Search results for "Cut"

Correlation Between Smoking Paradox and Heart Rhythm Outcomes in Patients With Coronary Artery Disease Receiving Percutaneous Coronary Intervention

2022

BackgroundThe effect of smoking on short-term outcomes among patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) is controversial. However, little is known about the impact of smoking on long-term outcomes in patients with stable coronary artery disease (CAD) who receive PCI.MethodsA total of 2,044 patients with stable CAD undergoing PCI were evaluated. They were divided into two groups according to smoking status (current smokers vs. non-smokers). Baseline characteristics, exposed risk factors, angiographic findings, and interventional strategies were assessed to compare the long-term clinical outcomes between groups. Predictors for myocardial in…

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

2015

Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …

Longitudinal Stability of Reading Difficulties : Examining the Effects of Measurement Error, Cut-Offs, and Buffer Zones in Identification

2020

This study examined the stability of reading difficulties (RD) from grades 2 to 6 and focused on the effects of measurement error and cut-off selection in the identification of RD and its stability with the use of simulations. It addressed methodological limitations of prior studies by (a) applying a model-based simulation analysis to examine the effects of measurement error and cut-offs in the identification of RD, (b) analyzing a non-English and larger sample, and (c) examining RD in both reading fluency and reading comprehension. Reading fluency and reading comprehension of 1,432 Finnish-speaking children were assessed in grades 2 and 6. In addition to the use of single cut-off points on…

Noninvasive Ventilation in Critically Ill Patients

2015

Since its first application in the late 1980s, noninvasive ventilation (NIV) has been the first-line intervention for certain forms of acute respiratory failure. NIV may be delivered through the patient's mouth, nose, or both using noninvasive intermittent positive pressure ventilation or continuous positive airway pressure. When applied appropriately, NIV may reduce morbidity and mortality and may avert iatrogenic complications and infections associated with invasive mechanical ventilation. This article provides physicians and respiratory therapists with a comprehensive, practical guideline for using NIV in critical care. © 2015 Elsevier Inc.

IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia

2021

Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…

Physical activity and aerobic fitness show different associations with brain processes underlying anticipatory selective visuospatial attention in ad…

2021

ABSTRACTUnderlying brain processes of exercise-related benefits on executive functions and the specific contribution of physical activity vs. aerobic fitness are poorly understood, especially during adolescence. We explored whether and how physical activity and aerobic fitness are associated with selective attention and the oscillatory dynamics induced by an anticipatory spatial cue. Further, we studied whether the link between physical exercise level and cognitive control in adolescents is mediated by the task-related oscillatory activity. Magnetoencephalographic alpha oscillations during a modified Posner’s cueing paradigm were measured in 59 adolescents (37 females and 22 males, 12 to 17…

La gonorrea oggi

2013

Aplicación de la Termografía Infrarroja en Pediatría: Análisis de las alteraciones de la microcirculación cutánea

2020

Desde los inicios de la medicina, se conoce la relación entre enfermedad y las variaciones de temperatura corporal, lo que ha llevado al estudio y desarrollo de técnicas de termometría, que permitiesen cuantificar dichos cambios de temperatura. Entre ellas, destaca la Termografía Infrarroja, que es una técnica de imagen inocua, ya que se basa en captar la emisión de radiación del infrarrojo que emite el cuerpo, es rápida de realizar y accesible, pues se puede realizar cerca del paciente, sin necesidad de desplazamientos ni sedación. Todas estas características hacen que sea una técnica recomendable para utilizar en la población pediátrica que, por su corta edad, es más vulnerable a las radi…

Do opposite ends of same factors underlie life satisfaction vs. depressive symptoms among older people?

2021

Abstract Background Although depressive symptoms are more common among older than younger age groups, life satisfaction tends to remain stable over the life course, possibly because the underlying factors or processes differ. Aim To study whether the factors that increase the likelihood of high life satisfaction also decrease the likelihood of depressive symptoms among older people. Methods The data were a population-based probability sample drawn from community-dwelling people aged 75, 80, and 85 years (n = 1021). Participants’ life satisfaction was measured with the Satisfaction with Life Scale and depressive symptoms with the Centre for Epidemiologic Studies Depression Scale (CES-D). Phy…

MATHEMATICAL MODELLING OF SURFACE ROUGHNESS FOR EVALUATING THE EFFECTS OF WEDM CUTTING PARAMETERS

2020

Wire Electrical Discharge Machining is a cutting method used for obtaining parts with complex geometries or for cutting hard metals. In machining processes, it is necessary to obtain the desired surface quality in order to produce parts providing the required functioning. The surface quality also defines some mechanical properties of the product, such as wear resistance. Being such a considerable quality, surface quality is influenced by various parameters. It will be costly and time consuming to acquire the knowledge of appropriate cutting parameters. Unconventional technologies have not been sufficiently studied so far to provide such details. So, this рарer ѕeekѕ to emрhаѕіze the іmрortа…