Search results for "Coronavirus disease"

showing 10 items of 961 documents

SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Management of anaphylaxis due to COVID-19 vaccines in the elderly

2021

Submitted by (omml@ubi.pt) on 2021-07-05T10:47:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T10:49:11Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Rejected by Pessoa (pfep@ubi.pt), reason: Rever os nomes dos autores. Depois da correção é só voltar a submeter. on 2021-07-05T10:54:19Z (GMT) Submitted by (omml@ubi.pt) on 2021-07-05T11:52:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffab…

MaleAllergyPediatricsEaaci Position PaperCOVID-19 vaccinesolder (adultsGUIDELINES0302 clinical medicine[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesMedicine and Health SciencesImmunology and AllergyMedicine030212 general & internal medicineComputingMilieux_MISCELLANEOUSGeriatricsMESH: AgedRISKVaccines[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasespeople)EPINEPHRINEEpinephrine[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCOVID -19 vaccinesAnaphylaxismedicine.drugolder (adults/people)medicine.medical_specialtyCoronavirus disease 2019 (COVID-19)MESH: Covid-19MESH: EpinephrineImmunologyadrenaline; anaphylaxis; COVID-19 vaccines; older (adults/people); Aged; COVID-19 Vaccines; Epinephrine; Humans; Male; SARS-CoV-2; Anaphylaxis; COVID-19Settore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciences[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemDiabetes mellitusAnaphylaxis/etiologyanaphylaxisHumansMESH: SARS-CoV-2[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologyCOVID‐19 vaccinesOlder - Adults/peopleAsthmaAgedMESH: Humansadrenalinebusiness.industrySARS-CoV-2adrenaline anaphylaxis COVID-19 vaccines older (adults/people)COVID-19medicine.diseaseObesity[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyMESH: MaleMESH: AnaphylaxisOlder3121 General medicine internal medicine and other clinical medicinebusinessMESH: Covid-19 vaccines030215 immunologyAllergy
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Impact of the COVID-19 Outbreak on the Behavior of Families in Italy: A Focus on Children and Adolescents

2021

The COVID-19 pandemic has changed individuals' lifestyles to a great extent, particularly in Italy. Although many concerns about it have been highlighted, its impact on children and adolescents has scarcely been examined. The purpose of this study was to explore behavioral consequences and coping strategies related to the pandemic among families in Italy, by focusing on developmental ages from the caregivers' perspective, 3 weeks into quarantine. An exploratory cross-sectional online survey was conducted over 14 days. Google Forms was employed to conduct the survey. Demographic variables and pre-existing Psychological Weaknesses (PsW) were asked. Adults' sleep difficulties (SleepScore) and …

MaleCoping (psychology)Child Behaviorlaw.inventionstress0302 clinical medicinelawPandemicCOVID–19Medicine030212 general & internal medicineChildbehavioral changesOriginal Researchmedia_commonlcsh:Public aspects of medicinepsychological weaknessescopingMental HealthItalyChild PreschoolFemalePublic HealthAdultSleep Wake DisorderscaregiversAdolescentCoronavirus disease 2019 (COVID-19)Substance-Related Disordersmedia_common.quotation_subject03 medical and health sciencesAge groupsQuarantineHumansFamilysleepAgedbusiness.industrypandemicPublic Health Environmental and Occupational HealthCOVID-19Outbreaklcsh:RA1-1270COVID–19; behavioral changes; caregivers; coping; pandemic; psychological weaknesses; sleep; stress.Health SurveysMental healthAdolescent BehaviorbusinessWelfare030217 neurology & neurosurgeryDemography
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Statins and other drugs: Facing COVID-19 as a vascular disease

2020

Angiotensin-converting enzyme inhibitors (ACEi), angiotensin II receptor blockers (ARBs), and HMG-CoA reductase inhibitors ("statins") have been hypothesized to affect COVID-19 severity. However, up to now, no studies investigating this association have been conducted in the most vulnerable and affected population groups (ie, older adults residing in nursing homes). The objective of this study was to explore the association of ACEi/ARB and/or statins with clinical manifestations in COVID-19-infected older adults residing in nursing homes.We undertook a retrospective multicenter cohort study to analyze the association between ACEi/ARB and/or statin use with clinical outcome of COVID-19. The …

MaleCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralAngiotensin-Converting Enzyme InhibitorsRisk AssessmentSeverity of Illness IndexCohort StudiesBetacoronavirusAngiotensin Receptor AntagonistsBelgiumStatins Drugs COVID-19 Vascular DiseaseCause of DeathVascular DiseasePandemicOdds RatioHomes for the AgedHumansMedicineVascular DiseasesLetter to the EditorGeriatric AssessmentPandemicsAgedRetrospective StudiesAged 80 and overPharmacologybiologySARS-CoV-2business.industryVascular diseaseStatinsDrugsCOVID-19medicine.diseasebiology.organism_classificationVirologyNursing HomesSurvival RatePneumoniaLogistic ModelsTreatment OutcomeFemaleHydroxymethylglutaryl-CoA Reductase InhibitorsCoronavirus InfectionsbusinessNursing homesCoronavirus InfectionsBetacoronavirusPharmacological Research
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A Cross-Country Examination on the Fear of COVID-19 and the Sense of Loneliness during the First Wave of COVID-19 Outbreak

2021

The aim of the current study is to examine gender, age. and cross-country differences in fear of COVID-19 and sense of loneliness during the lockdown, by comparing people from those countries with a high rate of infections and deaths (e.g., Spain and Italy) and from countries with a mild spread of infection (e.g., Croatia, Serbia, Slovakia, Slovenia, and Bosnia and Herzegovina). A total of 3876 participants (63% female) completed an online survey on “Everyday life practices in COVID-19 time” in April 2020, including measures of fear of COVID-19 and loneliness. Males and females of all age groups in countries suffering from the powerful impact of the COVID-19 pandemic reported greater fear o…

MaleCross-country Fear of COVID-19 Loneliness Psychosocial distress COVID-19Health Toxicology and MutagenesisSloveniapandemijecoronaviruslcsh:MedicineDisease Outbreaksrestrictions0302 clinical medicineEconomic costPandemicstrah030212 general & internal medicineEveryday lifeukrepipublic healthLonelinessFearItalypsihosocialne stiskefearFemalemedicine.symptomPsychologySerbiaisolationmedicine.medical_specialtySlovakiaCoronavirus disease 2019 (COVID-19)Croatiafear of COVID-19Article03 medical and health sciencesmedicinelonelinessHumansPandemicsAgedBosnia and Herzegovinaudc:616-036.21:614:616.89-008.441osamljenostSARS-CoV-2koronavirusPublic healthpandemicjavno zdravjelcsh:RPublic Health Environmental and Occupational HealthOutbreakCOVID-19psychosocial distressMental healthSpainCommunicable Disease Controlcross-country030217 neurology & neurosurgeryDemographyizolacijaInternational Journal of Environmental Research and Public Health
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Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department…

2021

Background and importance A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED) and are diagnosed with COVID-19. Objective We investigated the incidence, risk factors, clinical characteristics and outcomes of DVT in patients with COVID-19 attending the ED before hospitalization. Methods We retrospectively reviewed all COVID patients diagnosed with DVT in 62 Spanish EDs (20% of Spanish EDs, case group) during the first 2 months of the COVID-19 outbreak. We compared DVT-COVI…

MaleDeep veinComorbidity030204 cardiovascular system & hematologyChest pain0302 clinical medicineRisk Factorsrisk factorsclinical characteristicsIncidenceIncidence (epidemiology)Age FactorsVenous ThromboembolismMiddle AgedPulmonary embolismVenous thrombosismedicine.anatomical_structureEmergency MedicineoutcomeFemalemedicine.symptomEmergency Service Hospitalsevere acute respiratory syndrome coronavirus 2Adultmedicine.medical_specialtyRisk Assessment03 medical and health sciencescoronavirus disease 2019Internal medicineThromboembolismmedicineHumanscardiovascular diseasesTromboembolismeAgedRetrospective Studiesdeep venous thrombosisbusiness.industryCOVID-19030208 emergency & critical care medicineRetrospective cohort studyOriginal ArticlesEmergency departmentOdds ratiomedicine.diseaseSpainCase-Control StudiesincidencePulmonary Embolismbusiness
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French organization for the pharmacovigilance of COVID-19 vaccines: A major challenge.

2021

International audience; In this special issue, we present the main highlights of the first weeks of pharmacovigilance monitoring of coronavirus disease 2019 (COVID-19) vaccines in this unprecedented situation in France: the deployment of a vaccination during an epidemic period with the aim of vaccinating the entire population and the intense pharmacovigilance and surveillance of these vaccines still under conditional marketing authorizations. In this unprecedented situation, the cross approach and interaction between the French pharmacovigilance network and French National Agency for the Safety of Medicines and Health Products (ANSM) has been optimized to provide a real-time safety related …

