Search results for "FP"

showing 10 items of 297 documents

Wage Cyclicality under Different Regimes of Industrial Relations

2010

Since there is scant evidence on the role of industrial relations in wage cyclicality, this paper analyzes the effect of collective wage contracts and of works councils on real wage growth. Using linked employer-employee data for western Germany, we find that works councils affect wage growth only in combination with collective bargaining. Wage adjustments to positive and negative economic shocks are not always symmetric. Only under sectoral bargaining there is a (nearly symmetric) reaction to rising and falling unemployment. In contrast, wage growth in establishments without collective bargaining adjusts only to falling unemployment and is unaffected by rising unemployment.

Organizational Behavior and Human Resource ManagementLabour economicsReallohnKonjunkturStrategy and Managementmedia_common.quotation_subjectwage cyclicality wage bargaining works council GermanyWageTarifpolitikwage bargainingCollective bargainingManagement of Technology and InnovationEfficiency wageGermanyEconomicsddc:330J31J53Industrial relationsDeutschlandmedia_commonE32Mitbestimmungjel:E32works counciljel:J31jel:J53Arbeitsbeziehungenwage cyclicalityIndustrial relationsUnemploymentWage growthwage cyclicalitywage bargainingworks councilGermanySchätzung
researchProduct

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

2019

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…

PBD Polo box domainMTD maximal tolerance doseCDC25 cell division cycle 25HIF-1α hypoxia-inducible factor 1 αMST microscale thermophoresisIC50 50% inhibition concentrationMFP M phase promoting factorPARP-1 poly(ADP-ribose) polymerase-10302 clinical medicineFOXO forkhead box ONec-1 necrostatin 1CDC2 cell division cycle protein 2 homologGeneral Pharmacology Toxicology and PharmaceuticsMitotic catastropheCDK cyclin-dependent kinase0303 health sciencesChemistryPolo-like kinaseMono-targeted therapyCell cycleBUBR1 budding uninhibited by benzimidazole-related 1Polo box domain030220 oncology & carcinogenesisPLK1 Polo-like kinaseNecroptosisSpindle damagePLK1IHC immunohistochemistryOriginal articleNecroptosisCell cyclePLK1APC/C anaphase-promoting complex/cyclosomePLK3ABC avidin-biotin complexPI propidium iodide03 medical and health sciencesFBS fetal bovine serumPDB Protein Data BankKd the dissociation constantKinase activity030304 developmental biologyAkt/PKB signaling pathwayCell growthlcsh:RM1-950LC3 light chain 3lcsh:Therapeutics. PharmacologyCancer researchDAPKs death-associated protein kinase3-MA 3-methyladenineDAPI 4′6-diamidino-2-phenylindoleSAC spindle assembly checkpointActa Pharmaceutica Sinica B
researchProduct

Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

2020

Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…

PTGS2 Prostaglandin-endoperoxide synthase 2BattleAIV avian influenza virusCoV coronavirusPharmaceutical ScienceiNOS nitric oxide synthaseViral infection0302 clinical medicinePA patchouli alcoholSARS Severe Acute Respiratory SyndromeSMD Sheganmahuang decoctionDrug DiscoveryPandemicIL InterleukinMedicine Chinese TraditionalALI acute lung injuriesmedia_commonCOVID-19 coronavirus disease 2019MXSG Ma xing shi gan decoction0303 health sciencesTNF tumor necrosis factorClinical Trials as TopicCCL2 CC chemokine ligand 2FM1 FM1 coronavirusICU intensive care unitc-AMP cyclic adenosine phosphateHIV human immunodeficiency virus030220 oncology & carcinogenesisCOX-2 cyclooxygenase-2Molecular MedicineHerbal preparationsMedicinal herbsAbbreviations: ACE2 angiotensin-converting enzyme IITCM traditional Chinese medicineHSV-1 herpes simplex virus 1CASP3 caspase 3medicine.medical_specialtyChinaCoronavirus disease 2019 (COVID-19)Systematic surveymedia_common.quotation_subjectJEV Japanese encephalitis virusNF-κB nuclear factor kappa B cellsAntiviral AgentsArticleWHO World Health Organization03 medical and health sciencesIEC-6 rat intestinal epithelial cell line 6SOD superoxide dismutaseCDC Center for Disease Control and PreventionmedicineAVP arginine vasopressinPGE2 prostaglandin E2HumansIntensive care medicineLH Lianhuaqingwen capsule030304 developmental biologyPharmacologyMedicinal herbMDA malondialdehydeGCGJ Gancao ganjiang decoctionNO nitric oxidePlants Medicinalbusiness.industrySARS-CoV-2COVID-19CXCL C-X-C- motif chemokineMDCK Madin-Darby Canine Kidney cellsTLR-4 Toll-like receptor-4COVID-19 Drug TreatmentComplementary and alternative medicineViral infectionLPS lipopolysaccharidesRSV respiratory syncytial virusQFPD Qingfeipaidu decoctionbusinessLung congestionECMO extracorporeal membrane oxygenationMAPK mitogen-activated protein kinasePhytotherapyDrugs Chinese HerbalPhytomedicine : international journal of phytotherapy and phytopharmacology
researchProduct

