Search results for "IAD"
showing 10 items of 711 documents
Physiopathological, Epidemiological, Clinical and Therapeutic Aspects of Exercise-Associated Hyponatremia.
2014
Exercise-associated hyponatremia (EAH) is dilutional hyponatremia, a variant of inappropriate antidiuretic hormone secretion (SIADH), characterized by a plasma concentration of sodium lower than 135 mEq/L. The prevalence of EAH is common in endurance (<6 hours) and ultra-endurance events (>6 hours in duration), in which both athletes and medical providers need to be aware of risk factors, symptom presentation, and management. The development of EAH is a combination of excessive water intake, inadequate suppression of the secretion of the antidiuretic hormone (ADH) (due to non osmotic stimuli), long race duration, and very high or very low ambient temperatures. Additional risk factors …
Antidepressant Effects of Exercise: A Role for the Adiponectin-PGC-1α-kynurenine Triad?
2015
It is well-recognized that exercise improves mental health, e.g., by decreasing depressive behaviors, improving hippocampal-dependent learning and neurogenesis, and increasing dendritic plasticity. Yet how exercise influences the brain at the molecular level is not clearly understood. Yau et al recently reported that the antidepressant effects of physical exercise are mainly mediated by adiponectin, an adipocyte-secreted hormone ('adipocytokine') with neuroprotective effects at the central nervous system level (Yau et al., 2014). 4.155 JCR (2015) Q1, 12/83 Physiology; Q2, 63/187 Cell biology UEM
Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction.
2021
Introduction and objectives: Urinary sodium (UNa+) has emerged as a useful biomarker of poor clinical outcomes in acute heart failure (AHF). Here, we sought to evaluate: a) the usefulness of a single early determination of UNa+ for predicting adverse outcomes in patients with AHF and renal dysfunction, and b) whether the change in UNa+ at 24 hours (Delta UNa24 h) adds any additional prognostic information over baseline values. Methods: This is a post-hoc analysis of a multicenter, open-label, randomized clinical trial (IMPROVE-HF) (ClinicalTrials.gov NCT02643147) that randomized 160 patients with AHF and renal dysfunction on admission to a) the standard diuretic strategy, or b) a carbohydra…
The production of the oral mucosa of antiendomysial and anti-tissue-transglutaminase antibodies in patients with celiac disease: a review.
2010
Celiac disease (CD) is a lifelong, T cell—mediated enteropathy, triggered by the ingestion of gluten and related prolamins in genetically susceptible subjects, resulting in minor intestinal mucosal injury, including villous atrophy with crypt hyperplasia and intraepithelial lymphocytosis, and subsequent nutrient malabsorption. Although serological tests for antiendomysial (EMA) and anti—tissue transglutaminase (anti-tTG) autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is still based on the histological examination of the small intestinal mucosa. Although the small intestinal mucosa is the main site of the gut involved in CD, other mucosal surface…
Lipid triad or atherogenic lipoprotein phenotype: a role in cardiovascular prevention?
2005
The term "lipid triad" or "atherogenic lipoprotein phenotype" has been introduced to describe a common form of dyslipidemia, characterized by three lipid abnormalities: increased plasma triglyceride levels, decreased HDL-cholesterol concentrations and the presence of small, dense LDL particles. It has been suggested that the clinical importance of the atherogenic lipoprotein phenotype probably exceeds that of LDL-cholesterol, because many more patients with coronary artery disease are found to have this trait than hypercholesterolaemia. There is a body of evidence that therapies effective against plasma HDL-cholesterol and triglycerides are associated with a strong reduction of cardiovascul…
The Psychopathy Checklist and non-violent offender groups
1992
Cleckley’s concept of psychopathy includes characteristics such as superficial charm, unreliability, and affective poverty. In this study, the Psychopathy Checklist (PCL) and personality questionnaires (MMPI, CPI, EPQ, and SSS) were used to assess 92 non-violent male offenders. The variable-based approach was applied in order to study the structure of the PCL and the relationships between the PCL, the PCL factors and the personality questionnaire scores. The results indicated that the personality scale scores failed to correlate positively with the PCL score, with the exception of the MMPI hypomania score. Two PCL factors emerged: factor 1 related to the core personality characteristics of …
Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties…
2015
Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.
Pierwszy prezydent. Kształtowanie obrazu Gabriela Narutowicza w pamięci i świadomości historycznej społeczeństwa polskiego. Kilka przykładów z tysiąca
2021
Celem artykułu jest przedstawienie działań podejmowanych na rzecz upamiętnienia postaci Gabriela Narutowicza, pierwszego prezydenta w historii Polski i związanego z tym procesu kształtowania jego wizerunku w pamięci i świadomości historycznej Polaków. Gabriel Narutowicz wybrany na urząd prezydenta w grudniu 1922 r. został zamordowany przez Eligiusza Niewiadomskiego, zaledwie tydzień po elekcji i drugim dniu urzędowania. Śmierć głowy państwa była kulminacją ostrej walki politycznej, która toczyła się na polskiej scenie politycznej w 1922 r. Bezpośrednio po zabójstwie, prezydent G. Narutowicz stał się dla części środowisk politycznych w Drugiej Rzeczypospolitej symboliczną ofiarą polskiego na…
Revista electrónica de investigación y evaluación educativa
2018
La reciente crisis migratoria ha multiplicado el número de personas en edad escolar que migran forzosamente. La integración de los menores en los países de acogida exige no solo su escolarización sino una inclinación de la comunidad educativa para aceptar dicha realidad y gestionar críticamente las políticas europeas migratorias. A nivel europeo hay un creciente rechazo hacia el fenómeno migratorio y hacia las políticas europeas. El estudio analiza las actitudes hacia los refugiados mediante la percepción de amenaza real y simbólica y las reacciones afectivas que los futuros profesores experimentan. Además, explora en qué medida las actitudes hacia los refugiados se relacionan con una ciuda…
Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder
2020
Celiac Disease (CD) is an immune-mediated disease triggered by the ingestion of wheat gliadin and related prolamins from other cereals, such as barley and rye. Immunity against these cereal-derived proteins is mediated by pro-inflammatory cytokines produced by both innate and adaptive system response in individuals unable to adequately digest them. Peptides generated in this condition are absorbed across the gut barrier, which in these patients is characterized by the deregulation of its permeability. Here, we discuss a possible correlation between CD and Autistic Spectrum Disorder (ASD) pathogenesis. ASD can be induced by an excessive and inappropriate brain opioid activity during the neon…