Search results for "Deme"

Dementiaa sairastavien ikääntyneiden elämänlaatu pitkäaikaishoidossa

2011

Tutkimuksen tarkoituksena oli selvittää keskivaikeaa ja vaikeaa dementiaa sairastavien keskisuomalaisten ikääntyneiden elämänlaatua. Elämänlaatua on tutkittu niin maailmalaajuisesti kuin Suomessa paljon, mutta dementiaa sairastavat on otettu tutkimuskohteiksi vasta lähiaikoina. Elämänlaadun kokonaisuus on monipuolinen ja haastava tutkimuskohde, ja sen yhdistäminen dementiaa sairastavien tutkimukseen tuo esiin uusia haasteita. Tutkimus on osa vielä julkaisematonta väitöskirjaprojektia, jossa tutkittiin ikääntyneitä yhdentoista keskisuomalaisen kunnan alueelta. Aineiston keruussa on käytetty Care Keys -projektissa luotuja mittareita, QUALID -elämänlaatumittaria ja Cornell -depressioseulaa. Tu…

Zum Umgang mit Menschen mit Demenz Eine Hinführung

2019

The introduction searches for a guiding principle that can combine personal and institutional care for people with dementia. It approves the point made by Brandenburg & Güther that parts of subjective, objective and hedonistic theories of „good care“ need to be combined in order to identify what makes sense within these approaches. Following Gastmans, human dignity is regarded as the guiding principle for dealing with people with dementia. To do so, it is necessary to (1) see people with dementia as partner in a dialogue; (2) to respect persons for the relationships in which they are embedded; (3) to acknowledge the identity of the person with dementia acquired through his/her history. The …

Music as a mnemonic to learn gesture sequences in normal aging and Alzheimer’s disease

2014

Strong links between music and motor functions suggest that music could represent an interesting aid for motor learning. The present study aims for the first time to test the potential of music to assist in the learning of sequences of gestures in normal and pathological aging. Participants with mild Alzheimer's disease (AD) and healthy older adults (Controls) learned sequences of meaningless gestures that were either accompanied by music or a metronome. We also manipulated the learning procedure such that participants had to imitate the gestures to-be-memorized in synchrony with the experimenter or after the experimenter during encoding. Results show different patterns of performance for t…

2020

Regular physical activity (PA) offers positive effects on the human body. However, the effects of PA on cognition and in the brain are less clear. In this paper, we narratively review the relationship of PA with cognition and dementia, first from general perspective and then through genetically informed studies on the topic. Then we move on to imaging studies on exercise and brain anatomy first by presenting an overall picture of the topic and then discussing brain imaging studies addressing PA and brain structure in twins in more detailed way. Regarding PA and cognition or dementia, genetically informed studies are uncommon, even though the relationship between PA and cognitive ageing has …

Cerebrospinal Fluid Tau Protein Levels and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Differential Diagnosis o…

2010

<i>Aims:</i> In this study, we aimed to compare cerebrospinal fluid (CSF) levels of total tau (t-tau), phosphorylated tau (p-tau<sub>181</sub>) and positron emission tomography with <sup>18</sup>F-fluorodeoxyglucose (FDG-PET) in the differential diagnosis of Alzheimer’s disease (AD) under clinical conditions. <i>Method:</i> In a cross-sectional, blinded, single-center study, we examined a sample of 75 unselected memory clinic patients with clinical diagnoses of dementia of Alzheimer type (DAT; n = 24), amnestic mild cognitive impairment (MCI; n = 16), other dementias (n = 13) and nondemented controls (n = 22). Discriminative accuracy, sensitiv…

Orthostatic hypotension and health outcomes: an umbrella review of observational studies

2019

To investigate potential relationships between orthostatic hypotension (OH) and negative health outcomes and mortality, through an umbrella review with integrated meta-analyses. Orthostatic hypotension is significantly associated with several negative outcomes in older people, but a suggestive evidence is available only for higher risk of coronary heart disease congestive heart failure, stroke, falls dementia, and all-cause mortality. Orthostatic hypotension seems to be significantly associated with several negative health outcomes in older people, even if only associations with coronary heart disease, congestive heart failure, stroke, falls, dementia, and all-cause mortality are supported …

2015

Sir, We read with interest the scientific commentary by Hornberger and Bertoux (2015) on our study on the specificity of prefrontal cortex subregions for strategy use, verbal initiation and suppression (Robinson et al. , 2015). We administered Section 1 and 2 of the Hayling sentence completion task (Burgess and Shallice, 1997) to a large group of frontal and posterior patients. Section 1, assessing verbal initiation, requires the subject to complete sentences with an appropriate word (e.g. ‘ The captain stayed with the sinking …’ could be completed by saying ‘ ship ’). Section 2, assessing inhibition/suppression, requires the completion of sentences with an unconnected word (e.g. ‘ London i…

Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study

2021

Objective: Sensory deficits are important risk factors for delirium but have been investigated in single-center studies and single clinical settings. This multicenter study aims to evaluate the association between hearing and visual impairment or bi-sensory impairment (visual and hearing impairment) and delirium. Design: Cross-sectional study nested in the 2017 "Delirium Day" project. Setting and participants: Patients 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes, and hospices in Italy. Methods: Delirium was assessed with the 4AT (a short tool for delirium assessment) and sensory deficits with a clinical evaluation. …

Long-Term Prognostic Value of Cognitive Impairment on Top of Frailty in Older Adults after Acute Coronary Syndrome

2021

Frailty is a marker of poor prognosis in older adults after acute coronary syndrome. We investigated whether cognitive impairment provides additional prognostic information. The study population consisted of a prospective cohort of 342 older (&gt

Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 …

2020

Background: Alkaline phosphatase has been found on neuronal membranes and plasma alkaline phosphatase (ALP) activity increases during brain injury and cerebrovascular diseases, suggesting that its levels may reflect the neuronal loss. It is known that ALP is higher in subjects affected by Alzheimer’s dementia and inversely correlated with cognitive functions. No study has investigated the relationship between ALP and cognitive functions in old-age subject with pre-clinical cognitive impairment. Methods: This is a cross-sectional study with data gathered from the ReGAl 2.0 project (Rete Geriatrica Alzheimer-Geriatric Network on Alzheimer’s disease), a large Italian multicentric clinical-base…