Search results for "Coronaviru"
showing 10 items of 1289 documents
Rationale and evidence on the use of tocilizumab in COVID-19: A systematic review. Authors’ reply
2021
Igualdad y no discriminación en tiempo de pandemia
2021
[ES] El presente trabajo realiza un análisis de cuál ha sido el impacto que el SARS-Cov-2 ha tenido en diversos grupos sociales, desde el prisma de la confrontación de los determinantes sociales y legales de la salud. En el texto se argumenta la visión crítica que se debe afrontar frente a la utilización de los últimos por suponer la invisibilización de patrones subordiscriminatorios dentro del contexto social actual. [EN] This article analyses the impact that SARS-Cov-2 has had on various social groups, by confronting of the social and legal determinants of health. The text argues that a critical view that must be hold in the use of the latter, as it disregards subordinate patterns of disc…
Adoption of digital innovations in rural enterprises during COVID-19
2021
The COVID-19 pandemic has rapidly affected the operating conditions of enterprises. Traditional customers and operational models are changing radically in the short term. Digitalisation and digital methods provide an opportunity to re-organise working methods and create a new kind of business to replace old methods and business models. Compared to urban enterprises, rural enterprises have less experience with digital tools and are less likely to adopt digital innovations. This makes rural enterprises especially vulnerable. The purpose of this study is to provide insights into how micro-enterprises and small and medium-sized enterprises in rural areas have addressed the COVID-19 pandemic, th…
Wpływ epidemii koronawirusa na medialne transmisje Eucharystii
2021
The coronavirus epidemic has become a completely unexpected challenge for the pastoral activity of the Church. The introduced restrictions on the number of the faithful who can participate in the parish liturgy and in some countries even the complete closure of places of worship, resulted in a new perception of the role of media broadcasts of the Eucharist. The article presents the history of introducing television broadcasts of the Holy Mass and the related and variously solved problem of the place where such a liturgy is celebrated. Issues related to the specific phenomenon of broadcasting the Holy Mass from parish churches via the Internet with the use of one webcam are also discussed. A…
Stay at Home and Teach: A Comparative Study of Psychosocial Risks Between Spain and Mexico During the Pandemic
2020
Context The emergency situation caused by coronavirus disease 2019 (COVID-19) has affected different facets of society. Although much of the attention is focused on the health sector, other sectors such as education have also experienced profound transformations and impacts. This sector is usually highly affected by psychosocial risks, and this could be aggravated during the current health emergency. Psychosocial risks may cause health problems, lack of motivation, and a decrease of effectiveness at work, which in turn affect the quality of teaching. Despite their importance, there are hardly any studies that analyze psychosocial risks of non-university teachers during a health emergency su…
Performance Comparison of a Flow Cytometry-based and Two Commercial Chemiluminescent Immunoassays for Detection and Quantification of Antibodies Bind…
2021
ABSTRACTThe performance of a laboratory-developed quantitative IgG/IgA flow cytometry-based immunoassay (FCI) using Jurkat T cells stably expressing full-length native S protein was compared against Elecsys® electrochemiluminiscent (ECLIA) Anti-SARS-CoV-2 S (Roche Diagnostics, Pleasanton, CA, USA), and LIAISON® SARS-CoV-2 TrimericS IgG chemiluminiscent assay (CLIA) (Diasorin S.p.a, Saluggia, IT) for detection and quantitation of SARS-CoV-2-specific antibodies. A total of 225 serum/plasma specimens from 120 acute or convalescent COVID-19 individuals were included. Overall, IgG/IgA-FCI yielded the highest number of positives (n=179), followed by IgA-FCI (n=177), Roche ECLIA (n=175), IgG-FCI (…
Drugs Repurposing for Coronavirus Treatment: Computational Study Based On Molecular Topology
2020
The present communication illustrates the results of a computational study based on molecular topology, focused on the repositioning of drugs to treat the SARS-CoV-2 virus, better known as coronavirus, responsible for the COVID-19 disease. Using lopinavir, a well-known viral protease inhibitor as the reference drug, a mathematical pattern is found allowing the screening of the market drugs, searching for potential candidates to inhibit the said enzyme. This way new possible therapeutic alternatives to fight the coronavirus are found. Results indicate that antivirals such as brecanavir, as well as various groups of drugs, among which are antibiotics of the macrolide family (azithromycin, cla…
Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Exp…
2021
The global pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening the health and economic systems worldwide. Despite the enormous efforts of scientists and clinicians around the world, there is still no drug or vaccine available worldwide for the treatment and prevention of the infection. A rapid strategy for the identification of new treatments is based on repurposing existing clinically approved drugs that show antiviral activity against SARS-CoV-2 infection. In this study, after developing a quantitative structure activity relationship analysis based on molecular topology, several macrolide antibiotics are identified as promising SARS-…
Severe asthma at COVID-19 time: what is new on biologic therapies.
2021
COVID-19 Vaccination Willingness and Hesitancy in Patients With Inflammatory Bowel Diseases: Analysis of Determinants in a National Survey of the Ita…
2021
The coronavirus disease 2019 (COVID-19) pandemic has not finished yet, and the most promising option towards its ending is widespread vaccination. Because patients with inflammatory bowel diseases (IBDs), namely Crohn’s disease (CD) and ulcerative colitis (UC), often require immune-modifying treatment, which might increase the risk of opportunistic infection,1 their vaccination history for several infectious diseases is routinely checked, and when inadequate, vaccination is performed at diagnosis or ideally before immune suppressive treatment is started.1 However, IBD patients were not found to be at an increased risk of developing COVID-19 or of experiencing a more severe disease course.2