Search results for "G2"
showing 10 items of 439 documents
Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitiv…
2014
Abstract Background Resistance of cancer to chemotherapy remains a challenging issue for scientists as well as physicians. Naturally occurring xanthones possess a variety of biological activities such as anti-inflammatory, anti-bacterial, and anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three naturally occurring xanthones namely, morusignin I (1), 8-hydroxycudraxanthone G (2) and cudraxanthone I (3) against a panel of nine cancer cell lines, including various sensitive and drug-resistant phenotypes. Methods The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was use…
Zvaigžņotā Debess: 2007, Rudens
2007
Latvijas Zinātnes padome, Latvijas Universitāte
Constrained differential inclusions with nonlocal initial conditions
2017
International audience; We show existence for the perturbed sweeping process with nonlocal initial conditions under very general hypotheses. Periodic, anti-periodic, mean value and multipoints conditions are included in this study. We give abstract results for differential inclusions with nonlocal initial conditions through bounding functions and tangential conditions. Some applications to differential complementarity systems and to vector hysteresis are given.
Differential inclusions involving normal cones of nonregular sets in Hilbert spaces
2017
This thesis is dedicated to the study of differential inclusions involving normal cones of nonregular sets in Hilbert spaces. In particular, we are interested in the sweeping process and its variants. The sweeping process is a constrained differential inclusion involving normal cones which appears naturally in several applications such as elastoplasticity, electrical circuits, hysteresis, crowd motion, etc.This work is divided conceptually in three parts: Study of positively alpha-far sets, existence results for differential inclusions involving normal cones and characterizations of Lyapunov pairs for the sweeping process. In the first part (Chapter 2), we investigate the class of positivel…
The London Stock Exchange: Strategic Corporate Governance Restructuring After Demutualization
2014
International audience; This study uses the London Stock Exchange (LSE), forced to demutualize due to major changes in its business environment, notably due to increased competition and technological advances, as field experiment to study corporate governance restructuring to adapt to new market conditions. The LSE improved its financial situation after demutualization and is an example of successful corporate governance restructuring. The LSE significantly restructured the composition of its board of directors following demutualization. The number of exchange members on the LSE board decreased after demutualization while the number of independent directors increased, pointing to a more “mo…
Identification et caractérisation du récepteur à la flagelline (VvFLS2) et recherche du récepteur aux chito-oligosaccharides chez la vigne
2014
Pattern-recognition receptors (PRRs) play a key role in plant immunity by assuring recognition of microbe-associated molecular patterns (MAMPs), signature of microbial presence. MAMP perception constitutes the first layer of pathogen detection and activates defense mechanisms that aim to block the intruder. This study brings an insight into how grapevine (Vitis vinifera) perceives two MAMPs: the flagellin-derived flg22 peptide and chitin, which are conserved motifs occurring over the whole bacterial and fungal classes, respectively. This study analyzed MAMP-triggered early signaling events, defense gene expression and also the efficiency of elicited defense against gray mold and downy milde…
Identification of the VvFLS2 grapevine flagellin receptor by a functional genomics strategy
2013
National audience; Grapevine (Vitis vinifera) is a crop of high agronomic interest subject to many destructive diseases. Pattern recognition receptors (PRRs) mediate detection of potential pathogens via the perception of pathogen associated molecular patterns (PAMPs), which is important for plant disease resistance. A well studied PRR is the Arabidopsis leucine-rich repeat receptor kinase FLS2 that recognizes bacterial flagellin (or its minimal motif flg22). Flagellin perception plays an important role in restricting bacterial invasion into plant leaves. Until now, functional FLS2 orthologues have been characterized in Nicotiana benthamiana, rice and tomato. Despite its economical importanc…
Dacarbazine mediate antimelanoma effects via NK cells.
2013
International audience; Melanoma is a highly chemoresistant and metastatic tumor that, in the absence of BRAF mutations, is generally treated with the alkylating agent dacarbazine (DTIC). We discovered that DTIC upregulates the expression of NKG2D ligands on tumor cells, leading to the activation of natural killer (NK) and CD8(+) T cells. These observations underscore the immunogenic properties of DTIC and provide a rationale to combine DTIC with immunotherapeutic agents.
Dabas vielu lipīdu uzkrāšanās un acetilholīnesterāzes inhibīcija cilvēku aknu šūnu līnijā HepG2 in vitro
2022
Taukaino aknu slimība ir viena no izplatītākajām aknu slimībām attīstītajās valstīs, un tiek iedalīta alkohola un ne-alkohola taukaino aknu slimībā. Taukaino aknu slimībai ir potenciāls progresēt līdz steatohepatītam un cirozei, bet joprojām nav atrastas mērķētas terapijas slimības progresijas palēnināšanai. Maģistra darba mērķis ir pētīt Vaccinium ģints ogu izspaidu ekstraktu iedarbību uz acetilholīna koncentrāciju, acetiholīnesterāzes aktivitāti un lipīdu akumulāciju HepG2 šūnu modelī. Pētījuma rezultāti liecina, ka ogu izspiedu ekstrakti samazina lipīdu akumulāciju šūnās un gan ekstrakti, gan zināmais aknu šūnu funkciju uzlabotājs silimarīns inhibē acetilholīnesterāzes (AChE) aktivitāti.…
Selenofēnkumarīnu un selenofēnhinolonu salīdzinošā ietekme uz HepG2 šūnu fermentatīvo antioksidatīvo sistēmu
2015
Latvijas Organiskās sintēzes institūtā izstrādātas metodes jaunu selenofēn[3,2-c] un [2,3-c]kumarīnu un selenofēn[3,2-c] un [2,3-c]hinolonu sintēzei, kuriem pierādīts antiproliferatīvais efekts in vitro. Darbā tika noteikts savienojumu inhibējošais efekts uz trim hepatomas HepG2 šūnu galvenajiem antioksidatīvajiem fermentiem (GPx, TrxR, SOD) ar mērķi noskaidrot savienojumu antiproliferatīvā efekta darbības mehānismus. Pētījumā konstatēts, ka visi savienojumi ir efektīvi GPx inhibitori. TrxR aktivitāti inhibē selenofēnhinoloni un [3,2-c] aizvietotie selenofēnkumarīni, savukārt SOD aktivitāti ietekmē tikai divi no savienojumiem. Kopumā noteikts, ka selenofēnhinoloni ir aktīvāki antioksidatīvo…