Search results for "HUMAN HEALTH"
showing 10 items of 1622 documents
Validation transculturelle des critères d'évaluation rapportés par le patient dans l'arthrose des membres inférieurs
2010
In joint diseases, Patient-Reported Outcomes (PROs) are now critical outcome measures, required by health authorities and regulatory agencies. Cross-cultural adaptation and validation of the psychometric properties of such PROs are needed in order to use them in international therapeutic trials. Thanks to this complex process of cross-cultural validation, the PRO in the target language can take into account the specific socio-cultural features and the linguistic equivalences. The aim of this thesis was to undertake the cross-cultural validation of PROs specifically developed for knee and hip disorders. After explaining the published recommendations for cross-cultural adaptation and then con…
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist – from fundamentals to future challenges
2021
The role of the intestine in human health and disease has historically been neglected and was mostly attributed to digestive and absorptive functions. In the past two decades, however, discoveries related to human nutrition and intestinal host-microbe reciprocal interaction have established the essential role of intestinal health in the pathogenesis of chronic diseases and the overall wellbeing. That transfer of gut microbiota could be a means of disease phenotype transfer has revolutionized our understanding of chronic disease pathogenesis. This narrative review highlights the major concepts related to intestinal microbiota, metabolism, and metabolome (3M) that have facilitated our fundame…
Effects of heat and cold on health, with special reference to Finnish sauna bathing.
2018
Environmental stress such as extremely warm or cold temperature is often considered a challenge to human health and body homeostasis. However, the human body can adapt relatively well to heat and cold environments, and recent studies have also elucidated that particularly heat stress might be even highly beneficial for human health. Consequently, the aim of the present brief review is first to discuss general cardiovascular and other responses to acute heat stress, followed by a review of beneficial effects of Finnish sauna bathing on general and cardiovascular health and mortality as well as dementia and Alzheimer's disease risk. Plausible mechanisms included are improved endothelial and …
Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.
2015
Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.
Plant extracellular vesicles: the safe for bioactive compounds
2021
Abstract If researchers within the field of extracellular vesicles are fascinated by the discovery of what was previously defined as cell rubbish bags and are today considered as important vehicles of biological information, it is even more fascinating to understand that each day, through the diet, we come into contact with vesicles from the plant kingdom, a safe for various compounds with different properties. This chapter will, therefore, focus on the description of studies carried out to date on vesicles originating from the plant kingdom. Above all we will describe the content of the vesicles, looking at the proteomic, lipidomic and nucleic acid composition; we will further discuss the …
Assessment of Bioremediation Strategies for Explosives-Contaminated Sites
2013
Large amounts of soil and water have been contaminated with energetic compounds as a result of the manufacture, storage, testing, use and disposal of munitions as well as the use of nitroaromatic and nitramines as chemical feedstock for synthesis of pesticides, herbicides, dyes, and pharmaceuticals. Historically, TNT (2 methyl-1,3,5, trinitrobenzene) has been the most widely used military explosive (Nicklin et al. 1999; Kulkarni and Chaudhari 2007b). Since TNT is toxic, mutagenic, and also highly energetic (Rosenblatt et al. 1991), TNT contamination has a serious impact on the environment and also threatens human health (Maeda et al. 2007).
Remediation Practice at a Former Missile Base in Latvia
1998
Severe environmental pollution of soil and groundwater exists in Latvia from activities that took place at former Soviet military bases. Since 1994, the former owners of these territories have retaken possession of their lands and have started to use their properties for agriculture, exploitation of forests and recreation. These activities have increased the exposure of populations to toxic substances, with subsequent effects on human health.
An extended reconstruction of human gut microbiota metabolism for personalized nutrition
2020
ABSTRACTUnderstanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex question. However, when applied to nutritional questions, a major issue in existing reconstructions is the lack of information about degradation pathways of relevant nutrients in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of the human gut microbiota metabolism for personalized nutrition. AGREDA includes the degradation pathways of 231 nutrients present in the human diet and…
Why do we need training? - A “Training school on molecular methods used for foodborne parasite diagnostics in different matrices” is a example of kno…
2020
Foodborne parasites with zoonotic potential are of particular concern for human health, being responsible for serious and potentially life threatening diseases. In the last decades, the development of molecular biology techniques have been successfully implemented for clinical diagnosis of FBPs in animal or human samples providing cheaper, less labor intensive, reliable and more sensitive tests. It is apparent from recent publications that unsubstantiated molecular methods for parasite detection that have undergone scant evaluation for sensitivity and specificity are becoming increasingly common. The aim of the organized Training Schools was to transfer knowledge on application, optimizatio…
Why is genetic modification of interest or why can it be useful?
2020
Abstract The genetic modification is a widely debated topic. Pros and cons are substantiated with scientific results or by biased interpretation of experimental results and potential hazards. Genetic modification is a naturally occurring phenomenon. Basic research type of application of genetic modification is teaching us important lessons about the implication of genes in every aspects of life. The applied research–related genetic modifications are offering unprecedented solutions to make plants, animals, and microorganisms bring more benefits, while their impact on environment and human health once they are released into field or get introduced into the food chain needs case-to-case asses…