Search results for "HOS"
showing 10 items of 15105 documents
Genome sequence of SeIV-1, a novel virus from the Iflaviridae family infective to Spodoptera exigua
2011
Analysis of the transcriptome of Spodoptera exigua larvae revealed the presence of several ESTs with homology to virus of the order Picornavirales and with the highest similarity to Infectious flacherie virus (Iflaviridae) that infects Bombyx mori larvae. Iflaviridae is a recently defined family of insect-infecting viruses that consist of positive single strand RNA genomes translated into a single polyprotein of around 3000 amino acids long. Using the sequence information derived from the obtained ESTs, we have completed the genomic sequence of this virus. The novel S. exigua iflavirus (SeIV-1) has a genome of 10.3 kb and codes for a 3222 aa polyprotein. Expression analysis has revealed the…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Characterization of the autoantigen La (SS-B) as a dsRNA unwinding enzyme
1997
During the analysis of the La (SS-B) autoantigen for catalytic activities an ATP-dependent double-stranded RNA unwinding activity was detected. Both native and recombinant La proteins from different species displayed this activity, which could be inhibited by monospecific anti-La antibodies. La protein was able to melt dsRNA substrates with either two 3'-overhangs or a single 3'- and a 5'-overhang. Double-stranded RNAs with two 5'-overhangs were not unwound, indicating that at least one 3'-overhang is required for unwinding. Sequence elements of the La protein that might be involved in dsRNA unwinding, such as an evolutionarily conserved putative ATP-binding motif and an element that is hom…
Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)
2008
BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…
Derechos Humanos y democracia en Educación Infantil
2019
Esta aportación muestra una experiencia que gira en torno a los conceptos de Democracia y Derechos Humanos. En este capítulo presentamos propuestas de intervención en el contexto escolar con el fin de explicitar cómo se gestiona un aula democrática basada en el diálogo y la interacción. Pretendemos fomentar un aprendizaje contextualizado y democrático, que se base en el aprender a conocer, a hacer, a vivir juntos y a ser, extendiéndose a lo largo de toda la vida En el aula de Educación Infantil el lenguaje es el motor de la construcción del saber y de las relaciones, por lo que cobra protagonismo en la propuesta pedagógica y en el propio diseño metodológico de la investigación. De este modo…
Electrochemical sensor for phosphate ions based on laser scriber reduced graphene oxide
2022
This preliminary work shows a new and innovative way to produce laser scribed reduced graphene oxide (LSGO) electrodes using different porous substrates (ranging from paper to plastic and fabric). The obtained electrodes were also tested as electrochemical sensors towards the detection of phosphate ions in water. To obtain the electrodes, a water suspension of GO was filtered on top of substrate (such as Whatman® filter paper) and a complete sensor was obtained from its reduction using a CO2 laser. The electrode is composed of working and counter electrodes made of LSGO and a reference electrode of a Ag/AgCl obtained by using a commercial AgCl conductive paste. Phosphate ions were detected …
Characteristics of being hospitalized as a child with a new diagnosis of type 1 diabetes: a phenomenological study of children’s past and present exp…
2015
Background: Our understanding of children and childhood has changed over the last few decades, which may have an impact on children’s conditions in hospitals. Children’s rights have been strengthened by the “Convention on the Rights of the Child” and ward regulations. The aim of this Norwegian study was to identify potential characteristics of children's lived experience of being hospitalized diagnosed with type 1 diabetes today and from a retrospective view in the period 1950–1980, despite the many obvious external changes. Methods: This study presents a further analysis of data from two previous phenomenological studies. The first had a retrospective perspective, and the second assumed a …
Análisis sociojurídico de las transformaciones en la provisión de seguridad. Austeridad y aporofobia como racionalidades estructurantes de los derech…
2021
Desde la perspectiva sociojurídica de los estudios de la gobernabilidad, se analiza la evolución de las estrategias de provisión de seguridad, desde su orientación neoliberal hasta el predominio de la austeridad desde la crisis de 2008. Se delimita así un escenario en el que la desigualdad y la aporofobia son elementos fundamentales del marco axiológico hegemónico. Esto es relevante para la configuración y efectividad de los derechos sociales de distintos grupos vulnerables. El artículo se aproxima finalmente a la situación de las empleadas de hogar y de quienes acceden a una vivienda mediante la ocupación de inmuebles vacíos en España.
Profilo neuropsicologico in pazienti al first episode psychosis e nei familiari di primo grado: un'ipotesi di vulnerabilità genetica
2013
Complex plant quality—microbiota–population interactions modulate the response of a specialist herbivore to the defence of its host plant
2022
Many specialist herbivores have evolved strategies to cope with plant defences, with gut microbiota potentially participating to such adaptations. In this study, we assessed whether the history of plant use (population origin) and microbiota may interact with plant defence adaptation. We tested whether microbiota enhance the performance of Melitaea cinxia larvae on their host plant, Plantago lanceolata and increase their ability to cope the defensive compounds, iridoid glycosides (IGs). The gut microbiota were significantly affected by both larval population origin and host plant IG level. Contrary to our prediction, impoverishing the microbiota with antibiotic treatment did not reduce larv…