Search results for "G4"

Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer?

2014

Abstract: Immunotherapy has been studied for many years in lung cancer without significant results, making the majority of oncologists quite skeptical about its possible application for non-small cell lung cancer treatment. However, the recent knowledge about immune escape and subsequent cancer immunoediting has yielded the development of new strategies of cancer immunotherapy, heralding a new era of lung cancer treatment. Cancer vaccines, including both whole-cell and peptide vaccines have been tested both in early and advanced stages of non-small cell lung cancer. New immunomodulatory agents, including anti-CTLA4, anti-PD1/PDL1 monoclonal antibodies, have been investigated as monotherapy …

Using protection motivation theory in the design of nudges to improve online security behavior

2019

Abstract We conducted an online experiment (n = 2024) on a representative sample of internet users in Germany, Sweden, Poland, Spain and the UK to explore the effect of notifications on security behaviour. Inspired by protection motivation theory (PMT), a coping message advised participants on how to minimize their exposure to risk and a threat appeal highlighted the potential negative consequences of not doing so. Both increased secure behavior – but the coping message significantly more so. The coping message was also as effective as both messages combined, but not so the threat appeal. Risk attitudes, age and country had a significant effect on behavior. Initiatives seeking to promote se…

Darbinieku adaptācijas procesa pilnveidošana AS “G4S”.

2019

Kvalifikācijas darba tēma ir darbinieku adaptācijas procesa pilnveidošana AS "G4S" Tēmas izvēle prasa sekojošu problēmu analīzi 1. Personāla adaptācijas teorētiskie un metodiskie pamati. Tie tiek pētīti uz fundamentālās ekonomiskās literatūras analīzes pamata. 2. Uzņēmuma un personāla vadības procesa analīze. Uz teorētisko pamatojumu bāzes tiek analizēta AS G4S saimnieciskā darbība, tiek sistematizētas firmas produkta īpatnības un uz šī pamata atvasinātā veidā tiek analizētas AS G4S personāla adaptācijas darbības pamatelementi 3. Personāla adaptācijas procesa uzlabošanas iespējas uzņēmumā. Tiek vispusīgi analizēti esošās personāla adaptācijas procesa elementi un uz pasaules pieredzes pielie…

On the regularity of critical and minimal sets of a free interface problem

2015

We study a free interface problem of finding the optimal energy configuration for mixtures of two conducting materials with an additional perimeter penalization of the interface. We employ the regularity theory of linear elliptic equations to study the possible opening angles of Taylor cones and to give a different proof of a partial regularity result by Fan Hua Lin [Calc Var. Partial Differential Equations, 1993].

Genetic variability among serotype G4 human rotavirus strains circulating in Palermo in the period 1985–2003

2005

AP5Z1/SPG4 8 frequency in autosomal recessive and sporadic spastic paraplegia

2014

Hereditary spastic paraplegias (HSP) constitute a rare and highly heterogeneous group of neurodegenerative disorders, defined clinically by progressive lower limb spasticity and pyramidal weakness. Autosomal recessive HSP as well as sporadic cases present a significant diagnostic challenge. Mutations in AP5Z1, a gene playing a role in intracellular membrane trafficking, have been recently reported to be associated with spastic paraplegia type 48 (SPG48). Our objective was to determine the relative frequency and clinical relevance of AP5Z1 mutations in a large cohort of 127 HSP patients. We applied a targeted next-generation sequencing approach to analyze all coding exons of the AP5Z1 gene. …

Synthesis, characterization and DNA binding studies of potential G4 stabilizer metal complexes

2012

Ni(II) and Zn(II) Schiff Base complexes: B-DNA vs G4-DNA binding

2015

On Pseudofunctors Sending Groups to 2-Groups

2023

For a category B with finite products, we first characterize pseudofunctors from B to Cat whose corresponding opfibration is cartesian monoidal. Among those, we then characterize the ones which extend to pseudofunctors from internal groups to 2-groups. If B is additive, this is the case precisely when the corresponding opfibration has groupoidal fibres.

Interplay of three G‑quadruplex units in the KIT promoter

2019

The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G-rich domain within a relatively long sequence potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1. These G4 domains have been studied mainly as single quadruplex units derived from short truncated sequences and are currently considered promising targets for anticancer drugs, alternatively to the encoded protein. Nevertheless, the information reported so far does not contemplate the interplay between those neighboring G4s in the context of the whole promoter, possibly thwarting dru…