Search results for "DEFICIENT"
showing 10 items of 75 documents
Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression
2011
International audience; Age-related macular degeneration (AMD) may be partially prevented by dietary habits privileging the consumption of ω3 long chain polyunsaturated fatty acids (ω3s) while lowering linoleic acid (LA) intake. The present study aimed to document whether following these epidemiological guidelines would enrich the neurosensory retina and RPE with ω3s and modulate gene expression in the neurosensory retina. Rat progenitors and pups were fed with diets containing low or high LA, and low or high ω3s. After scotopic single flash and 8-Hz-Flicker electroretinography, rat pups were euthanized at adulthood. The fatty acid profile of the neurosensory retina, RPE, liver, adipose tis…
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.
2006
Alterations in the number and/or morphology of centrosomes are frequently observed in human tumours. However, it is still debated if a direct link between supernumerary centrosomes and tumorigenesis exists and if centrosome amplification could directly cause aneuploidy. Here, we report that hydroxyurea treatment induced centrosome amplification in both human fibroblasts expressing the HPV16 -E6-E7 oncoproteins, which act principally by targeting p53 and pRB, respectively, and in conditional pRB deficient mouse fibroblasts. Following hydroxyurea removal both normal and p53 deficient human fibroblasts arrested. On the contrary pRB deficient fibroblasts entered the cell cycle generating aneupl…
Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice
2011
Mast cell (MC)-deficient c-Kit mutant Kit(W/W-v) mice are protected against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, suggesting a detrimental role for MCs in this disease. To further investigate the role of MCs in EAE, we took advantage of a recently characterized model of MC deficiency, Kit(W-sh/W-sh). Surprisingly, we observed that myelin oligodendrocyte glycoprotein (MOG)(35-55)-induced chronic EAE was exacerbated in Kit(W-sh/W-sh) compared with Kit(+/+) mice. Kit(W-sh/W-sh) mice showed more inflammatory foci in the central nervous system (CNS) and increased T-cell response against myelin. To understand whether the discrepant results obtaine…
Effect of ethanol on yeast film formation
1999
<p style="text-align: justify;">In this study, we have investigated the influence of ethanol on yeast film formation and cell surface hydrophobicity (CSH). A yeast strain (P3) previously isolated from film yeast was grown in a medium containing increasing ethanol concentration ranging from 0 to 14 p. cent (v/v). It results from this study that up to 10 p. cent ethanol, the greater was the ethanol concentration, the greater was the growth of film. Using two different techniques (phase partition method, magnobead assay), we have shown that ethanol altered the CSH of the yeast. The measured hydrophobicity (p. cent) of cells grown without ethanol was 65 p. cent compared with 81 p. cent wi…
Filtering design for two-dimensional Markovian jump systems with state-delays and deficient mode information
2014
This paper is concerned with the problem of H"~ filtering for a class of two-dimensional Markovian jump linear systems described by the Fornasini-Marchesini local state-space model. The systems under consideration are subject to state-delays and deficient mode information in the Markov chain. The description of deficient mode information is comprehensive that simultaneously includes the exactly known, partially unknown and uncertain transition probabilities. By invoking the properties of the transition probability matrix, together with the convexification of uncertain domains, a new H"~ performance analysis criterion for the filtering error system is firstly derived. Then, via some matrix i…
Czerwona lista porostów zagrożonych na Śląsku Opolskim i Górnym Śląsku [Red List of threatened lichens in Opole Silesia and Upper Silesia]
2014
The thirth regional list of threatened and allied fungi is presented. The list is a result of investigation studies in Opole Silesia and Upper Silesia in S Poland. The status of threat to the lichen and allied fungi species used has been determined according to the IUCN Red List Categories in version 3. l (2001). The data obtained were compared with historical ones. While assigning given lichen species to suitable categories of threat the geographic criterium of their occurrence ranges was accepted because most source data from the study area concerns the distribution and frequency of species. The Red List includes 536 taxa of lichens, lichenicolous and saprobic fungi, which constitute 72.9…
Electron-deficient trifluoromethyl-substituted sub-components affect the properties of M4L4 tetrahedral cages
2017
Two supramolecular tetrahedral cages based on a new electron-deficient trifluoromethyl-substituted pyridylimine ligand are synthesised by sub-component self-assembly. Their structures are characterised by NMR und UV-Vis spectroscopy, high-resolution mass spectrometry and single crystal X-ray diffraction. The iron(II) complex shows host–guest chemistry, complex-to-complex transformations and novel electronic properties.
Analysis of attitudes towards disability among university students: a focus on the theory of reasoned action
2011
Los valores democráticos presentes mayoritariamente en occidente han impulsado normas sociales favorables a la inclusión de colectivos en riesgo de exclusión social. Esta investigación se centra en la inclusión de colectivos con discapacidad en el ámbito de la universidad, para lo cual se realizó una encuesta a jóvenes estudiantes universitarios matriculados en la Universidad de A Coruña, en diferentes estudios y niveles, pertenecientes a las ramas de Economía y Empresa. Posteriormente, se llevó a cabo un estudio descriptivo y un análisis factorial basado en la Teoría de la Acción Razonada. Los resultados alcanzados muestran que los valores sociales prevalentes se presentan como la variable…
Luminescence of gamma-radiation-induced defects in alpha-quartz
2004
Optical transitions associated with gamma-radiation-induced defects in crystalline a-quartz were investigated by photoluminescence excited by both pulsed synchrotron radiation and steady-state light. After a 10 MGy gamma-dose we observed two emissions at 4.9 eV (ultraviolet band) and 2.7 eV (blue band) excitable in the range of the induced absorption band at 7.6 eV. These two luminescence bands show a different temperature dependence: the ultraviolet band becomes bright below 80 K; the blue band increases below 180 K, but drops down below 80 K. Both emissions decay in a timescale of a few ns under pulsed excitation, however the blue band could also be observed in slow recombination processe…
Formation of Calcium-Deficient Hydroxyapatite via Hydrolysis of Nano-Sized Pure Α-Tricalcium Phosphate
2015
Nano-sized pure α-tricalcium phosphate (α-TCP) fabricated by a novel synthesis approach shows great potential for a faster transformation into calcium-deficient hydroxyapatite (CDHA) than conventionally prepared α-TCP. In this work, amorphous tricalcium phosphate precursors were precipitated and treated with a solvent (water or ethanol), and dried (freeze-dried and oven-dried) before heating at 775 °C. Nanosized α-TCP powders were investigated for their phase composition and crystallinity, particle shape and size, reactivity and cellular biocompatibility. Reaction with water showed faster CDHA formation for freeze-dried powder, at 6 hours, compared to ethanol treated powders, whereas a high…