MaleEuropean levelCOVID-19 VaccinesCoronavirus disease 2019 (COVID-19)Adverse drug reactions030226 pharmacology & pharmacyArticleADR adverse drug reaction03 medical and health sciencesPharmacovigilance0302 clinical medicinePharmacovigilancePandemicMedicineAdverse Drug Reaction Reporting SystemsHumansPharmacology (medical)Drug reactionPEG polyethylene glycolEntire populationVaccinesbusiness.industrySOC system organ classSARS-CoV-2COVID coronavirus disease[SCCO.NEUR]Cognitive science/Neuroscience[SCCO.NEUR] Cognitive science/NeuroscienceAuthorizationCOVID-19Middle Agedmedicine.diseaseRPVC Regional Pharmacovigilance CenterVaccinationEMA European Medicines AgencyFemaleMedical emergencyFrancebusinessANSM Agence nationale de sécurité du médicament et des produits de santé (French National Agency for the Safety of Medicines and Health Products)OrganizationTherapie
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Use of the Barthel Index to Assess Activities of Daily Living before and after SARS-COVID 19 Infection of Institutionalized Nursing Home Patients

2021

The objective of the present study was to evaluate the activities of daily living (ADLs) using the Barthel Index before and after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and also to determine whether or not the results varied according to gender. The ADLs of 68 cohabiting geriatric patients, 34 men and 34 women, in two nursing homes were measured before and after SARS-CoV-2 (Coronavirus 2019 (COVID-19)) infection. COVID-19 infection was found to affect the performance of ADLs in institutionalized elderly in nursing homes, especially in the more elderly subjects, regardless of sex. The COVID-19 pandemic, in addition to having claimed many victims, espe…

MaleGerontologyActivities of daily livingCoronavirus disease 2019 (COVID-19)Barthel indexHealth Toxicology and MutagenesisSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Medicina Física y RehabilitaciónDiseaseÍndice Barthel030204 cardiovascular system & hematologyAffect (psychology)Persones gransArticleActivities of daily liveActividades cotidianas03 medical and health sciences0302 clinical medicineQuality of lifePandemicActivities of Daily LivingHumansBarthel indexMedicine030212 general & internal medicinePandemicsAgedSARS-CoV-2business.industryallergologyPublic Health Environmental and Occupational HealthRCOVID-19humanitiesVirusNursing HomesQuality of LifeMedicineEnfermeríaFemalebusinessNursing homeshuman activities
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Mental health and well-being during COVID-19 lockdown: A survey case report of high-level male and female players of an Italian Serie A football club

2021

Objectives: To describe high-level footballers’ levels and changes in mental health and well-being throughout a 8-week period of lockdown and restricted training during the COVID-19 pandemic. Method: One-hundred and one players belonging to four teams (women's and men's, first and U19 teams) of the same Italian Serie A club participated in the study. Data were collected through an online questionnaire, and administered at 2, 3, 5, 7 and 9 weeks after the start of the lockdown. Well-being, positive and negative affects measurements were examined. Results: Across the five measures, 36% of players reported clinical levels in depressive symptoms (scores ≤50) on at least one occasion. Thirteen p…

MaleGerontologyCoronavirus disease 2019 (COVID-19)SARS-CoV-2FootballCOVID-19Physical Therapy Sports Therapy and Rehabilitationpsychological health and well-beingMental healthFootball clubMental HealthSurveys and QuestionnairesTourism Leisure and Hospitality ManagementCommunicable Disease ControlWell-beingelite athletesHumansFemaleOrthopedics and Sports MedicineElite athletessense organsPsychologyPandemicsCovid-19 lockdownPeriod (music)Science and Medicine in Football
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The immediate impact of lockdown measures on mental health and couples’ relationships during the COVID-19 pandemic

2021

BackgroundLockdown measures during the COVID-19 pandemic are expected to have negative effects on mental health and relationship quality. However, little is known about the magnitude of these psychological effects on a population level and for vulnerable subgroups.MethodsA representative sample (N = 2503; 50.2% female; mean age = 49.5) of the German population was assessed face-to-face during the COVID-19 pandemic (February 10-April 25, 2020). They were examined for differences in mental health (BSI-18) and relationship quality (PFB) in a pre-lockdown and lockdown subsamples. After testing and establishing the measurement models in confirmatory factor analyses, we added covariates as predic…

MaleHealth (social science)Younger ageCoronavirus disease 2019 (COVID-19)03 medical and health sciences0302 clinical medicineRisk groupsHistory and Philosophy of ScienceGermanyPandemicHumans030212 general & internal medicinePandemicsRelationship qualityPopulation survey030505 public healthPandemicSARS-CoV-2COVID-19Regression analysisMiddle AgedMental healthCommunicable Disease ControlHousehold incomeCoronaFemaleMental health0305 other medical sciencePsychologyDemographySocial Science & Medicine
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