infected patients. Experimental and clinica…

SAT0390 Microrna Expression Profile in Fibromyalgia Patients: A Pilot Matched Case Control Study

2013

Background Fibromyalgia (FM) is a clinical syndrome characterized by musculoskeletal pain and tenderness. Diagnosis is mainly based on exclusion of other resembling diseases since validated biological tests are still lacking. Identification of disease-related markers will enable clinicians to effectively diagnose FM, follow the progress of the disease, monitor the effects of therapeutic approaches and probably develop preventive programs. MicroRNAs (miRNAs) are pieces of 18-25 nucleotides capable of regulating gene expression. Changes in their expression levels have been linked to environmental responses as well as to pathological processes. Their recent association to some other chronic di…

Is season of birth associated with multiple sclerosis?

2000

Objective - To compare the monthly distribution of multiple sclerosis (MS) patients' births with that of the Sicilian population. Background -Studies on the association between season of birth and risk of MS are scanty and controversial. Design and methods - Archives of the Institute of Neuropsychiatry of the Universities of Palermo and Catania were searched up to 1995 for definite MS patients (McDonald & Halliday criteria). The monthly distribution of MS patients' births (N=965) was compared with that of the Sicilian population (N = 5,608,307). Results -The distribution of births among MS patients compared with the general population was not different when tested by the X 2 statistic (P > …