Search results for "ECL"
showing 10 items of 1262 documents
Blended transdiagnostic group CBT for emotional disorders: A feasibility trial protocol
2021
Introduction Emotional disorders (anxiety and depressive disorders) are a relevant public health concern associated with high prevalence, high costs, and important disability. Therefore, research priorities include designing and testing cost-effective interventions to reach everyone in need. Internet-delivered interventions for emotional disorders are effective and can help to disseminate and implement evidence-based treatments. However, although these treatments are generally effective, not all patients benefit from this treatment format equally. Blended treatments are a new form of intervention that combines the strengths of face-to-face and Internet approaches. Nevertheless, research on …
The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review
2023
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fluctuating weakness of the skeletal muscles. Although antibodies against the neuromuscular junction components are recognized, the MG pathogenesis remains unclear, even if with a well-known multifactorial character. However, the perturbations of human microbiota have been recently suggested to contribute to MG pathogenesis and clinical course. Accordingly, some products derived from commensal flora have been demonstrated to have anti-inflammatory effects, while other have been shown to possess pro-inflammatory properties. In addition, patients with MG when compared with age-matched controls showed a distinctive …
Orígenes y desarrollo de la hagiografía griega a través de la figura de Santa Tecla
2013
En este trabajo examinamos los orígenes y el desarrollo de la hagiografía griega a través de la figura de Santa Tecla. Se trata de un análisis literario diacrónico que comienza en el siglo II con el estudio de los Hechos de Pablo y Tecla y finaliza en el siglo V con la Vida y Milagros de Santa Tecla. Está formado por tres partes fundamentales en las cuales observamos las diferentes etapas en la evolución de la tradición hagiográfica de Tecla a través de los textos griegos que hablan sobre ella. En primer lugar presentamos un análisis literario del texto de los Hechos de Pablo y Tecla poniendo especial atención en su relación con los diferentes géneros literarios de la época (biografía y nov…
Estudio sobre las posibilidades de reclasificación del Sector PRR-4 “Benimaclet” del Plan General de Ordenación Urbana de València, su hipotético cos…
2019
En este “Estudio sobre las posibilidades de reclasificación del Sector PRR-4 del Plan General de Ordenación Urbana de València, su hipotético coste y las medidas de planificación propias de un urbanismo sostenible e integrador para una futura actuación pública sobre ese sector” vamos a tratar de estudiar cuál es el marco jurídico y técnico en que una decisión de desclasificación del sector como urbano (ya sea total o parcial, o ya sea conservando la clasificación pero reduciendo sustancialmente la edificabilidad proyectada) podría intervenir, la legalidad de una determinación de esta índole y, sobre todo, qué costes económicos podría suponer para el Ayuntamiento de València en caso de que h…
Human Rights Against Populism : A Progressive Response to the Politics of Duterte and Mahathir
2018
As the world celebrates the 70th anniversary of the Universal Declaration of Human Rights (UDHR) in 2018–2019, the region of Southeast Asia highlights two compelling political phenomena: the emergent ‘authoritarian populism’ of Rodrigo Duterte in the Philippines and the return to the ‘Asian Values’ of Mahathir Mohamad in Malaysia. nonPeerReviewed
The effect of obesity combined with low muscle strengthon decline in mobility in older persons - Results from the InCHIANTI Study
2009
Objective: Both obesity and muscle impairment are increasingly prevalent among older persons and negatively affect health and physical functioning. However, the combined effect of coexisting obesity and muscle impairment on physical function decline has been little studied. We examined whether obese persons with low muscle strength experience significantly greater declines in walking speed and mobility than persons with only obesity or low muscle strength. Design: Community-dwelling adults aged ⩾65 years (n=930) living in the Chianti geographic area (Tuscany, Italy) were followed for 6 years in the population-based InCHIANTI study. Measurements: On the basis of baseline measurements (1998–2…
Innovative ultrasound systems for preclinical studies: design and production of new instruments and set-ups for in vitro and in vivo experiments – Si…
Patrones de incubación y eclosión del Carbonero Común Parus major en un ambiente mediterráneo: causas y consecuencias
2013
Objetivos generales: Los principales objetivos de esta tesis son describir los patrones de incubación y eclosión de una población de carbonero común Parus major en un ambiente mediterráneo, profundizar en algunas de las causas que afectan a dichos patrones, centrándonos sobre todo en las características del nido, y describir sus posibles consecuencias en el desempeño reproductor. Hipótesis general: Las características parentales, las del nido, y las condiciones ambientales pueden afectar a la duración de los periodos de incubación y eclosión, teniendo consecuencias en el desempeño reproductor. Para poder alcanzar los objetivos generales, hemos identificado varios objetivos particulares, agr…
One pot light assisted green synthesis, storage and antimicrobial activity of dextran stabilized silver nanoparticles.
2014
Background Green synthesis of nanomaterials finds the edge over chemical methods due to its environmental compatibility. Herein, we report green synthesis of silver nanoparticles (Ag NPs) mediated with dextran. Dextran was used as a stabilizer and capping agent to synthesize Ag NPs using silver nitrate (AgNO3) under diffused sunlight conditions. Results UV–vis spectra of as synthesized Ag nanoparticles showed characteristic surface plasmon band in the range from ~405-452 nm. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies showed spherical Ag NPs in the size regime of ~50-70 nm. Face centered cubic lattice of Ag NPs was confirmed by powder X-ray diffraction (PXRD…
PET Imaging of the Impact of Extracellular pH and MAP Kinases on the p-Glycoprotein (Pgp) Activity
2012
The functional activity of p-glycoprotein (Pgp) can be increased in vitro by an extracellular acidosis via activation of MAP kinases (p38, ERK1/2). In order to study these effects in vivo a new (68)Ga-labeled PET tracer was developed which serves as a substrate of the Pgp and therefore indirectly mirrors the Pgp activity. For in vivo studies, experimental tumors were imaged under acidic conditions (inspiratory hypoxia, injection of lactic acid) and during inhibition of MAP kinases in a μ-PET system. In vitro, [(68)Ga]MFL6.MZ showed an accumulation within the cells of about 20% which was increased to 30% by Pgp inhibition. In solid tumors a marked tracer uptake was observed showing spatial h…