Simulation and experimental validation of multicarrier PWM techniques for three-phase five-level cascaded H-bridge with FPGA controller

2017

The FPGA represents a valid solution for the design and implementation of control systems for inverters adopted in many fields of power electronics because of its high flexibility of use. This paper presents an overview and an experimental validation of the MC SPWM techniques for a three-phase, five-level, cascaded H-Bridge inverter with FPGA controller-based. Several control algorithms are here implemented by means of the VHDL programming language and the output voltage waveforms obtained from the main PWM techniques are compared in terms of THD%. Simulation and experimental results are analyzed, compared and discussed.

PV systemsGrid connectedSettore ING-IND/31 - ElettrotecnicaFPGA; Grid connected; Multilevel Power Converter; PV systems; VHDLRenewable Energy Sustainability and the EnvironmentEnergy Engineering and Power TechnologyVHDLSettore ING-IND/32 - Convertitori Macchine E Azionamenti ElettriciFPGAMultilevel Power ConverterPV system
researchProduct

Classifier Optimized for Resource-constrained Pervasive Systems and Energy-efficiency

2017

Computational intelligence is often used in smart environment applications in order to determine a user’scontext. Many computational intelligence algorithms are complex and resource-consuming which can beproblematic for implementation devices such as FPGA:s, ASIC:s and low-level microcontrollers. Thesetypes of devices are, however, highly useful in pervasive and mobile computing due to their small size,energy-efficiency and ability to provide fast real-time responses. In this paper, we propose a classi-fier, CORPSE, specifically targeted for implementation in FPGA:s, ASIC:s or low-level microcontrollers.CORPSE has a small memory footprint, is computationally inexpensive, and is suitable for…

Parallel computingMicrocontrollerEnergy-efficientGeneral Computer ScienceComputer scienceDistributed computingComputational intelligenceCellular AutomataClassifierlcsh:QA75.5-76.95EmbeddedAnnan elektroteknik och elektronikEnergy-savingFPGAOther Electrical Engineering Electronic Engineering Information Engineeringbusiness.industryComputer SciencesComputational MathematicsDatavetenskap (datalogi)Embedded systemPervasive systemsSmart environmentlcsh:Electronic computers. Computer sciencebusinessClassifier (UML)Efficient energy use
researchProduct

An Embedded Biometric Sensor for Ubiquitous Authentication

2013

Communication networks and distributed technologies move people towards the era of ubiquitous computing. An ubiquitous environment needs many authentication sensors for users recognition, in order to provide a secure infrastructure for both user access to resources and services and information management. Today the security requirements must ensure secure and trusted user information to protect sensitive data resource access and they could be used for user traceability inside the platform. Conventional authentication systems, based on username and password, are in crisis since they are not able to guarantee a suitable security level for several applications. Biometric authentication systems…

PasswordInformation managementUser informationSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniAuthenticationEngineeringUbiquitous computingBiometricsTraceabilitybusiness.industry FPGA rapid prototypingBiometric identity managementFingerprintSelf-contained sensorUbiquitous authenticationIdentity managementEmbedded systembusinessEmbedded system
researchProduct

