Search results for "ERES"
showing 10 items of 2337 documents
Vascular Endothelial Growth Factor-Releasing Microspheres Based on Poly(ε-Caprolactone-PEG-ε-Caprolactone)-b-Poly(L-Lactide) Multiblock Copolymers In…
2020
Pancreatic islet transplantation is a promising advanced therapy that has been used to treat patients suffering from diabetes type 1. Traditionally, pancreatic islets are infused via the portal vein, which is subsequently intended to engraft in the liver. Severe immunosuppressive treatments are necessary, however, to prevent rejection of the transplanted islets. Novel approaches therefore have focused on encapsulation of the islets in biomaterial implants which can protect the islets and offer an organ-like environment. Vascularization of the device’s surface is a prerequisite for the survival and proper func- tioning of transplanted pancreatic islets. We are pursuing a prevascularization s…
THE CARMA INTEREST RATE MODEL
2014
In this paper, we present a multi-factor continuous-time autoregressive moving-average (CARMA) model for the short and forward interest rates. This model is able to present an adequate statistical description of the short and forward rate dynamics. We show that this is a tractable term structure model and provides closed-form solutions to bond prices, yields, bond option prices, and the term structure of forward rate volatility. We demonstrate the capabilities of our model by calibrating it to a panel of spot rates and the empirical volatility of forward rates simultaneously, making the model consistent with both the spot rate dynamics and forward rate volatility structure.
Endoplasmic Reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs
2013
AbstractExit from the Endoplasmic Reticulum (ER) of newly synthesized proteins is mediated by COPII vesicles that bud from the ER at the ER Exit Sites (ERESs). Disruption of ER homeostasis causes accumulation of unfolded and misfolded proteins in the ER. This condition is referred to as ER stress. Previously, we demonstrated that ER stress rapidly impairs the formation of COPII vesicles. Here, we show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER.
Creep Modeling with Time-Dependent Damping Parameters in Piezoelectric Actuators
2019
This paper develops a creep model based on the Kelvin-Voigt model with time varying damping parameters. In the piezoelectric actuators, the creep phenomenon is an important issue in precise positioning applications as well as the hysteresis property. It is well-known that the creep effect can be represented by a series connection of a number of Kelvin-Voigt elements as a viscoelastic model. In the motion for the continuous stepwise positioning, however, the creep shape is different for each response. Since the phenomenon can be captured as temporal creep relaxation, time-dependent damping parameters are introduced to improve the reproducibility of the creep for the various motion. On the ot…
Vida mudéjar en la Marina durante el siglo XV. Una mirada a través de la Bailía General del Reino de Valencia
2009
La vida de las poblaciones mudéjares de la Marina durante el siglo XV fue particularmente activa como manifiestan los registros de Lletres i Privilegis de la Bailía General del reino. Huidas, censales, actividades pesqueras, cambios de domicilio, procesos judiciales, ofrecen imágenes vivas muy concretas de esta realidad que unió a los habitantes mudéjares y cristianos de la zona dentro de sus propias características y formas de vida habituales. (A)