Search results for "ERGO"
showing 10 items of 1165 documents
Human Systems Design: Towards an Integrative Conceptual Framework
2020
International audience; Conceiving artefacts and tools is one of the major key characteristics of the human species. Since the beginning of automation and even more since the spreading of computer science, this activity has become more and more challenging especially through the analysis of the different interaction modes between the artifacts and the human. Nowadays, developing an artifact that must interact with a human is requiring an integrative point of view which must include biological, physical and cybernetical concerns. The current norms aimed at characterizing the quality and the relevance of human machine interface are generally limited to standard interfaces and/or to specific d…
Challenges influencing the safety of migrant workers in the construction industry: A qualitative study in Italy, Spain, and the UK
2021
Abstract The construction industry is notoriously high risk for accidents, injuries, and deaths, particularly for non-national or migrant workers, who comprise a significant proportion of the workforce. This paper presents an international, qualitative study focused on exploring the challenges which influence the safety of migrant construction workers in Italy, Spain, and the UK. Based on a comprehensive review of the literature, we formulated two research questions about the challenges relating to safety that migrant workers face and the challenges to safety training effectively improving migrant workers’ safety behaviours. We present our template analysis of semi-structured interviews and…
A systematic review of human behaviour in and around floodwater
2020
Abstract Flooding can have a major impact on people's safety and livelihood. Understanding people's flood-related behaviours may assist in the development of more effective strategies aimed at lessening the impact of floods including mortality and morbidity. This systematic review examined peer-reviewed literature published from January-1989 to April-2019 on human behaviour in and around floodwater to identify behaviour patterns as well as protective and risk factors. We extracted three main themes from a thematic analysis of included studies (N = 54): activities and risk-taking behaviours (n = 24); loss reduction, knowledge, and warnings (n = 37); and diet and hygiene (n = 4). This review …
New Approaches to Identity in Sport
2020
Welcome to this Special Issue of Journal of Sport Psychology in Action, which offers new theoretical, methodological and applied considerations on what we (the editors) regard as the important topi...
Repurposing of Bromocriptine for Cancer Therapy
2018
Bromocriptine is an ergot alkaloid and dopamine D2 receptor agonist used to treat Parkinson’s disease, acromegaly, hyperprolactinemia, and galactorrhea, and more recently diabetes mellitus. The drug is also active against pituitary hormone-dependent tumors (prolactinomas and growth-hormone producing adenomas). We investigated, whether bromocriptine also inhibits hormone-independent and multidrug-resistant (MDR) tumors. We found that bromocriptine was cytotoxic towards drug-sensitive CCRF-CEM, multidrug-resistant CEM/ADR5000 leukemic cells as well as wild-type or multidrug-resistant ABCB5-transfected HEK293 cell lines, but not sensitive or BCRP-transfected multidrug-resistant MDA-MB-231 brea…
Dysregulated genes and their functional pathways in luteinized granulosa cells from PCOS patients after cabergoline treatment
2018
Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Therefore, to understand the PCOS ovarian physiology, it is important to explore the mechanisms that underlie syndrome based on the therapeutic effects of Cb2. Here, LGCs from non-PCOS and PCOS patients …
A 300 IR sublingual tablet is an effective, safe treatment for house dust mite-induced allergic rhinitis: An international, double-blind, placebo-con…
2021
Background: Allergic rhinitis induced by house dust mites (HDMs) is a highly prevalent but often underdiagnosed and undertreated/untreated chronic disease. It often has a negative impact on sleep, work, leisure activities, and health-related quality of life. Allergen immunotherapy is a proven, safe treatment for respiratory allergies. Objective: We sought to assess the efficacy and safety of a 300 index of reactivity (IR) sublingual tablet formulation of Dermatophagoides pteronyssinus:Dermatophagoides farinae 1:1 extract in adolescents (aged >_12) and adults with moderate to severe HDM-induced allergic rhinitis. Methods: In a phase III, international, double-blind, placebo controlled, rando…
Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes
2017
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Q…
Antioxidant Properties of Ergosterol and Its Role in Yeast Resistance to Oxidation
2021
International audience; Although the functions and structural roles of sterols have been the subject of numerous studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain unclear. It is thought that the specificity of sterols is linked to unidentified supplementary functions that could enable organisms to be better adapted to their environment. Ergosterol is accumulated by late branching fungi that encounter oxidative perturbations in their interfacial habitats. Here, we investigated the antioxidant properties of ergosterol using in vivo, in vitro, and in silico approaches. The results showed that ergosterol is involved in yeast resistance to tert-butyl h…
Species- and site-specific efficacy of commercial biocides and application solvents against lichens
2017
Abstract Control of lichens on stone cultural heritage is mostly achieved by a combination of mechanical removal with biocide applications. However, there is a lack of scientific evidence on the efficacy of different biocides on different species, and on the consistency of biocide effects on heritage sites in different environmental conditions. This results in some uncertainty when conservation interventions to control lichens are routinely defined on the basis of restoration tradition or empirical evaluation, without experimental measures of how lichens respond. In this work, we quantitatively evaluated (a) the efficacy of five commercially-available biocides, applied using a brush or with…