Rakstītprasmes apguves veicināšana valdorfskolā 1. klasē

2019

Diplomdarba nosaukums: “Rakstītprasmes apguves veicināšana valdorfskolā 1. klasē”. Darba mērķis: teorētiski pētīt un empīriski pārbaudīt rakstītprasmes apguves veicināšanu valdorfskolā 1. klasē. Darba uzdevumi: 1. apkopot un analizēt teorētisko literatūru par rakstītprasmes veidošanos; 2. apkopot un analizēt teorētisko literatūru un avotus par valdorfpedagoģijas pamatprincipiem un mācību procesu valdorfskolās; 3. apkopot un analizēt teorētisko literatūru par rakstītmācīšanās metodiku valdorfskolās; 4. izstrādāt metodisko materiālu kopu rakstītmācīšanas veicināšanai un veikt ekspertu anketēšanu; 5. analizēt iegūtos rezultātus; 6. izstrādāt secinājumus. Darba apjoms: 48 lappuses, 5 attēli, 5 …

PedagoģijaRūdolfs Šteinersvaldorfpedagoģijarakstītprasmelatviešu valoda
researchProduct

Iekļaujošās izglītības īstenošana Valdorfa bērnudārzā

2019

Diplomdarba mērķis ir izpētīt iekļaujošās izglītības īstenošanu valdorfa pirmsskolas izglītības iestādē. Mērķa sasniegšanai tiek pētīta iekļaujošās izglītības būtība, tās formas un metodes, pētīta Valdorfpedagoģijas būtība un bērna loma tajā. Noslēgumā pētīti iekļaujošās izglītības indikatori un izzināti nosacījumi, lai iekļaujošās izglītības īstenošana Valdorfa bērnudārzā noritētu sekmīgi. Savā diplomdarbā autore apskata iekļaujošās izglītības iespējas tieši Valdorfpedagoģijā, kā tā īstenojas un cik lielas izredzes paveras uz pozitīvu rezultātu. Vai katram bērnam tā der un kas ir jāņem vērā gan pedagogiem, gan vecākiem. Autore apskata iekļaujošās izglītības būtību, kā tā īstenojas bērnudār…

PedagoģijaValdorfpedagoģijaValdorfa bērnudārzsIekļaujošās izglītības indikatoriIekļaujošā pedagoģija
researchProduct

Ritma nozīme pirmsskolas izglītības iestādes pedagoģiskajā procesā: Valdorfpedagoģijas pieeja

2017

Darba tēma. Ritma nozīme pirmsskolas izglītības iestādes pedagoģiskajā procesā: Valdorfpedagoģijas pieeja. Pētījuma mērķis: izanalizēt ritma nozīmi pirmsskolas izglītības iestādē nodarbībās. Atslēgvārdi: Valdorfpedagoģija, ritms, sadarbība, iztēle, radošums, maņas. Pētījuma objekts: Pirmsskolas izglītības iestādes vecākās grupa nodarbības. Pētījuma priekšmets: ritms rotaļnodarbībās . Pirmsskolas vecums ir bērna dzīves periods, kad viņš strauji attīstās visās jomās. Problēma izglītības procesā eksistē tāpēc, ka vecākiem trūkst zināšanu par alternatīvām teorijām. Tikai ciešā sadarbībā ar vecākiem skolotāji varēs veicināt bērna pareizu attīstību. Darbā analizētas R. Šteinera, J. Beļicka, D. Dz…

PedagoģijaValdorfpedagoģijasadarbībaiztēleradošumsritms
researchProduct

A new control system prototype for the energy production maximization of a unequally irradiated PV system

2011

This paper deals with the mismatch effect due to a unequally irradiation on a PV (PhotoVoltaic) system. The mismatch effect due to the partial shading of a PV module can be limited thanks to the installation of both bypass and block diodes. Unfortunately, this solution cannot fully solve the disvantages related to the mismatch effect. The Authors, in previous papers [1, 2], have theoretically demonstrated that the mismatch effect can be solved by changing the parallel/series connections of the modules of a PV system, taking into account each module radiating condition. This paper represents a first step of the experimental development of the above mentioned theoretical result. Specifically,…

PhotoVoltaic mismatch series/parallel connections FPGA controllerSettore ING-IND/32 - Convertitori Macchine E Azionamenti Elettrici
researchProduct