Search results for "Dama"

INTEGRATED SYSTEMS IN PLANT PROTECTION MANAGEMENT: FIRE BLIGHT OF ROSACEOUS PLANTS (Erwinia amylovora (Burrill) - Winslow) IN AN APPLE ORCHARD IN SIB…

2013

Integrated protection represents a modern approach, denoting a protection strategy of agro-ecosystems; and it represents a complex system employing all appropriate methods in a manner as consistent and smooth as possible, in order to maintain the biocenotic balance of agrosystems and to keep pathogens at a level at which they do not cause economic damage (so-called level of eco-efficiency). A biocenotic approach to issues of agrosystem protection against disease attack requires an acknowledgement of all aspects regarding the evolution of pests in time and space, so as to be able to intervene at the right time with all possible means. And such protection measures are not supposed to restrain…

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

2011

Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

2012

To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…

Achilles tendon viscoelastic properties and mechanical responses to a single bout of exercise

2014

Quando le garanzie cedono all'ideologia: il diritto penale inquinato dalla legislazione razziale fascista

2021

Furthermore, Fascism produces deep wounds in the development of criminal law. The introduction of the racial corpus becomes a Trojan horse capable of breaching all guarantees. Clear data emerges: the persecution of the Jews takes place primarily outside the parameters of criminal law, but the normatives in defense of the lineage will actually favor racial laws. Mirroring the formal permanence system of liberal guarantees is a stance taken by many criminal lawyers who, in some cases, seem to take a different position than those imposed by the regime, but only in legal journals circulating in the academic field and without any impactful influence on political decisions. There are at least thr…

Intérêts et limites de l’electrostimulation pour l’évaluation, le traitement et la prévention des altérations neuromusculaires induites par l’exercic…

2004

L'objectif de ce travail était d'une part d'étudier les altérations neuromusculaires induites par un exercice excentrique sollicitant les muscles extenseurs du genou, et d'autre part d'étudier l'efficacité de l'électrostimulation (ES) comme moyen d'évaluation, de traitement et de prévention de ces altérations. La première étude de ce travail consistait à évaluer les contributions des mécanismes centraux et périphériques à la diminution de la contraction maximale volontaire observée après l'exercice excentrique. La fatigue basse fréquence (FBF) et la fatigue centrale expliquaient principalement la diminution du moment maximal volontaire après l'exercice excentrique. Le but de la deuxième étu…

Acute and chronic effects of cold treatment on physiological variables and neuromuscular function during a short training period in men

2015

Introduction. Recovery following various physical exercises is a complicated process. The exercise session can involve strong demands on both muscle structure and energy production (aerobic and anaerobic). Many exercise sessions also induce muscle damage (exercise induced muscle damage; EIMD). Different recovery methods attempt to alleviate or prevent EIMD and its associated symptoms, such as muscle soreness and swelling, and reduction in muscle function. One of the used strategies is cold treatment (cryotherapy), which decreases tissue temperature and subsequently effects on e.g. blood flow, metabolism and neural conductance velocity. To date, there is conflicting evidence to support the u…

Monitoraggio e valutazione del danno degli insetti defogliatori su diverse specie di Quercus in Sicilia

Most of the insects feeding on oaks are usually ‘in balance’ with their host trees, causing occasional damage. When severe defoliations regularly occur, oak trees vulnerability to the complex of factors causing the overall decline syndrome can increase. Assessing canopy damage due to defoliating insects through the usually adopted visual methods is quite difficult, requiring highly experienced operators and a long time spent to collect field data. The present research has been carried out to investigate the different susceptibility of Sicilian oak species to defoliating insect attacks, in particular the oak moth Tortrix viridana (L.) (Lepidoptera Tortricidae), with the aim to assess the rel…

Osservazioni intorno a Sopravvenienze e rimedi nei contratti di durata

2019

The essay deals with the subject of contractual change of circumstances and related remedies. In particular, the work focuses on the debate on the possibility of configuring a legal renegotiation obligation in the Italian legal system. The critical examination of favorable positions allows us to offer a more precise reading on the margins of application of the renegotiation.

Analysis of the Effects of Reservoir Operating Scenarios on Downstream Flood Damage Risk Using an Integrated Monte Carlo Modelling Approach

2023

The aim of this study is to analyse the effects of reservoir operating scenarios, for flood damage evaluation downstream of a dam, using a Monte Carlo bivariate modelling chain. The proposed methodology involves a stochastic procedure to calculate flood hydrographs and the evaluation of the consequent flood inundation area by applying a 2D hydraulic model. These results are used to estimate the inundation risk and, as consequence, the relative damage evaluation under different water level conditions in an upstream reservoir. The modelling chain can be summarized as follows: single synthetic stochastic rainfall event generation by using a Monte Carlo procedure through a bivariate copulas ana…