Search results for "Ham"
showing 10 items of 2612 documents
Controllable Solid Propellant Rocket Motor Stability: Deep and Rapid Variable Thrust Operations
2008
When flow and combustion processes couple with the acoustic modes of the combustion chamber, the solid rocket motors experience unsteady gas motion and associated thrust oscillation and motor vibration. The operations of the variable nozzle introduce relevant dynamic changes in the chamber flow and combustion. This article proposes a non-linear approach for the analysis of the effects of severe nozzle manoeuvres on the controllable solid rocket motor stability and provides the evidence that the acoustic wave amplitude evolution is influenced by the nozzle manoeuvre severity, shape and direction. The additional complexity in the problem of the combustion stability analysis introduced by the …
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines
2015
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinoline skeleton may be exploited as a template for the development of novel anticancer agents. In this article, we report the synthesis and chemical characterization of a new series of isosalsoline-type alkaloids (10-11) with variations at N2 and C3 positions with respect to the natural Compound 2, obtained by a synthetic strategy that involves the Bischler-Napieralski cyclization. The substrate for…
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.
1996
The extracellular domains of a diverse group of membrane proteins are shed in response to protein kinase C activators such as phorbol 12-myristate 13-acetate (PMA). The lack of sequence similarity in the cleavage sites suggests the involvement of many proteases of diverse specificity in this process. However, a mutant Chinese hamster ovary cell line recently isolated for being defective in PMA-activated shedding of the membrane-anchored growth factor transforming growth factor alpha precursor (proTGF-alpha) is concomitantly defective in the shedding of many other unrelated membrane proteins. Here we show that independent mutagenesis and selection experiments yield shedding mutants having th…
The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.
1998
Interleukin-6 (IL-6) belongs to the family of the "four-helix bundle" cytokines. The extracellular parts of their receptors consist of several Ig- and fibronectin type III-like domains. Characteristic of these receptors is a cytokine-binding module consisting of two such fibronectin domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine (WSXWS) sequence motif. On target cells, IL-6 binds to a specific IL-6 receptor (IL-6R), and the complex of IL-6.IL-6R associates with the signal transducing protein gp130. The IL-6R consists of three extracellular domains. The NH2-terminal Ig-like domain is not needed for ligand binding and signal initiation. Here w…
Antilisterial peptides from Spanish dry-cured hams: Purification and identification.
2016
The typical Spanish dry-cured ham has a particular sensory quality that makes it a distinctive food, highly appreciated for consumers worldwide. Its particular physicochemical properties, such as high salt content and reduced water activity contribute to their shelf-stability. However, post-processing actions carried out for the commercialization of these products such as slicing may increase the risk of development of pathogenic microorganisms as Listeria monocytogenes. During ripening, muscle proteins are hydrolyzed by muscle peptidases releasing peptides and free amino acids. Some of these peptides have been described to exert biological activities such as antioxidant and ACE-inhibition.…
Adaptative biochemical pathways and regulatory networks in Klebsiella oxytoca BAS-10 producing a biotechnologically relevant exopolysaccharide during…
2012
Abstract Background A bacterial strain previously isolated from pyrite mine drainage and named BAS-10 was tentatively identified as Klebsiella oxytoca. Unlikely other enterobacteria, BAS-10 is able to grow on Fe(III)-citrate as sole carbon and energy source, yielding acetic acid and CO2 coupled with Fe(III) reduction to Fe(II) and showing unusual physiological characteristics. In fact, under this growth condition, BAS-10 produces an exopolysaccharide (EPS) having a high rhamnose content and metal-binding properties, whose biotechnological applications were proven as very relevant. Results Further phylogenetic analysis, based on 16S rDNA sequence, definitively confirmed that BAS-10 belongs t…
Treatment of patients with spinal muscular atrophy 5q: Towards a new protocol.
2021
Pseudo-Bosons from Landau Levels
2010
We construct examples of pseudo-bosons in two dimensions arising from the Hamiltonian for the Landau levels. We also prove a no-go result showing that non-linear combinations of bosonic creation and annihilation operators cannot give rise to pseudo-bosons.
Two-dimensional Noncommutative Swanson Model and Its Bicoherent States
2019
We introduce an extended version of the Swanson model, defined on a two-dimensional noncommutative space, which can be diagonalized exactly by making use of pseudo-bosonic operators. Its eigenvalues are explicitly computed and the biorthogonal sets of eigenstates of the Hamiltonian and of its adjoint are explicitly constructed.We also show that it is possible to construct two displacement-like operators from which a family of bi-coherent states can be obtained. These states are shown to be eigenstates of the deformed lowering operators, and their projector allows to produce a suitable resolution of the identity in a dense subspace of \(\mathcal{L}^\mathrm{2}\, (\mathbb{R}^\mathrm{2})\).
ChemInform Abstract: An ab initio CI Study on the Rotational Barrier of the Allyl Anion.
1986
All-electron and pseudopotential non-empirical calculations have been performed on C 2v and C s (syn, anti) allyl anion conformations. Using a double-zeta valence-shell basis set within the Epstein-Nesbet definition of the unperturbed Hamiltonian, a value about 19 kcal/mol is found for the barrier to rotation of the allyl anion. This value is the theoretical value obtained with greater accuracy, and the lowest one for the rotational barrier.