Search results for "DAS"
showing 10 items of 4164 documents
A new method for the cytochemical demonstration ofp-diphenol: O2 oxidoreductase (laccase)
1971
Nachweis des Enzymsp-Diphenol: O2 oxidoreductase (Laccase) in den Zellen der PilzeAspergillus fumigatus, Aureobasidium pullulans undNeurospora sitophila durch einen Azofarbstoff, der mittels Kupplung des enzymatisch gebildetenp-Chinons mitBesthorn's Hydrazon(3-Methyl-benzthiazolon(2)-hydrazon-hydrochlorid) entsteht. Als Substrat wird Hydrochinon verwendet. Der Farbstoff wird in runden, rotbraunen Granula abgelagert. Kontrollreaktionen bestatigen die Spezifitat der Reaktion.
A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability.
2006
Fully deprotected phosphonamidate dipeptides, predicted as effective inhibitors of cytosolic leucine aminopeptidase, showed unexpected instability in water solution at pH below 12. Their hydrolysis rate was strictly correlated with basicity of the N-terminal amino group. To improve this feature a phosphonamidate analogue containing less basic, aromatic 2-aminophenylphosphonate residue in P1 position of the inhibitor was designed. The target compound was synthesised starting from diethyl 2-nitrophosphonate in several step procedure. The decrease in basicity of the terminal amino moiety of the modified analogue in fact resulted in satisfactory improvement of hydrolytic stability of the P–N bo…
Antidepressant drugs and memory: Insights from animal studies
2007
This is a selective review of the literature concerning the effects of antidepressant drugs on animal memory, which was performed with the aid of the PubMed database. Monoamine oxidase inhibitors tend to either have no effect on memory or result in its improvement. Studies with cyclic antidepressants have reported no effect or, more often, memory impairments. Pre-training administration of selective serotonin reuptake inhibitors (SSRIs) has been shown to have either no effect on memory or undermine it (with some isolated exceptions, in which improvements have been recorded), while post-training administration of SSRIs has been demonstrated to improve memory or have no effect. A small group …
A Phase III Extension Study of Aldurazyme®(Laronidase) in Mucopolysaccharidosis I
2007
Metabolism of phenol in the terrestrial snail Cepaea nemoralis L
1992
1. The metabolism of phenol in the terrestrial snail Cepaea nemoralis was studied after injection into the haemocoel of the dorsolateral foot region. 2. Excreted metabolites, and metabolites extracted from the body, were analysed by h.p.l.c. In addition to phenyl beta-D-glucoside, arbutine (quinol beta-D-glucoside), a new conjugate of phenol, was detected.
In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation.
2000
The pseudoguaianolide sesquiterpene lactones 4-alpha-O-acetyl-pseudoguaian-6beta-olide (1), hymenin (2), ambrosanolide (3), tetraneurin A (4), parthenin (5), hysterin (6) and confertdiolide (7) were evaluated for their ability to affect the inflammation responses induced by different agents. All the compounds showed activity against the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema. The ethyl phenylpropiolate (EPP)-induced mouse ear edema was inhibited by compounds 3, 5 and 7. However, when sesquiterpene-lactones were assayed on the arachidonic acid (AA)-induced mouse ear edema, none of them were active. The only sesquiterpene lactone orally active against the paw mouse…
The effect of sea water on cytochrome oxidase and oxidative phosphorylation.
1961
Piccole quantita di acqua di mare causano una forte inibizione della fosforilazione ossidativa, mentre l'effetto sulla attivita citocromossidasica e piuttosto modesto. L'ione responsabile di questo effetto e il Calcio.
Two different aggregation principles in reaggregation process of dissociated sponge cells (Geodia cydonium)
1974
Chemisch dissoziierte Zellen des KieselschwammesGeodia cydonium reaggregieren aufgrund zweier verschiedenr Reaggregationsprinzipien. Der Aggnegationsfaktor, auf den die Primaraggregation zuruckgeht, ist membrangebunden und wird durch Proteasen nicht inaktiviert. Der sekundare Aggregationsfaktor wurde 500fach angereichert. Das Molekulargewicht dieses Aggregationsfaktors betragt etwa 20000 Daltons; er ist mit einem ringformigen Makromolekul (2×109 Daltons) assoziiert.
Thermische Denaturierung von Kaltblüter-Enzymproteinen
1960
The temperature, which leads to 50% reduction of catalytic activity by heat denaturation, has been determined for 8 different enzymes from cod muscle, as being in the range between 30 and 52°C. Therefore, there are no indications of a generally different heat resistance of enzymes from cold-blooded animals as compared with those from warm-blooded animals. The same conclusion is derived from calculations ofQ10-values, measured between +37 and − 37°C for cathepsin and glycylglycine dipeptidase.